Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: The present disclosure relates to the identification of a group of microorganisms, which are relatively abundant in the microbial communities associated with fruits and vegetables typically consumed raw and therefore transient or permanent members of the human microbiota. These microbes are used to augment the effects of additional probiotic strains. The consumption of mixtures of these microbes at relevant doses will produce a beneficial effect in the host. Therapeutic methods of the disclosure involve the use of live microorganisms or metabolites derived from said microorganisms to establish a microbial composition in the mammalian host that will provide a health benefit to a mammal in need thereof.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: Recombinant bacteria capable of producing and secreting therapeutically active EGF, pharmaceutical compositions thereof, and methods of treating disorders are disclosed.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: This disclosure provides for compositions (e.g., pharmaceutical compositions, dietary supplements, medical foods and food stuff), comprising combinations of live microbe populations for the treatment and/or prevention of immune system disorders and conditions related to inflammation, including both pathogen assisted conditions and conditions that are independent of pathogens. Included with the present disclosure are methods for use of the compositions, and methods for selecting microbial entities to formulate the compositions of the disclosure.

Abstract: An adaptable spinal facet joint prosthesis may include a pedicle fixation element; a laminar fixation element; and a facet joint bearing surface having a location adaptable with respect at least one of the pedicle fixation element and the laminar fixation element. Methods of implanting an adaptable spinal facet joint prosthesis may include determining a desired position for a facet joint bearing surface; and attaching a prosthesis comprising a facet joint bearing surface to a pedicle portion of a vertebra and a lamina portion of a vertebra to place the facet joint bearing surface in the desired position. A facet joint prosthesis implant tool may include a tool guide adapted to guide a vertebra cutting tool; and first and second fixation hole alignment elements extending from the saw guide. Systems for treating spinal pathologies may include intervertebral discs in combination with spinal and facet joint prostheses.

Abstract: An adaptable spinal facet joint prosthesis may include a pedicle fixation element; a laminar fixation element; and a facet joint bearing surface having a location adaptable with respect at least one of the pedicle fixation element and the laminar fixation element. Methods of implanting an adaptable spinal facet joint prosthesis may include determining a desired position for a facet joint bearing surface; and attaching a prosthesis comprising a facet joint bearing surface to a pedicle portion of a vertebra and a lamina portion of a vertebra to place the facet joint bearing surface in the desired position. A facet joint prosthesis implant tool may include a tool guide adapted to guide a vertebra cutting tool; and first and second fixation hole alignment elements extending from the saw guide. Systems for treating spinal pathologies may include intervertebral discs in combination with spinal and facet joint prostheses.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements. The prosthesis can include a crossbar having first and second ends. A first caudal prosthesis can be attached to the first end of the crossbar, while a second caudal prosthesis can be attached to the second end of the crossbar. A first crossbar mount can be positioned on the crossbar near the first caudal prosthesis, while a second crossbar mount can be positioned on the crossbar near the second caudal prosthesis. A first cephalad prosthesis can extend from the first crossbar mount, while a second cephalad prosthesis can extend from the second crossbar mount.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements. The prosthesis can include a crossbar having first and second ends. A first caudal prosthesis can be attached to the first end of the crossbar, while a second caudal prosthesis can be attached to the second end of the crossbar. A first crossbar mount can be positioned on the crossbar near the first caudal prosthesis, while a second crossbar mount can be positioned on the crossbar near the second caudal prosthesis. A first cephalad prosthesis can extend from the first crossbar mount, while a second cephalad prosthesis can extend from the second crossbar mount.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements. The prosthesis can include a crossbar having first and second ends. A first caudal prosthesis can be attached to the first end of the crossbar, while a second caudal prosthesis can be attached to the second end of the crossbar. A first crossbar mount can be positioned on the crossbar near the first caudal prosthesis, while a second crossbar mount can be positioned on the crossbar near the second caudal prosthesis. A first cephalad prosthesis can extend from the first crossbar mount, while a second cephalad prosthesis can extend from the second crossbar mount.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements. The prosthesis can include a crossbar having first and second ends. A first caudal prosthesis can be attached to the first end of the crossbar, while a second caudal prosthesis can be attached to the second end of the crossbar. A first crossbar mount can be positioned on the crossbar near the first caudal prosthesis, while a second crossbar mount can be positioned on the crossbar near the second caudal prosthesis. A first cephalad prosthesis can extend from the first crossbar mount, while a second cephalad prosthesis can extend from the second crossbar mount.

Abstract: The present disclosure relates generally to closure mechanisms, such as a closure latch device for clamping a band. The closure latch comprises a first and second latch member engaged to pivot relative to each other. Certain embodiments relate to methods of clamping a band. Certain embodiments relate to methods of manufacturing a clamping device.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements.

Abstract: Modular spinal prosthesis having one of both of adaptable and configurable components are provided. The modular spinal prosthesis described herein provide an artificial articular configuration to replace damaged, worn or otherwise removed spinal facet elements.

Abstract: The present disclosure relates generally to closure mechanisms, such as a closure latch device for clamping a band. The closure latch comprises a first and second latch member engaged to pivot relative to each other. Certain embodiments relate to methods of clamping a band. Certain embodiments relate to methods of manufacturing a clamping device.