Patents by Inventor Mark Cornebise

Mark Cornebise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12263248
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: April 1, 2025
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy
  • COMPOSITIONS FOR THE DELIVERY OF PAYLOAD MOLECULES TO AIRWAY EPITHELIUM
    Publication number: 20250049727
    Abstract: The present disclosure provides LNPs comprising payload molecules, e.g., mRNA therapeutics, for the treatment of diseases or disorders, which would benefit from delivery of payload molecules to airway cells.
    Type: Application
    Filed: November 10, 2022
    Publication date: February 13, 2025
    Inventors: Ana Cadete Pires, Jean C. Sung, Mark Cornebise, Jeffrey Hrkach
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 12151995
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: November 26, 2024
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Ellalahewage Sathyajith Kumarasinghe
  • POLYNUCLEOTIDES ENCODING METHYLMALONYL-COA MUTASE FOR THE TREATMENT OF METHYLMALONIC ACIDEMIA
    Publication number: 20240226025
    Abstract: This disclosure relates to messenger RNA (mRNA) therapy for the treatment of methylmalonic acidemia. mRNAs for use in the invention, when administered in vivo, encode methylmalonyl-CoA mutase. mRNA therapies of the disclosure increase and/or restore deficient levels of MUT expression and/or activity in subjects.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 11, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy, Ruchi Jain, Vladimir Presnyak
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING PROPIONYL-COA CARBOXYLASE ALPHA AND BETA SUBUNITS AND USES THEREOF
    Publication number: 20240216288
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding propionyl-CoA carboxylase alpha (PCCA) and propionyl-CoA carboxylase beta (PCCB). Lipid nanoparticle/mRNA therapies of the invention increase and/or restore deficient levels of PCCA and/or PCCB expression and/or activity in subjects and are useful for the treatment of propionic academia.
    Type: Application
    Filed: March 24, 2022
    Publication date: July 4, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING GLUCOSE-6-PHOSPHATASE AND USES THEREOF
    Publication number: 20240207374
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding glucose-6-phosphatase. Lipid nanoparticle/mRNA therapies of the invention increase and/or restore deficient levels of glucose-6-phosphatase expression and/or activity in subjects and are useful for the treatment of glycogen storage disease type 1a (GSD-Ia). Lipid nanoparticle/mRNA therapies of the invention increase glucose production and reduce the abnormal accumulation of glycogen and glucose-6-phosphate associated with GSD-Ia.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 27, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES CONTAINING POLYNUCLEOTIDES ENCODING PHENYLALANINE HYDROXYLASE AND USES THEREOF
    Publication number: 20240207444
    Abstract: This disclosure relates to ionizable amino lipid-based lipid nanoparticles for delivery of mRNA encoding phenylalanine hydroxylase.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 27, 2024
    Inventors: Kerry Benenato, Mark Cornebise, Edward Hennessy
  • LIPID NANOPARTICLES AND POLYNUCLEOTIDES ENCODING ORNITHINE TRANSCARBAMYLASE FOR THE TREATMENT OF ORNITHINE TRANSCARBAMYLASE DEFICIENCY
    Publication number: 20240189449
    Abstract: This disclosure relates to mRNA therapy for the treatment of ornithine transcarbamylase deficiency (OTCD). mRNAs for use in the invention, when administered in vivo, encode human ornithine transcarbamylase (OTC). mRNA therapies of the disclosure increase and/or restore deficient levels of OTC expression and/or activity in subjects. mRNA therapies of the disclosure further decrease levels of toxic ammonia associated with deficient OTC activity in subjects.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 13, 2024
    Inventors: Kerry Benenato, Alicia Anne Bicknell, Mark Cornebise, Athanasios Dousis, Andrew Jacob Giessel, Edward Hennessy, Ruchi Jain, Caroline Köhrer, Stuart Spencer Licht, Kanchana Ravichandran, David Reid
  • BRANCHED TAIL LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20230286903
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: February 3, 2023
    Publication date: September 14, 2023
    Inventors: Kerry E. BENENATO, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • COMPOSITIONS FOR THE DELIVERY OF PAYLOAD MOLECULES TO AIRWAY EPITHELIUM
    Publication number: 20230285310
    Abstract: The present disclosure provides LNPs comprising payload molecules, e.g., mRNA therapeutics, for the treatment of diseases or disorders, which would benefit from delivery of payload molecules to airway cells.
    Type: Application
    Filed: August 6, 2021
    Publication date: September 14, 2023
    Inventors: Ana Cadete Pires, Jean C. Sung, Mark Cornebise, Jeffrey Hrkach
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11597698
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 7, 2023
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11220476
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: January 11, 2022
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11066355
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: July 20, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 10857105
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: December 8, 2020
    Assignee: MordernaTX, Inc.
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 10442756
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: October 15, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • Compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 10392341
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: August 27, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170233332
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 17, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170224844
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: April 21, 2017
    Publication date: August 10, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170210698
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 27, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
  • COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170210697
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 27, 2017
    Inventors: Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise