Patents by Inventor Mark C. Tsai
Mark C. Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230355429Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: May 12, 2023Publication date: November 9, 2023Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Patent number: 11672696Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: GrantFiled: March 27, 2020Date of Patent: June 13, 2023Assignee: Gyroscope Therapeutics LimitedInventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Patent number: 11337852Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: GrantFiled: February 25, 2019Date of Patent: May 24, 2022Assignee: Gyroscope Therapeutics LimitedInventors: Mark C. Tsai, Brian M. Gatton, Jr., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Patent number: 10806629Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.Type: GrantFiled: May 31, 2017Date of Patent: October 20, 2020Assignee: GYROSCOPE THERAPEUTICS LIMITEDInventors: Daniel W. Price, Brendan J. Oberkircher, James G. Lee, Clinton Denlinger, Daniel J. Prenger, Geoffrey King, Scott Uhland, Mark C. Tsai, Michael F. Keane, Isaac J. Khan, Benjamin L. Ko, Thomas E. Meyer, Denis P. Turner
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Patent number: 10806630Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.Type: GrantFiled: April 29, 2020Date of Patent: October 20, 2020Assignee: GYROSCOPE THERAPEUTICS LIMITEDInventors: Daniel W. Price, Brendan J. Oberkircher, James G. Lee, Clinton Denlinger, Daniel J. Prenger, Geoffrey King, Scott Uhland, Mark C. Tsai, Michael F. Keane, Isaac J. Khan, Benjamin L. Ko, Thomas E. Meyer, Denis P. Turner
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Publication number: 20200297531Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.Type: ApplicationFiled: April 29, 2020Publication date: September 24, 2020Inventors: Daniel W. Price, Brendan J. Oberkircher, James G. Lee, Clinton Denlinger, Daniel J. Prenger, Geoffrey King, Scott Uhland, Mark C. Tsai, Michael F. Keane, Isaac J. Khan, Benjamin L. Ko, Thomas E. Meyer, Denis P. Turner
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Publication number: 20200222232Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: March 27, 2020Publication date: July 16, 2020Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Patent number: 10639193Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: GrantFiled: March 19, 2018Date of Patent: May 5, 2020Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Publication number: 20190183674Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: ApplicationFiled: February 25, 2019Publication date: June 20, 2019Inventors: Mark C. Tsai, Brian M. Gatton, JR., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Patent number: 10258502Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: GrantFiled: September 2, 2015Date of Patent: April 16, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Mark C. Tsai, Brian M. Gatton, Jr., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Publication number: 20180289540Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: March 19, 2018Publication date: October 11, 2018Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Patent number: 9949874Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: GrantFiled: June 1, 2015Date of Patent: April 24, 2018Assignee: Janssen Biotech, Inc.Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Publication number: 20170360606Abstract: An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.Type: ApplicationFiled: May 31, 2017Publication date: December 21, 2017Inventors: Daniel W. Price, Brendan J. Oberkircher, James G. Lee, Clinton Denlinger, Daniel J. Prenger, Geoffrey King, Scott Uhland, Mark C. Tsai, Michael F. Keane, Isaac J. Khan, Benjamin L. Ko, Thomas E. Meyer, Denis P. Turner
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Publication number: 20160081849Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.Type: ApplicationFiled: September 2, 2015Publication date: March 24, 2016Inventors: Mark C. Tsai, Brian M. Gatton, JR., Michael F. Keane, Isaac J. Khan, Brendan J. Oberkircher, Daniel W. Price
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Publication number: 20150351958Abstract: An apparatus has a first fluid conduit, a second fluid conduit, a connector member, an first tubular member, a second tubular member, and an inner cannula. The connector member has first and second passageways in which the first and second fluid conduits are positioned, respectively. A portion of the second tubular member is positioned within the lumen of the first tubular member. A proximal portion of the inner cannula is fixedly secured within the lumen of the first tubular member. The inner cannula lumen is in fluid communication with the first and second fluid conduits via the lumen of the first tubular member and the lumen of the second tubular member. The inner cannula may be inserted into the subretinal space of a human eye to deliver a leading bleb of fluid and then deliver a therapeutic agent, without having to withdraw the inner cannula from the subretinal space between the acts of delivering the leading bleb delivering the therapeutic agent.Type: ApplicationFiled: June 1, 2015Publication date: December 10, 2015Inventors: Joseph H. Contiliano, Thomas E. Meyer, Daniel J. Abbott, Michael F. Keane, Allen C. Ho, Mark C. Tsai, Isaac J. Khan
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Patent number: 7601140Abstract: A relatively stiff syringe pressure applicator having a pair of ears, the ears are overmolded with a relatively soft elastomer. A port extends through the syringe pressure applicator and is connected to friction fittings on either side of the pressure applicator. The external fitting is suitable for connecting to a source of pressurized air. The other fitting is sized and shaped to receive an elastomeric seal that may be inserted into the open end of a syringe to seal the syringe air tight.Type: GrantFiled: June 25, 2004Date of Patent: October 13, 2009Assignee: Alcon, Inc.Inventors: Richard A. Rossback, Mark C. Tsai