Abstract: Bicyclopentanyl compounds having the formula (I), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, R5, R6, A1, A2, and X are as defined herein, compositions including the compounds, processes of manufacturing the compounds, and methods of using the compounds. The compound may be used for treatment of a disorder, disease, or disability associated with Kv7.2 in a subject in need thereof, wherein the disorder, disease, or disability is selected from behavioral disorders, mood disorders, neurodevelopmental disorders, intellectual disability, epilepsies, neurodegenerative diseases, pain, migraine, and tinnitus.

Abstract: The present invention is directed to wallboard assemblies containing a gypsum panel and a method of making such wallboard assemblies. In one embodiment, the wallboard assembly comprises a gypsum panel containing a gypsum core and at least one facing material. The wallboard assembly and/or the gypsum panel may be fire resistant. The methods of the present invention are directed to making the aforementioned wallboard assemblies.

Abstract: The present invention is directed to a plaster composition with a reduced carbon footprint and a method of making and using such plaster composition. In one aspect, the plaster composition may include a workability composition and a binder. When hydrated with water, a hydrated plaster composition may have enhanced workability, enhanced surface texture, enhanced finish, and may have a reduced carbon footprint as compared to a traditional plaster composition.

Abstract: The invention provides new heteroaromatic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: The invention provides new bicyclopentanyl compounds having the general formula (I), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: The invention provides new heterocyclic compounds having the general formula (I?), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: The invention provides new heterocyclic compounds having the general formula (I), or a solvate or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, R4, R5, R6 and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: An aircraft includes the aircraft component. The aircraft component includes an outer skin portion, a plurality of major stiffeners, and a plurality of minor stiffeners. The outer skin portion has an interior side and an exterior side configured to define an exterior boundary of the aircraft. The major stiffeners are integral with the outer skin portion and extend out from the interior side. The major stiffeners are configured to resist global deflection of the aircraft component in response to a bird strike on the aircraft component. The minor stiffeners are disposed between the major stiffeners, are integral with the outer skin portion, and extend out from the interior side. The minor stiffeners are configured to resist perforation of the aircraft component in response to the bird strike on the aircraft component.

Abstract: A composite reinforcement structure including a first skin having a first end and a second end and a second skin having a first end and a second end. The first end of the first skin and the first end of the second skin are coupled. A corrugated spar is disposed between the first skin and the second skin and is bonded to the first skin and the second skin.

Abstract: Aligned carbon nanotube are synthesized using an electric potential generated by a thermocouple and strips of first and second materials. The first and second materials have different chemical compositions, and include at least one of an oxide and a metal. A catalyst is deposited on and/or around the materials, and can also be deposited on the substrate. The substrate is exposed to the electric potential in the presence of a carbon-containing gas during chemical vapor deposition. This causes carbon nanotubes to grow from the catalyst, in alignment with the electric potential.

Abstract: The present invention discloses compositions and methods for generating engineered catalysts and synthesizing semiconducting single wall carbon nanotubes using the catalysts Carbon nanotubes (CNTs). The CNTS are either metallic or semiconducting, with diameters controlled by an engineered catalyst to selectively synthesizes the semiconducting CNT. The engineered catalyst consists of two types of metals, a high melting point metal and an active transition metal. Each of the metals remains solid state during a growth of semiconducting CNTs, and each is present as nanoparticles, having sizes between 0.5 nm and 10 nm. The ratio of the high melting point metal with respect to the active transition metal is preferably between 1:0.25 and 1:10.

Abstract: Aircraft components and aircraft are provided. An aircraft includes the aircraft component. The aircraft component includes an outer skin portion, a plurality of major stiffeners, and a plurality of minor stiffeners. The outer skin portion has an interior side and an exterior side configured to define an exterior boundary of the aircraft. The major stiffeners are integral with the outer skin portion and extend out from the interior side. The major stiffeners are configured to resist global deflection of the aircraft component in response to a bird strike on the aircraft component. The minor stiffeners are disposed between the major stiffeners, are integral with the outer skin portion, and extend out from the interior side. The minor stiffeners are configured to resist perforation of the aircraft component in response to the bird strike on the aircraft component.

Abstract: Provided is a process for recovering metals from solid radioactive waste, preferably uranium, cesium, mercury, thorium, rare earths or combinations thereof. The process comprises a leaching step and a separation step. The leaching step comprises contacting the solid radioactive waste with an aqueous inorganic acid and a leaching salt to produce a mixture of a metal-rich leachate and a metal-poor waste, which are separated in the separation step. Also provided is a process for recovering metals from solid radioactive waste comprising an attrition step, a leaching step, a washing step, a combination step and a recovery step.

Abstract: A composite reinforcement structure including a first skin having a first end and a second end and a second skin having a first end and a second end. The first end of the first skin and the first end of the second skin are coupled. A corrugated spar is disposed between the first skin and the second skin and is bonded to the first skin and the second skin.

Abstract: An inventory tracking assembly includes a holder that may restrain an article of clothing. A tracking unit is coupled to the holder and the tracking unit stores information pertaining to the article of clothing. The tracking unit displays the information such that the tracking unit may communicate the information to a user thereby facilitating the article of clothing to be tracked and identified.

Abstract: Provided is a process for recovering metals from solid radioactive waste, preferably uranium, cesium, mercury, thorium, rare earths or combinations thereof. The process comprises a leaching step and a separation step. The leaching step comprises contacting the solid radioactive waste with an aqueous inorganic acid and a leaching salt to produce a mixture of a metal-rich leachate and a metal-poor waste, which are separated in the separation step. Also provided is a process for recovering metals from solid radioactive waste comprising an attrition step, a leaching step, a washing step, a combination step and a recovery step.

Abstract: The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1 -(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

Abstract: The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

Abstract: The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Particularly, compositions and methods involving administration, either simultaneously or sequentially, of pharmaceutical combinations comprising (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide with other compounds, to patients suffering from cancer are described.

Abstract: This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-?. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.