Patents by Inventor Mark C. Jenkins

Mark C. Jenkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11000579
    Abstract: Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria maxima, Eimeria tenella, and Eimeria acervulina IMP1 protein in developing active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. Nanoparticle-conjugated rIMP1 immunogenic compositions and methods of making and using them are provided.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: May 11, 2021
    Assignees: The United States of America, as represented by The Secretary of Agriculture, Board of Trustees of Souther Illinois University
    Inventors: Mark C. Jenkins, Vjollca Konjufca
  • Publication number: 20190216911
    Abstract: Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria maxima, Eimeria tenella, and Eimeria acervulina IMP1 protein in developing active immunity to, and control of, coccidiosis. Also provided are methodologies of using the immunogenic compositions for administration to poultry and other animals in the control of coccidiosis. Nanoparticle-conjugated rIMP1 immunogenic compositions and methods of making and using them are provided.
    Type: Application
    Filed: January 11, 2019
    Publication date: July 18, 2019
    Inventors: MARK C. JENKINS, VJOLLCA KONJUFCA
  • Patent number: 8858959
    Abstract: Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: October 14, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Raymond H. Fetterer, Joseph T. Persyn
  • Patent number: 8852596
    Abstract: Immunolocalization of ?- and ?-giardin in Giardia lamblia trophozoites revealed that both giardins are strictly associated with the ventral disc. Optical sectioning of immunolabeled ventral disc, together with quantitative co-localization of ?- and ?-giardin immunoreactivity, demonstrated that ?-giardin is primarily localized to the ventral side, and ?-giardin is localized to the dorsal side of the ventral disc. Antibodies to ?-giardin and ?-giardin can both be used as diagnostic agents; anti-?-giardin antibody can be used as a therapeutic reagent to inhibit binding of trophozoites to host cells.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: October 7, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Ronald Fayer, Monica Santin, Dumitru Macarisin, Celia O'Brien
  • Publication number: 20130017220
    Abstract: Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 17, 2013
    Inventors: Mark C. Jenkins, Raymond H. Fetterer, Joseph T. Persyn
  • Patent number: 7887818
    Abstract: Neospora caninum is the causal agent of bovine neosporosis which results in high levels of abortion. The protective efficacy of two Neospora antigens: Neospora cyclophilin (NcCyP) and NcSRS2 was evaluated. Mice vaccinated with recombinant (r) NcCyP, rNcSRS2, and the combination rNcCyP plus rNcSRS2, formulated with adjuvant ImmuMax-SR® and CpG were challenge-infected 3 weeks following the booster immunization and necropsied 3 weeks after the challenge infection. Mice vaccinated with rNcCyP, rNcSRS2, or the combination of rNcCyP and rNcSRS2 responded with high levels of NcCyP- or NcSRS2- specific antibodies. Mice which received vaccines formulated with either rNcCyP or the combination rNcCyP and rNcSRS2 had a higher (p<0.01) percent protection when compared to the mock- or non-vaccinated mice. Groups immunized with rNcSRS2 alone exhibited slightly lower levels of protection. Results indicate that NcCyP is a highly efficacious vaccine candidate useful in protection against Neospora infection.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: February 15, 2011
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Wenbin Tuo, Mark C. Jenkins, Yan Zhao
  • Publication number: 20090208519
    Abstract: Neospora caninum is the causal agent of bovine neosporosis which results in high levels of abortion. The present study determined the protective efficacy of two Neospora antigens—Neospora cyclophilin (NcCyP) and NcSRS2. The ability of native NcCyP to upregulate mouse IFN? was also confirmed in this study. Recombinant NcCyP or NcSRS2 were tested either alone or in combination and formulated with adjuvant ImmuMax-SR and CpG. Female BALB/c mice (n=15) of 10-12 weeks of age were immunized s.c. twice in a 2-week interval with vaccines containing either NcCyP alone, NcSRS2 alone, NcCyP plus NcSRS2, or non-recombinant bacterial antigen (NR) in 2 separate trials. All mice were challenge-infected 3 weeks following the booster immunization and necropsied 3 weeks after the challenge infection. Brain and serum were collected and Nc-specific DNA sequence in brain tissue and antibodies in serum were analyzed by PCR or ELISA/Western blotting.
    Type: Application
    Filed: February 20, 2008
    Publication date: August 20, 2009
    Inventors: Wenbin Tuo, Mark C. Jenkins, Yan Zhao
  • Patent number: 6710166
    Abstract: Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: March 23, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Ron Fayer, James Trout
  • Patent number: 6521229
    Abstract: Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: February 18, 2003
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Ronald Fayer, James Trout
  • Patent number: 6476192
    Abstract: Antigens for the detection of antibodies to Neospora parasites for the diagnosis of neosporosis have been identified. Recombinant antigens may be produced by expression of DNA sequences derived from Neospora caninum. Both antigens are capable of detecting antibody responses in animals experimentally inoculated with N. caninum but show no evidence of cross-reactivity with serum from animals inoculated with closely related parasites such as Toxoplasma gondii or Sarcocystis species.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: November 5, 2002
    Inventors: Nicola C. Lally, Mark C. Jenkins, Jitender P. Dubey
  • Patent number: 6277973
    Abstract: Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: August 21, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Ron Fayer, James Trout
  • Patent number: 6202249
    Abstract: A floor coating application device with a rigid body having attached thereto a removable applicator and a removable weight system. The rigid body having a planar surface with radial edges to facilitate the uniform application of a coating material to a surface. The removable applicator being a material suitable for uniformly spreading a coating material without flaws or shedding and attached to the rigid body in such a manner as to minimize the wicking of coating material through the applicator. The removable weight system capable of providing a consistent force against the rigid body to improve the uniformity of coating thicknesses. The floor coating application device is used to spread coating material with a handle connected to the rigid body or a mechanical coating device.
    Type: Grant
    Filed: January 7, 1999
    Date of Patent: March 20, 2001
    Assignee: Masterpiece Hardwood Floors
    Inventors: Mark C. Jenkins, Jay M. Jenkins
  • Patent number: 5591434
    Abstract: Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The Proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: January 7, 1997
    Assignees: The United States of America as represented by the Secretary of Agriculture, Kansas State University Research Foundation
    Inventors: Mark C. Jenkins, Ronald Fayer, Michael Tilley, Steven L. Upton
  • Patent number: 5122471
    Abstract: Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences.The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: June 16, 1992
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Hyun S. Lillehoj, John B. Dame, Harry D. Danforth, Michael D. Ruff