Patents by Inventor Mark Cassidy
Mark Cassidy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11626200Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: GrantFiled: February 17, 2020Date of Patent: April 11, 2023Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Patent number: 10733726Abstract: Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis.Type: GrantFiled: July 9, 2018Date of Patent: August 4, 2020Assignee: H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTEInventors: Mark Cassidy Cridlin Lloyd, Marilyn Yuanxin Ma Bui, Katarzyna Ann Rejniak, Munish Puri
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Publication number: 20200184193Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: ApplicationFiled: February 17, 2020Publication date: June 11, 2020Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Patent number: 10565430Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: GrantFiled: September 8, 2017Date of Patent: February 18, 2020Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Publication number: 20190087954Abstract: Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis.Type: ApplicationFiled: July 9, 2018Publication date: March 21, 2019Inventors: Mark Cassidy Cridlin Lloyd, Marilyn Yuanxin Ma Bui, Katarzyna Ann Rejniak, Munish Puri
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Publication number: 20190054451Abstract: The invention provides a catalyst comprising iron oxide, nickel, ceria or palladium supported on stainless steel foam. The catalyst is effective in oxidising aromatic compounds such as toluene and o-cresol and, advantageously, is particularly effective when the oxidation is carried out at elevated temperatures that correspond to temperatures attained in areas of the aircraft where cabin air is recirculated.Type: ApplicationFiled: February 10, 2017Publication date: February 21, 2019Inventors: John Thomas Sirr IRVINE, Mark CASSIDY, Sneh JAIN
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Patent number: 10049447Abstract: Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis.Type: GrantFiled: November 6, 2014Date of Patent: August 14, 2018Assignee: H. Lee Moffitt Cancer Center and Research Insititute, Inc.Inventors: Mark Cassidy Cridlin Lloyd, Marilyn Yuanxin Ma Bui, Katarzyna Anna Rejniak, Munish Puri
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Publication number: 20180075284Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: ApplicationFiled: September 8, 2017Publication date: March 15, 2018Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Patent number: 9760760Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: GrantFiled: January 18, 2013Date of Patent: September 12, 2017Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Publication number: 20160314580Abstract: Systems and methods for personalized cancer therapy using analysis of pathology slides to target regions in a single sample that interrogates the feature data of a relatively large number of cells. The disclosure describes pathology case review tools of the future which include analysis, visualization and prediction modeling to provide novel information to the pathologist for the diagnosis of disease. This disclosure further describes a user interface to assist the physicians that make that diagnosis, pathologists. Complex computer learning algorithms will combine and mine these data sets to recommend optimal treatment strategies. A computer interface is provided which allows a pathologist to access those data instantly to make a more informed and accurate diagnosis.Type: ApplicationFiled: November 6, 2014Publication date: October 27, 2016Inventors: Mark Cassidy Cridlin Lloyd, Marilyn Yuanxin Ma Bui, Katarzyna Anna Rejniak, Munish Puri
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Publication number: 20150003716Abstract: Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The present disclosure is directed to a desktop slide scanner, which enables pathologists to scan slides at a touch of a button. Included is a workflow for reliable imaging, diagnosis, quantification, management, and sharing of a digital pathology library. Also disclosed herein is an analysis framework that provides for pattern recognition of biological samples represented as digital images to automatically quantitatively score normal cell parameters against disease state parameters. The framework provides a pathologist with an opportunity to see what the algorithm is scoring, and simply agree, or edit the result. This framework offers a new tool to enhance the precision of the current standard of care.Type: ApplicationFiled: January 18, 2013Publication date: January 1, 2015Inventors: Mark Cassidy Cridlin Lloyd, Marilyn M. Bui
