Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.

Abstract: Various methods, apparatuses/systems, and media for implementing a release automation dashboard module are disclosed. A database that stores a set of Sarbanes-Oxley (SOX) audit rules. A processor is coupled to the database via a communication network. The processor creates a release; checks the release for violations against the set of Sarbanes-Oxley (SOX) audit rules; validates that the release is scanned for cyber vulnerabilities in accordance with an organization's established practices; and authorizes deployment of the release based on a determination that the one or more features from the release does not violate the set of SOX audit rules and that the one or more features from the release meet a predetermined threshold for the cyber vulnerabilities.

Abstract: Methods, systems, and computer program products are included for performing a transaction, where log entries pertaining to the transaction are maintained following the transaction for audit purposes. The log entries may include information about the transaction at various stages, including time information, information regarding operations performed, state information and originator information.

Abstract: A method for performing asynchronous communication includes executing a thread, by a computing system, the thread comprising an instruction to send a message to a remote system under a current set of conditions. The method further includes waiting, by the computing system for a response to the message for a predetermined amount of time, wherein the predetermined amount of time is calculated based on historical data, wherein the historical data comprises one or more response times for respective one or more messages, wherein the one or more messages are associated with a set of conditions that correspond to the current set of conditions.

Abstract: Various methods, apparatuses/systems, and media for implementing a release automation dashboard module are disclosed. A database that stores a set of Sarbanes-Oxley (SOX) audit rules. A processor is coupled to the database via a communication network. The processor creates a release; checks the release for violations against the set of Sarbanes-Oxley (SOX) audit rules; validates that the release is scanned for cyber vulnerabilities in accordance with an organization's established practices; and authorizes deployment of the release based on a determination that the one or more features from the release does not violate the set of SOX audit rules and that the one or more features from the release meet a predetermined threshold for the cyber vulnerabilities.

Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.

Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.

Abstract: Systems and methods for disabling applications on a client device remotely are disclosed. An example method may comprise establishing, via a network interface device, a communication connection with a client computing device, receiving, via the communication connection, a list of applications installed on the client computing device, comparing the received list of applications to a blacklist of applications, identifying, in view of the comparing, an installed application on the received list of applications, the installed application comprised in the blacklist of applications, identifying a severity score corresponding to the installed application and an action corresponding to the severity score, and responsive to the identifying the severity score and the corresponding action, causing, by the processing device, the corresponding action to be performed with respect to the client computing device, the corresponding action pertaining to the installed application.

Abstract: A method includes receiving, by a mobile device associated with a distributed transaction, a message via a messaging service provided by a mobile network operator. The method further includes determining, by a content based router of the mobile device, that the message is associated with the distributed transaction by determining that the message includes a transaction identifier that corresponds with an entry in a transaction table of the content based router. The entry identifies the distributed transaction and a destination of where to forward the message. The method further includes forwarding, by a processing device of the mobile device, the message to a resource manager resident on the mobile device. The resource manager corresponds to the destination of where to forward the message. The method further includes performing, by the resource manager, an action associated with the distributed transaction in view of contents of the message.

Abstract: Compositions including a therapeutically effective amount of an HIV immunogen in combination with an agent that stimulates the Ras pathway, wherein the agent is not an aluminum salt, are disclosed. Methods are also disclosed for inducing an immune response to HIV, and/or to inhibit or treat HIV infection, in a subject, using an HIV immunogen and an agent that stimulates the Ras pathway. Methods also are disclosed for determining if an immunogenic composition will induce a protective response, and/or to determine if an immunogenic composition is of use to prevent or treat an HIV infection. The methods including determining if the immunogenic composition increases the level of one or more components of the Ras signaling pathway.

Abstract: A method for performing asynchronous communication includes executing a thread, by a computing system, the thread comprising an instruction to send a message to a remote system under a current set of conditions. The method further includes waiting, by the computing system for a response to the message for a predetermined amount of time, wherein the predetermined amount of time is calculated based on historical data, wherein the historical data comprises one or more response times for respective one or more messages, wherein the one or more messages are associated with a set of conditions that correspond to the current set of conditions.

