Patents by Inventor Mark Chee

Mark Chee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
    Patent number: 6027880
    Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: February 22, 2000
    Assignee: Affymetrix, Inc.
    Inventors: Maureen T. Cronin, Charles Garrett Miyada, Earl A. Hubbell, Mark Chee, Stephen P. A. Fodor, Xiaohua C. Huang, Robert J. Lipshutz, Peter E. Lobban, Macdonald S. Morris, Edward L. Sheldon
  • Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
    Patent number: 5861242
    Abstract: The invention provides an array of oligonucleotide probes immobilized on a solid support for analysis of a target sequence from a human immunodeficiency virus. The array comprises at least four sets of oligonucleotide probes 9 to 21 nucleotides in length. A first probe set has a probe corresponding to each nucleotide in a reference sequence from a human immunodeficiency virus. A probe is related to its corresponding nucleotide by being exactly complementary to a subsequence of the reference sequence that includes the corresponding nucleotide. Thus, each probe has a position, designated an interrogation position, that is occupied by a complementary nucleotide to the corresponding nucleotide. The three additional probe sets each have a corresponding probe for each probe in the first probe set. Thus, for each nucleotide in the reference sequence, there are four corresponding probes, one from each of the probe sets.
    Type: Grant
    Filed: January 9, 1997
    Date of Patent: January 19, 1999
    Assignee: Affymetrix, Inc.
    Inventors: Mark Chee, Thomas R. Gingeras, Stephen P. A. Fodor, Earl A. Hubble, MacDonald S. Morris
  • Polymorphisms in the glucose-6 phosphate dehydrogenase locus
    Patent number: 5856104
    Abstract: The invention provides nucleic acid segments of the glucose-6 phosphate dehydrogenase locus of the human genome including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as forensics, paternity testing, medicine and genetic analysis.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: January 5, 1999
    Assignee: Affymetrix, Inc.
    Inventors: Mark Chee, Jian-Bing Fan
  • Arrays of nucleic acid probes on biological chips
    Patent number: 5837832
    Abstract: DNA chips containing arrays of oligonucleotide probes can be used to determine whether a target nucleic acid has a nucleotide sequence identical to or different from a specific reference sequence. The array of probes comprises probes exactly complementary to the reference sequence, as well as probes that differ by one or more bases from the exactly complementary probes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: November 17, 1998
    Assignee: Affymetrix, Inc.
    Inventors: Mark Chee, Maureen T. Cronin, Stephen P. A. Fodor, Xiaohua X. Huang, Earl A. Hubbell, Robert J. Lipshutz, Peter E. Lobban, MacDonald S. Morris, Edward L. Sheldon