Abstract: A fluid management system for use with an ultrasound probe assembly can include first and second conduits each configured to extend from and be fluidly connected to the ultrasound probe assembly. A fluid directing system can include a circulation pump fluidly connected to both the first and second conduits. A fluid degassing system can be fluidly connected to the first and second conduits. The fluid degassing system can be configured to remove at least some gas from the fluid in the ultrasound probe assembly. A temperature control system can be fluidly connected to the first and second conduits. The temperature control system can be configured to control the temperature of the fluid in the ultrasound probe assembly. A volume adjustment system can be fluidly connected to the first and second conduits. The volume adjustment system can be configured to adjust the volume of the fluid in the ultrasound probe assembly.

Abstract: A method of treating colorectal cancer included placing a high intensity focused ultrasound (HIFU) probe proximate a designated treatment volume at one of the colon and the rectum of a patient. The method further includes delivering HIFU via the HIFU probe at a frequency of at least 1 mHz for at least 3 seconds to raise a temperature of a first portion of the designated treatment volume to above 65° C., thereby ablating the first portion and causing a tissue defect within the designated treatment volume. The method further includes applying a nonablative dose of energy via the HIFU probe to a second portion of the designated treatment volume to provoke stem cell homing in the second portion, thereby encouraging tissue regrowth.

Abstract: There is presented a removable high-intensity focused ultrasound (HIFU) transducer and supporting system that allows for HIFU transducer assemblies and other therapeutic ultrasound assemblies to be attached to third party positioning, imaging, or guidance systems while maintaining the required focal-zone positioning ability and the required acoustic energy coupling to tissue, to mechanically or automatically ablate a target volume in unimpeded fashion. There is provided an acoustically transparent and pliable vessel that has an open top end and filled with acoustic coupling fluid, capable of holding the transducer assembly and distal end of the positioning system within it as it executes the HIFU treatment plan/process. The vessel is held in place using a transducer/positioning system and independent external fixturing mechanism.

Abstract: A method of treating colorectal cancer included placing a high intensity focused ultrasound (HIFU) probe proximate a designated treatment volume at one of the colon and the rectum of a patient. The method further includes delivering HIFU via the HIFU probe at a frequency of at least 1 mHz for at least 3 seconds to raise a temperature of a first portion of the designated treatment volume to above 65° C., thereby ablating the first portion and causing a tissue defect within the designated treatment volume. The method further includes applying a nonablative dose of energy via the HIFU probe to a second portion of the designated treatment volume to provoke stem cell homing in the second portion, thereby encouraging tissue regrowth.

Abstract: A method for delivering ultrasound can include positioning at least a focal zone of a transducer of an ultrasound probe proximate to targeted tissue of a patient. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to a first portion of the targeted tissue for a predetermined amount of time to create a first focal lesion in the targeted tissue. The method can include at least temporarily ceasing power to the transducer so as to at least temporarily cease delivery of ultrasound energy from the transducer to the targeted tissue. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to the targeted tissue at least substantially continuously and along a predefined treatment path.

Abstract: A probe tip assembly for receiving at least a portion of an ultrasound probe therein includes a body having a proximal end and an opposing distal end. A first opening may be located at the proximal end of the body. The first opening may be sized and shaped to receive at least a portion of the probe therein. A second opening may be proximate the distal end of the body. A membrane may cover the second opening.

Abstract: An apparatus for and a method of performing sonasurgery may include a room coordinate system and at least one probe with localization technology. A position of the probe may be tracked continuously during the course of a procedure so that its position is known and updated relative to a preoperative MRI/CT.

Abstract: A device including a focused ultrasound probe, a first balloon, and a second balloon. The first balloon can be located at least partially inside the second balloon. The inner balloon can be configured to act as a fluid interface, a mechanism for cooling, and a mechanism for changing tissue depth of a focal point of the probe. The second balloon can be filed with a thermosensitive hydrogel configured to turn from a fluid at room temperature to a gel at physiologic temperatures. The first and second balloons can be configured to create a fluid interface between the probe and targeted tissue of a patient.

Abstract: A system for providing focused ultrasound may include a focused ultrasound probe including at least one transducer. At least one variable volume fluid bladder may be positioned between at least a portion of the transducer and tissue to be treated. The system may further include a reservoir containing fluid and a first pump operatively connected to the bladder and the reservoir. The first pump may be configured to move fluid into the bladder. A second pump may be operatively connected to the bladder and the reservoir. The second pump may be configured to move fluid out of the bladder.

Abstract: A fluid management system for use with an ultrasound probe assembly can include first and second conduits each configured to extend from and be fluidly connected to the ultrasound probe assembly. A fluid directing system can include a circulation pump fluidly connected to both the first and second conduits. A fluid degassing system can be fluidly connected to the first and second conduits. The fluid degassing system can be configured to remove at least some gas from the fluid in the ultrasound probe assembly. A temperature control system can be fluidly connected to the first and second conduits. The temperature control system can be configured to control the temperature of the fluid in the ultrasound probe assembly. A volume adjustment system can be fluidly connected to the first and second conduits. The volume adjustment system can be configured to adjust the volume of the fluid in the ultrasound probe assembly.