Abstract: A method performed by a computing system includes, executing a thread, the thread comprising an instruction to send a message to a remote system, after sending the message, allowing continued execution of the thread, after a first period of time, checking for a response to the message, and in response to determining that the response has not been received and that the first period of time is less than a predetermined amount of time, waiting for an additional period of time for the response. The predetermined amount of time is based on collected data associated with a set of conditions that correspond to a current set of conditions related to the remote system.

Abstract: Systems and methods for disabling applications on a client device remotely are disclosed. An example method may comprise establishing, via a network interface device, a communication connection with a client computing device, receiving, via the communication connection, a list of applications installed on the client computing device, comparing the received list of applications to a blacklist of applications, identifying, in view of the comparing, an installed application on the received list of applications, the installed application comprised in the blacklist of applications, identifying a severity score corresponding to the installed application and an action corresponding to the severity score, and responsive to the identifying the severity score and the corresponding action, causing, by the processing device, the corresponding action to be performed with respect to the client computing device, the corresponding action pertaining to the installed application.

Abstract: A status inquiry message is received at a first machine, wherein the status inquiry message is a network protocol layer request. A status response message is generated at the first machine, the status response message responsive to the network protocol layer request. Management information is attached to the status response message, the management information including application layer information about one or more of the first machine and a service operating on the first machine. The status response message is transmitted to the second machine.

Abstract: A method and apparatus for dispatching messages in a distributed computing system. A dispatcher receives a message. The dispatcher examines the message to determine whether the message is addressed to the dispatcher. If the message is addressed to the dispatcher, the dispatcher performs an action based on the message. If the message is not addressed to the dispatcher, the dispatcher passes on the message to a destination.

Abstract: During a distributed transaction, a computing device that hosts a participant of the distributed transaction intercepts an operation to change a resource from an initial state to a resultant state. The computing device determines an inverse operation that will change the resource from the resultant state back to the initial state. The computing device records the inverse operation and performs the operation.

Abstract: A system for animal weight management relates to the technical field of optimising animal weight and therefore health. It can be a problem that domestic animals may become underweight or overweight and it can be difficult to obtain accurate information relating to diet and exercise and so difficult to effectively treat animals. The system comprises a database having animal food information, a food plan section to allow creation of a food plan for an animal, an exercise plan section to allow creation of an exercise plan for the animal, a monitoring section including storage to store information about the weight history of the animal and the animal's activity, and a monitor adapted to be attached to the animal and provide information about the animal's activity to the monitoring section. The system is principally used by animal health professionals and animal caregivers on domestic animals to optimise the weight and therefore health of the animals.

Abstract: A read-only message is sent by a first participant of multiple participants of a two-phase distributed transaction. The read-only message is received by a processor executing a coordinator node. A one-phase distributed transaction is initiated for a second participant of the multiple participants that did not respond with a read-only message.

Abstract: A status inquiry message is generated at a first machine, wherein the status inquiry message is directed to one of a second machine or a service operating on the second machine. A status inquiry message is transmitted to the second machine. The first machine receives a status response message; the status response message indicating management information from the second machine.

Abstract: A spice mill includes a gear mechanism operable in a first operational state wherein the gear mechanism is coupled to a first grinding mechanism and a second operational state wherein the gear mechanism is coupled to a second grinding mechanism. A selector connected to the gear mechanism is movable between a first position and a second position. In the first position the gear mechanism is operable in the first operational state and in the second position the gear mechanism is operable in the second operational state. A cover part is rotatably mounted to the body and connected to the gear mechanism. Rotation of the cover part in a first direction rotates the first grinding mechanism when the gear mechanism is in the first operational state and rotation of the cover part in the first direction rotates the second grinding mechanism when the gear mechanism is in the second operational state.