Abstract: Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: A message is received by a mobile phone via a messaging service provided by a mobile network operator, wherein the messaging service is supported by the mobile phone. It is determined whether the message is associated with a distributed transaction. The message is forwarded to a resource manager resident on the mobile phone if the message is associated with the distributed transaction. The resource manager performs an action upon receiving the message based on contents of the message, wherein the action is associated with the distributed transaction.

Abstract: A message is received at a message consumer, the received message having a component dependency identification that indicates a version of a software component that is necessary to process the message. The version of the software component is automatically downloaded if the message consumer does not already include the version of the software component. The version of the software component is then used to process the received message.

Abstract: A status inquiry message is received at a first machine via a network, wherein the status inquiry message is directed to one of the first machine or a service operating on the first machine. A status response message is generated at the first machine, the status response message indicating that at least one of the first machine or the service is operational. Management information is attached to the status response message, the management information including operating statistics of at least one of the first machine, the service, or an additional service that operates on the first machine. The status response message is transmitted to the second machine.

Abstract: A commit query is sent from a coordinator of a two-phase commit distributed transaction to each participant of the distributed transaction, wherein each participant can respond with one of a commit message, an abort message, or a read-only message. A read-only message is received from all but one participant of the distributed transaction. A one-phase commit distributed transaction is initiated for the one participant that did not respond with a read-only message.

Abstract: A message addressed to an application operating on a destination machine is received at an intermediate machine. Management information is attached to the message, the management information including operating statistics of the intermediate machine. The message is forwarded to the destination machine.

Abstract: A dependency is identified between a first component of a distributed computing system and a second component of the distributed computing system if the first component invokes the second component. A dependency map of the distributed computing system that includes the dependency between the first component and the second component is built.

Abstract: A message that includes an end user license agreement is received at a client from a service in a distributed computing system. The client determines whether to accept the end user license agreement. The message is processed if the end user license agreement is accepted.

Abstract: A message directed to a first version of a service is received at a content based router in a distributed computing system. The message is transmitted to a second version of the service instead of the first version of the service if the message is compatible with the second version of the service. The message is transmitted to the first version of the service if the message is not compatible with the second version of the service.

Abstract: The invention is directed to a compound of the structural formula (22) (22) crystal form of structural formulae (21) and its free acid, pharmaceutical compositions comprising these compounds and methods of preparing and using these compounds.

Abstract: A message sent to a first service addressed in a distributed computing environment having a service oriented architecture is received, wherein the message is directed to a service that is no longer present at the first service address. The message is forwarded to a second service address at which the service is located.

Abstract: Data is divided into a plurality of blocks. A unique identifier is assigned to each of the plurality of blocks. A key is generated that identifies how to reconstruct the data from the plurality of blocks. The key and each of the plurality of blocks are transmitted to a recipient.

Abstract: A service policy is modified for a service in a distributed computing environment having a service oriented architecture. A client is notified of the modified service policy without use of a service registry.

Abstract: Methods and apparatus for providing a switch that includes multiple parts, and is arranged to function after extended periods of being in a depressed state are disclosed. In one embodiment, a multi-part switch includes a first contact, a second contact, and a plate. The first contact is electrically coupled to a first lead on a circuit board, and a second contact is electrically coupled to a second lead on the circuit board. The plate includes an electrically conductive area that contacts the first contact and the second contact to allow a signal to flow from the first contact to the second contact through the plate. In contacting the first contact and the second contact, the plate applies a compressive force to the first contact and to the second contact.

Abstract: A method and apparatus for recreating a system state in a non-deterministic distributed computing system. A message generated by a message producer is received during debugging. If the received message matches a stored message in a persistent message store, the received message is transmitted to a message consumer. If the received message does not match the stored message, the stored message is transmitted to the message consumer.

Abstract: A method and apparatus for using a persistent message store in a distributed computing system having a service oriented architecture. A message is detected that is transmitted from a message producer to a message consumer in the distributed computing system having the service oriented architecture. A determination is made as to whether the message should be copied based on at least one predetermined criterion. A copy of the message is generated if the message is to be copied. The copy of the message is stored in the persistent message store.

Abstract: A method and apparatus for using rules in a distributed computing system. A message is generated. One or more rules are associated with the message, each of the one or more rules pertaining to an action to be performed. The message is sent to a destination with the associated rules.

Abstract: A method and apparatus for using a persistent message store in a distributed computing system. A message is stored in a persistent message store, wherein the message is a copy of an original message transmitted from a message producer to a message consumer in a distributed computing system. A command is received from a requestor to search the persistent message store for a stored message, the command indicating a search rule. The search rule is processed by a rules engine of the persistent message store to search for the stored message.

Abstract: A method and apparatus for dispatching messages in a distributed computing system. A dispatcher receives a message. The dispatcher examines the message to determine whether the message is addressed to the dispatcher. If the message is addressed to the dispatcher, the dispatcher performs an action based on the message. If the message is not addressed to the dispatcher, the dispatcher passes on the message to a destination.

Abstract: Methods and apparatus for providing a switch that includes multiple parts, and is arranged to function after extended periods of being in a depressed state are disclosed. In one embodiment, a multi-part switch includes a first contact, a second contact, and a plate. The first contact is electrically coupled to a first lead on a circuit board, and a second contact is electrically coupled to a second lead on the circuit board. The plate includes an electrically conductive area that contacts the first contact and the second contact to allow a signal to flow from the first contact to the second contact through the plate. In contacting the first contact and the second contact, the plate applies a compressive force to the first contact and to the second contact.