Patents by Inventor Mark Cornebise

Mark Cornebise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID AMINES
    Publication number: 20260109732
    Abstract: Provided are lipid amine compounds which are useful in the preparation of lipid nanoparticle compositions for delivery of therapeutic or prophylactic payload into cells.
    Type: Application
    Filed: October 28, 2022
    Publication date: April 23, 2026
    Inventors: Mohindra Seepersaud, Matthew Crawford, Daniel Tate, Mark Cornebise
  • Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12595226
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 7, 2026
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Souvik Biswas, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20260078082
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: July 21, 2025
    Publication date: March 19, 2026
    Inventors: Kerry E. BENENATO, Mark CORNEBISE
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20260069549
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: April 25, 2025
    Publication date: March 12, 2026
    Inventors: Kerry E. BENENATO, Ellalahewage S. KUMARASINGHE, Mark CORNEBISE
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20260055050
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: April 9, 2025
    Publication date: February 26, 2026
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
  • LIPID NANOPARTICLE COMPOSITIONS COMPRISING PHOSPHOLIPID DERIVATIVES AND RELATED USES
    Publication number: 20250375389
    Abstract: The present disclosure provides lipid assemblies suitable for delivery of therapeutic agents to hematopoietic stem and progenitor cells (HSPCs), wherein the lipid assemblies comprise a phosphatidylserine phospholipid. The present disclosure also provides therapeutic and diagnostic uses related to the lipid assemblies.
    Type: Application
    Filed: July 28, 2023
    Publication date: December 11, 2025
    Inventors: Jaclyn MILTON, Mohindra SEEPERSAUD, Karthik RAMACHANDRAN, Russell B. UMSTEAD, Calvin Loishiye MARAMBO, Mark CORNEBISE
  • LIPID AMINES
    Publication number: 20250281419
    Abstract: The present invention relates to lipid amine compounds of formula (A1) which are useful in the preparation of lipid nanoparticle compositions for delivery of therapeutic or prophylactic payload into cells.
    Type: Application
    Filed: October 28, 2022
    Publication date: September 11, 2025
    Inventors: Mohindra Seepersaud, Matthew Crawford, Daniel Tate, Mark Cornebise, Christopher Karl McLaughlin, Ana Cadete Pires
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12404232
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: September 2, 2025
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20250228777
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: December 18, 2024
    Publication date: July 17, 2025
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12324859
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: June 10, 2025
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12312293
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: May 27, 2025
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12263248
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: April 1, 2025
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy
  • COMPOSITIONS FOR THE DELIVERY OF PAYLOAD MOLECULES TO AIRWAY EPITHELIUM
    Publication number: 20250049727
    Abstract: The present disclosure provides LNPs comprising payload molecules, e.g., mRNA therapeutics, for the treatment of diseases or disorders, which would benefit from delivery of payload molecules to airway cells.
    Type: Application
    Filed: November 10, 2022
    Publication date: February 13, 2025
    Inventors: Ana Cadete Pires, Jean C. Sung, Mark Cornebise, Jeffrey Hrkach
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12151995
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: November 26, 2024
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Ellalahewage Sathyajith Kumarasinghe
  • POLYNUCLEOTIDES ENCODING METHYLMALONYL-COA MUTASE FOR THE TREATMENT OF METHYLMALONIC ACIDEMIA
    Publication number: 20240226025
    Abstract: This disclosure relates to messenger RNA (mRNA) therapy for the treatment of methylmalonic acidemia. mRNAs for use in the invention, when administered in vivo, encode methylmalonyl-CoA mutase. mRNA therapies of the disclosure increase and/or restore deficient levels of MUT expression and/or activity in subjects.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 11, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy, Ruchi Jain, Vladimir Presnyak
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20240226026
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 23, 2022
    Publication date: July 11, 2024
    Inventors: Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Mohindra SEEPERSAUD, Michael W. DANNEMAN
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING PROPIONYL-COA CARBOXYLASE ALPHA AND BETA SUBUNITS AND USES THEREOF
    Publication number: 20240216288
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding propionyl-CoA carboxylase alpha (PCCA) and propionyl-CoA carboxylase beta (PCCB). Lipid nanoparticle/mRNA therapies of the invention increase and/or restore deficient levels of PCCA and/or PCCB expression and/or activity in subjects and are useful for the treatment of propionic academia.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 4, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING GLUCOSE-6-PHOSPHATASE AND USES THEREOF
    Publication number: 20240207374
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding glucose-6-phosphatase. Lipid nanoparticle/mRNA therapies of the invention increase and/or restore deficient levels of glucose-6-phosphatase expression and/or activity in subjects and are useful for the treatment of glycogen storage disease type 1a (GSD-Ia). Lipid nanoparticle/mRNA therapies of the invention increase glucose production and reduce the abnormal accumulation of glycogen and glucose-6-phosphate associated with GSD-Ia.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 27, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING PHENYLALANINE HYDROXYLASE AND USES THEREOF
    Publication number: 20240207444
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding phenylalanine hydroxylase.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 27, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES AND POLYNUCLEOTIDES ENCODING ORNITHINE TRANSCARBAMYLASE FOR THE TREATMENT OF ORNITHINE TRANSCARBAMYLASE DEFICIENCY
    Publication number: 20240189449
    Abstract: This disclosure relates to mRNA therapy for the treatment of ornithine transcarbamylase deficiency (OTCD). mRNAs for use in the invention, when administered in vivo, encode human ornithine transcarbamylase (OTC). mRNA therapies of the disclosure increase and/or restore deficient levels of OTC expression and/or activity in subjects. mRNA therapies of the disclosure further decrease levels of toxic ammonia associated with deficient OTC activity in subjects.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 13, 2024
    Inventors: Kerry Benenato, Alicia Anne Bicknell, Mark Cornebise, Athanasios Dousis, Andrew Jacob Giessel, Edward Hennessy, Ruchi Jain, Caroline Köhrer, Stuart Spencer Licht, Kanchana Ravichandran, David Reid