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Patent number: 7951509Abstract: A solid oxide fuel cell stack includes a plurality of solid oxide fuel cells, wherein each solid oxide fuel cell comprises an electrolyte located between an anode electrode and a cathode electrode, a plurality of gas separators, and at least one compliant cathode contact material. The contact material may be a metallic felt, foam or mesh, an electrically conductive glass or an electrically conductive ceramic felt located between at least one of the plurality of gas separators and a cathode electrode of an adjacent solid oxide fuel cell.Type: GrantFiled: April 2, 2007Date of Patent: May 31, 2011Assignee: Bloom Energy CorporationInventors: Mark Cassidy, Stephen Couse
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Patent number: 7892691Abstract: A solid oxide fuel cell component (12) comprises a plurality of solid oxide fuel cells (24) arranged in spaced apart relationship, and in electrical series, on a surface of the porous gas permeable support structure (16). Each solid oxide fuel cell (24) comprises a dense gas tight electrolyte member (28), a porous gas permeable first electrode (26) and a porous gas permeable second electrode (30). Each electrolyte (28) is arranged in contact with a corresponding one of the first electrodes (26), each second electrode (30) is arranged in contact with a corresponding one of the electrolytes (28). Each of the first electrodes (26) is arranged in contact with the surface of the support structure (16). The interconnectors (32), the peripheral seal layer (34) and the electrolytes (28) are arranged to encapsulate all of the first electrodes (26) except for the surfaces of the first electrodes (26) in contact with the surface of the support structure (16) to prevent leakage of reactant from the first electrodes (16).Type: GrantFiled: January 27, 2010Date of Patent: February 22, 2011Assignee: Rolls-Royce plcInventors: Michael J. Day, Frederick J. Gardner, Mark Cassidy, Nigel Brandon, Nigel T. Hart
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Patent number: 7732075Abstract: A solid oxide fuel cell component (12) comprises a plurality of solid oxide fuel cells (24) arranged in spaced apart relationship, and in electrical series, on a surface of the porous gas permeable support structure (16). Each solid oxide fuel cell (24) comprises a dense gas tight electrolyte member (28), a porous gas permeable first electrode (26) and a porous gas permeable second electrode (30). Each electrolyte (28) is arranged in contact with a corresponding one of the first electrodes (26), each second electrode (30) is arranged in contact with a corresponding one of the electrolytes (28). Each of the first electrodes (26) is arranged in contact with the surface of the support structure (16). The interconnectors (32), the peripheral seal layer (34) and the electrolytes (28) are arranged to encapsulate all of the first electrodes (26) except for the surfaces of the first electrodes (26) in contact with the surface of the support structure (16) to prevent leakage of reactant from the first electrodes (16).Type: GrantFiled: March 17, 2009Date of Patent: June 8, 2010Assignee: Rolls-Royce plcInventors: Michael J. Day, Frederick J. Gardner, Mark Cassidy, Nigel Brandon, Nigel T. Hart
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Publication number: 20100129727Abstract: A solid oxide fuel cell component (12) comprises a plurality of solid oxide fuel cells (24) arranged in spaced apart relationship, and in electrical series, on a surface of the porous gas permeable support structure (16). Each solid oxide fuel cell (24) comprises a dense gas tight electrolyte member (28), a porous gas permeable first electrode (26) and a porous gas permeable second electrode (30). Each electrolyte (28) is arranged in contact with a corresponding one of the first electrodes (26), each second electrode (30) is arranged in contact with a corresponding one of the electrolytes (28). Each of the first electrodes (26) is arranged in contact with the surface of the support structure (16). The interconnectors (32), the peripheral seal layer (34) and the electrolytes (28) are arranged to encapsulate all of the first electrodes (26) except for the surfaces of the first electrodes (26) in contact with the surface of the support structure (16) to prevent leakage of reactant from the first electrodes (16).Type: ApplicationFiled: January 27, 2010Publication date: May 27, 2010Applicant: ROLLS-ROYCE PLCInventors: Michael J. Day, Frederick J. Gardner, Mark Cassidy, Nigel Brandon, Nigel T. Hart
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Publication number: 20090291346Abstract: A solid oxide electrolyzer cell or a solid oxide reversible fuel cell includes a solid oxide electrolyte. It may also include at least one of a first gadolinia doped ceria interfacial layer in contact with a first side of the electrolyte and a second gadolinia doped ceria interfacial layer in contact with a second side of the electrolyte. It may also include a fuel electrode including a cermet containing nickel and one or both of a doped zirconia and gadolinia doped ceria. It may also include an oxidant electrode including an LSM and one or both of a doped zirconia and gadolinia doped ceria.Type: ApplicationFiled: August 5, 2009Publication date: November 26, 2009Inventors: Darren Hickey, Mark Cassidy
