Abstract: The present invention relates to a method for treating or alleviating the symptoms of peripheral arterial disease (PAD) in a subject, comprising administering about 25 mg to about 300 mg of an IL-1? binding antibody or functional fragment thereof.

Abstract: The present invention relates to a method for treating or alleviating the symptoms of peripheral arterial disease (PAD) in a subject, comprising administering about 25 mg to about 300 mg of an IL-1? binding antibody or functional fragment thereof.

Abstract: The present invention relates to a method for treating or alleviating the symptoms of peripheral arterial disease (PAD) in a subject, comprising administering about 25 mg to about 300 mg of an IL-1? binding antibody or functional fragment thereof.

Abstract: Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.

Abstract: Modular laboratory workbenches and work surface accessories are provided. Modular laboratory workbenches may include a spine structure including multiple modules with core passageways for routing utilities. At least one spine structure module may include circuit breakers behind a panel for local electrical power control. The spine structure may include a top with angled faces that provide power outlets, gas terminals, and other utilities. Between angled faces, an accessory support structure may be provided that supports a backsplash in a center channel and provides accessory slots on both sides of the center channel to receive and support interchangeable accessories including monitor arms, tablet arms, gas turrets, supplemental lights, etc. Cantilever brackets of various heights may attach to the spine structure and support work surfaces that are translatable to provide access to the utilities provided on the angled faces of the spine structure.

Abstract: Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.

Abstract: Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.

Abstract: The invention provides methods of diagnosing diseases and conditions associated with PKC?, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in the invention are animal model systems that can be used in screening methods.

Abstract: This invention relates to compositions and methods for use in treating or preventing vascular disease, as well as diseases and conditions associated with hematopoiesis and cellular proliferation.

Abstract: The invention provides methods of diagnosing heart disease, such as heart failure, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the invention are animal model systems that can be used in screening methods.

Abstract: The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.

Abstract: The invention provides methods of diagnosing heart disease, such as heart failure, screening methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. The invention also provides animal model systems for carrying out the screening methods.

Abstract: The invention provides methods of diagnosing heart disease, such as cardiac arrhythmia, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the invention are animal model systems that can be used in screening methods.

Abstract: The invention provides methods of diagnosing heart disease, such as heart failure, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the invention are animal model systems that can be used in screening methods.

Abstract: This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.

Abstract: The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.