Abstract: This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is useful for multiplexed analysis of a plurality of analytes in a sample. The coupled complex particles carrying on their surface fluorescent nanoparticles, methods of preparing such polymer particles, and various applications and methods of using such particles are claimed.

Abstract: A handheld head treatment device and method for reducing hair loss and stimulating hair growth by supplying current and laser light to a user's head. The device includes a current generator disposed within a housing configured to output a current for passage into the user's head and a laser source and guide means disposed within the housing configured to output and direct respective portions of the laser beam outward from the hair treatment device toward the user's head when the hair treatment device is in use. The method comprises the step of directing a series of different current and laser treatments to a portion of the scalp wherein the programmed current treatments are sequentially administered and include a continuous and pulsed direct current treatment.

Abstract: A method for the multiplexed diagnosis of a plurality of different biomolecules in a fluid sample substantially simultaneously is provided. In accordance with a method of the invention, a substantial fraction of biomolecules in a fluid sample are complexed with a universal label and a secondary labeling reagent. Flow cytometric measurements may be used to identify and quantify, in real-time, by detecting the secondary reagent and universal label present in any of said complexes. The inventive technology enables the simultaneous, and automated, detection and interpretation of multiple biomolecules while also reducing the cost of performing diagnostic and genetic assays.

Abstract: A freestanding self-propelled device for moving objects. The device includes a chassis having lower frame portions and upright frame portions. A single motor-driven drive wheel is centrally located between the lateral ends of the chassis and coupled to the chassis so as to be pivotable about a substantially vertical axis. The drive wheel is located between sets of support wheels coupled to the lower frame portion of the chassis. In combination, the drive wheel and the support wheels result in the device being freestanding. The drive wheel projects below the sets of support wheels so that the device is supported by the drive wheel and by only one of each set of support wheels at any given time, thereby establishing a three-point contact with the surface supporting the device. A tiller equipped with controls is pivotably coupled to the drive wheel for pivoting the drive wheel about its vertical axis.

Abstract: A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset, exposing the beadset to a clinical sample, and analyzing the combined sample/beadset by flow cytometry. Flow cytometric measurements are used to classify, in real-time, beads within an exposed beadset and textual explanations, based on the accumulated data obtained during real-time analysis, are generated for the user. The inventive technology enables the simultaneous, and automated, detection and interpretation of multiple biomolecules or DNA sequences in real-time while also reducing the cost of performing diagnostic and genetic assays.

Abstract: A biochemical image is derived from specimens, preferably obtained from a statistically relevant sample of a subject population sharing a common characteristic. The biochemical images for one or more conditions present in the subject population and/or one or more test subjects are determined and made available for computer implemented diagnostic evaluations and medical research. In addition to using the information for general research purposes, information from the images may be used to classify diseases and disease states.

Abstract: This invention is based on the observation that all diseases may be diagnosed by analysis of at least about 200-300 biochemicals present in a patient's blood. In addition, disease progression may also be predicted from the profile of biochemicals in the blood. This invention takes advantage of rapid automated methods for determining the concentrations of biochemicals in the blood of a patient and compares these concentrations to a database which includes information derived from a multi-year study of approximately 200,000 persons. From the correlations found between biochemical concentrations in the blood and the existence of disease states, this invention permits the diagnosis of a present disease state in the patient and has the capacity to predict the emergence of future disease states in the patient.

Abstract: A freestanding self-propelled device for moving objects. The device includes a chassis having lower frame portions and upright frame portions. A single motor-driven drive wheel is centrally located between the lateral ends of the chassis and coupled to the chassis so as to be pivotable about a substantially vertical axis. The drive wheel is located between sets of support wheels coupled to the lower frame portion of the chassis. In combination, the drive wheel and the support wheels result in the device being freestanding. The drive wheel projects below the sets of support wheels so that the device is supported by the drive wheel and by only one of each set of support wheels at any given time, thereby establishing a three-point contact with the surface supporting the device. A tiller equipped with controls is pivotably coupled to the drive wheel for pivoting the drive wheel about its vertical axis.

Abstract: An apparatus adapted for use with a trans-esophageal probe. The apparatus comprises a disinfecting unit and a storage unit, each of which includes a tubular housing having an interior, upper and lower ends, and an opening at the upper end for access to the interior. The disinfecting unit includes a support above the upper end of its housing for supporting a handle of a probe whose probe end is within the interior of the housing. The interior of the disinfecting unit is adapted to contain a fluid, and is equipped with a fluid level indicator and a drain for draining the fluid from the housing. The storage unit includes an enclosure removably mounted to the upper end of its housing for enclosing the handle end of a probe whose probe end is within the interior of the housing. Both units further include a support for a connector of a probe placed in the unit.

Abstract: A speech processing system for the generation of speaker specific text output. To automatically generate a transcript of a trial, hearing, or. meeting, the system uses microphones dedicated to specific speakers along with one or more computers with speech recognition software assigned to each microphone. The system tracks the occurrences of speech and assembles a transcript of the participant's spoken words including the speaker's identity and a text version of the spoken words in the order the words were spoken.

Abstract: Internal standards and controls are provided for detecting and/or compensating for sources of measurement error in multiplexed diagnostic and genetic assays. The internal standards include subsets of particles comprising ligand binding partner specific for analytes of interest, each subset having a different known amount of ligand binding partner. Internal controls include subsets of particles comprising ligand binding partner chosen to provide information relating to high-dose hook effects, dilutional linearity, interfering assay factors, or sample or reagent omission.

Abstract: A method of making chip stacks begins with the formation of a plurality of panels having apertures therein and conductive pads on opposite sides thereof. Solder paste is deposited on the conductive pads prior to mounting plastic packaged IC chips within each of the apertures in each of the panels so that opposite leads thereof reside on the conductive pads at opposite sides of the apertures. The plural panels are then assembled into a stack, such as by use of a tooling jig which aligns the various panels and holds them together in compressed fashion. The assembled panel stack is heated so that the solder paste solders the leads of the packaged chips to the conductive pads and interfacing conductive pads of adjacent panels together, to form a panel stack comprised of a plurality of chip package stacks. Following cleaning of the panel stack to remove solder flux residue, the individual chip package stacks are separated from the panel stack by cutting and breaking the stack.

Abstract: A computerized technique for generating masters for embossing and printing color images with local regions of variation of an optical characteristic such as reflectance is disclosed. The color image is read into a computer and displayed on the computer screen. An electronic embossing mask is created for each local region which is to have a preselected optical variation. The line pattern is designated for each local region mask and an embossing film is exposed with each electronic embossing mask for creating in the embossing film a composite image including each line pattern in each local region. A plurality of electronic color separation masks are generated from the original color image, and each of these is combined with an electronic embossing mask to form an electronic line color separation mask having line patterns which correspond to those designated for the local regions.

Abstract: For making rapid, non-destructive permeability measurements in the field, a portable minipermeameter of the kind having a manually-operated gas injection tip is provided with a microcomputer system which operates a flow controller to precisely regulate gas flow rate to a test sample, and reads a pressure sensor which senses the pressure across the test sample. The microcomputer system automatically turns on the gas supply at the start of each measurement, senses when a steady-state is reached, collects and records pressure and flow rate data, and shuts off the gas supply immediately after the measurement is completed. Preferably temperature is also sensed to correct for changes in gas viscosity. The microcomputer system may also provide automatic zero-point adjustment, sensor calibration, over-range sensing, and may select controllers, sensors, and set-points for obtaining the most precise measurements. Electronic sensors may provide increased accuracy and precision.