Patents by Inventor Mark D. Brigham

Mark D. Brigham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant virus and preparations thereof
    Patent number: 11332719
    Abstract: The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making same.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 17, 2022
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Mark D. Brigham, Le Cong, Silvana Konermann
  • Functional screening with optimized functional CRISPR-Cas systems
    Patent number: 11001829
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: May 11, 2021
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng Zhang, Silvana Konermann, Mark D. Brigham, Alexandra Trevino
  • FUNCTIONAL SCREENING WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
    Publication number: 20180057810
    Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
    Type: Application
    Filed: March 24, 2017
    Publication date: March 1, 2018
    Inventors: Feng Zhang, Silvana KONERMANN, Mark D. BRIGHAM, Alexandro TREVINO
  • RECOMBINANT VIRUS AND PREPARATIONS THEREOF
    Publication number: 20160068822
    Abstract: The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making same.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 10, 2016
    Inventors: Feng Zhang, Mark D. Brigham, Le Cong, Silvana Konermann
  • Devices comprising muscle thin films and uses thereof in high throughput assays for determining contractile function
    Patent number: 9012172
    Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: April 21, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Adam Walter Feinberg, Patrick W. Alford, Anna Grosberg, Mark D. Brigham, Josue Adrian Goss
  • RECOMBINANT VIRUS AND PREPARATIONS THEREOF
    Publication number: 20140287938
    Abstract: The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making same.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Feng Zhang, Mark D. Brigham, Le Cong, Silvana Konermann
  • HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN
    Publication number: 20120142556
    Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
    Type: Application
    Filed: April 30, 2010
    Publication date: June 7, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Kevin Kit Parker, Adam Walter Feinberg, Patrick W. Alford, Anna Grosberg, Mark D. Brigham, Josue Adrian Goss