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Publication number: 20090194219Abstract: A solid oxide fuel cell component (12) comprises a plurality of solid oxide fuel cells (24) arranged in spaced apart relationship, and in electrical series, on a surface of the porous gas permeable support structure (16). Each solid oxide fuel cell (24) comprises a dense gas tight electrolyte member (28), a porous gas permeable first electrode (26) and a porous gas permeable second electrode (30). Each electrolyte (28) is arranged in contact with a corresponding one of the first electrodes (26), each second electrode (30) is arranged in contact with a corresponding one of the electrolytes (28). Each of the first electrodes (26) is arranged in contact with the surface of the support structure (16). The interconnectors (32), the peripheral seal layer (34) and the electrolytes (28) are arranged to encapsulate all of the first electrodes (26) except for the surfaces of the first electrodes (26) in contact with the surface of the support structure (16) to prevent leakage of reactant from the first electrodes (16).Type: ApplicationFiled: March 17, 2009Publication date: August 6, 2009Inventors: MICHAEL J. DAY, FREDERICK J. GARDNER, MARK CASSIDY, NIGEL BRANDON, NIGEL T. HART
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Patent number: 7531260Abstract: A solid oxide fuel cell component (12) comprises a plurality of solid oxide fuel cells (24) arranged in spaced apart relationship, and in electrical series, on a surface of the porous gas permeable support structure (16). Each solid oxide fuel cell (24) comprises a dense gas tight electrolyte member (28), a porous gas permeable first electrode (26) and a porous gas permeable second electrode (30). Each electrolyte (28) is arranged in contact with a corresponding one of the first electrodes (26), each second electrode (30) is arranged in contact with a corresponding one of the electrolytes (28). Each of the first electrodes (26) is arranged in contact with the surface of the support structure (16). The interconnectors (32), the peripheral seal layer (34) and the electrolytes (28) are arranged to encapsulate all of the first electrodes (26) except for the surfaces of the first electrodes (26) in contact with the surface of the support structure (16) to prevent leakage of reactant from the first electrodes (16).Type: GrantFiled: April 3, 2003Date of Patent: May 12, 2009Assignee: Rolls-Royce plcInventors: Michael J. Day, Frederick J. Gardner, Mark Cassidy, Nigel Brandon, Nigel T. Hart
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Patent number: 7399546Abstract: A solid oxide fuel cell (10) comprises an anode electrode (12), a cathode electrode (14) and an electrolyte (16) between the anode electrode (12) and the cathode electrode (14). A gaseous fuel is supplied to an anode chamber (18) partially defined by the anode electrode (12) and a gaseous oxidant is supplied to a cathode chamber (20) partially defined by the cathode electrode (14). The electrolyte (16) comprises a first dense non-porous layer (22), a second porous layer (24) on the first dense non-porous layer (22) and a third dense non-porous layer (26) on the second porous layer (24). The anode electrode (12) is arranged on the first dense non-porous layer (22) and the cathode electrode (14) is arranged on the third dense non-porous layer (26). The second porous layer (24) acts as a buffer between the first dense non-porous layer (22) and the third dense non-porous layer (26) to prevent defects propagating between the layers (22,26) and to prevent fuel and oxidant leaking through the electrolyte (16).Type: GrantFiled: December 21, 2005Date of Patent: July 15, 2008Assignee: Rolls-Royce plcInventors: Nigel T Hart, Gary J Wright, Gerard D Agnew, Mark Cassidy
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Publication number: 20070231676Abstract: A solid oxide fuel cell stack includes a plurality of solid oxide fuel cells, wherein each solid oxide fuel cell comprises an electrolyte located between an anode electrode and a cathode electrode, a plurality of gas separators, and at least one compliant cathode contact material. The contact material may be a metallic felt, foam or mesh, an electrically conductive glass or an electrically conductive ceramic felt located between at least one of the plurality of gas separators and a cathode electrode of an adjacent solid oxide fuel cell.Type: ApplicationFiled: April 2, 2007Publication date: October 4, 2007Inventors: Mark Cassidy, Stephen Couse