Abstract: An ultrasound delivery system can include a console assembly having a display and a computer system, and a positioning assembly operatively connected to the console assembly. The positioning assembly can be articulable between a plurality of different configurations upon receipt of one or more instructions from the computer system. The positioning assembly can include at least one gripper mechanism configured to selective grip and release. At least one probe assembly can include an ultrasound transducer assembly, a first bolus assembly and a second bolus assembly. The first bolus assembly can have at least a different geometry than the second bolus assembly. At least a portion of the ultrasound transducer assembly can be removably positionable within each of the first bolus assembly and the second bolus assembly. At least a portion of the probe assembly can be selectively connected to gripper mechanism and moved by the positioning assembly.

Abstract: A device including a focused ultrasound probe, a first balloon, and a second balloon. The first balloon can be located at least partially inside the second balloon. The inner balloon can be configured to act as a fluid interface, a mechanism for cooling, and a mechanism for changing tissue depth of a focal point of the probe. The second balloon can be filed with a thermosensitive hydrogel configured to turn from a fluid at room temperature to a gel at physiologic temperatures. The first and second balloons can be configured to create a fluid interface between the probe and targeted tissue of a patient.

Abstract: A method for delivering ultrasound can include positioning at least a focal zone of a transducer of an ultrasound probe proximate to targeted tissue of a patient. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to a first portion of the targeted tissue for a predetermined amount of time to create a first focal lesion in the targeted tissue. The method can include at least temporarily ceasing power to the transducer so as to at least temporarily cease delivery of ultrasound energy from the transducer to the targeted tissue. The method can include supplying power to the transducer to deliver ultrasound energy from the transducer to the targeted tissue at least substantially continuously and along a predefined treatment path.

Abstract: A method for delivering therapeutic ultrasound to a patient to ensure full treatment of targeted tissue can include performing preoperative imaging of a first volume of targeted tissue of a patient using an ultrasound probe and creating a first treatment plan. Energy can be delivered into at least a distal portion of the first volume. The amount of energy delivered can be sufficient to produce swelling of tissue in the first volume. The first volume can be reimaged to identify if any changes have occurred in at least one of a size, shape and location of the first volume of the targeted tissue. A second treatment plan can be designed to treat a second volume of tissue equivalent to the changed first volume of targeted tissue. Energy can be delivered into the second volume of the targeted tissue.

Abstract: A method can include placing a high intensity focused ultrasound probe proximate a designated treatment volume of a patient, ablating a first portion of the designated treatment volume with the probe using at least one pulse sequence and set of parameters designed to achieve such an ablation; and applying a nonablative dose of energy to a second portion of the designated treatment volume with the probe using at least one different pulse sequence than that used on the first portion and a set of parameters designed to achieve such a nonlethal dose.

Abstract: A device including a focused ultrasound probe, a first balloon, and a second balloon. The first balloon can be located at least partially inside the second balloon. The inner balloon can be configured to act as a fluid interface, a mechanism for cooling, and a mechanism for changing tissue depth of a focal point of the probe. The second balloon can be filed with a thermosensitive hydrogel configured to turn from a fluid at room temperature to a gel at physiologic temperatures. The first and second balloons can be configured to create a fluid interface between the probe and targeted tissue of a patient.

Abstract: An apparatus for and a method of performing sonasurgery may include a room coordinate system and at least one probe with localization technology. A position of the probe may be tracked continuously during the course of a procedure so that its position is known and updated relative to a preoperative MRI/CT.

Abstract: A system for providing focused ultrasound may include a focused ultrasound probe including at least one transducer. At least one variable volume fluid bladder may be positioned between at least a portion of the transducer and tissue to be treated. The system may further include a reservoir containing fluid and a first pump operatively connected to the bladder and the reservoir. The first pump may be configured to move fluid into the bladder. A second pump may be operatively connected to the bladder and the reservoir. The second pump may be configured to move fluid out of the bladder.

Abstract: An ultrasound system includes a sheath having a distal end and a proximal end. The distal end may include an opening configured to allow the passage of a fluid between the sheath and a chamber in a patient. The proximal end may include one or more ports configured to allow the passage of the fluid into and out of the sheath. A probe may include a shaft and an ultrasound transducer coupled to the shaft. The probe may be configured for insertion into the proximal end of the sheath.

Abstract: A system for providing ultrasound includes a drive shaft having a proximal end and a distal end. One or more motors are positioned at or near the proximal end of the drive shaft. One or more pair of jaws or one or more joints are mounted on or near the distal end of the drive shaft. One or more transducers are configured to generate thermal or cavitational lesions with ultrasound. Each transducer is mounted to one of the jaws or is operatively connected to the joint.