Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: Embodiments of the inventive concepts disclosed herein are directed to systems and methods for managing global navigation satellite system (GNSS) receivers. A master GNSS receiver can receive, via an antenna system, a GNSS signal. The master GNSS receiver can determining, using the received GNSS signal, information including positioning, navigation and timing (PNT) or positioning, velocity and time (PVT) information. The master GNSS receiver can generate a master GNSS signal using a signal generator and the determined information, and a message indicating that the master GNSS signal is a trusted GNSS based signal. The master GNSS receiver can communicate, via a distribution hub, the generated master GNSS signal and the message to a plurality of GNSS receivers co-located with the master GNSS receiver, for recovering the PNT or PVT information from the master GNSS signal.

Abstract: A system and method for simultaneous localization and mapping (SLAM), comprising an improved Geometric Dilution of Precision (GDOP) calculation, a reduced set of feature landmarks, the use of Inertial Measurement Units (IMU) to detect measurement motion, and the use of one-time use features and absolute reference landmarks.

Abstract: Present novel and non-trivial optical, laser-based measuring systems and method are disclosed. An optical, laser-based, or LIDAR measuring apparatus is comprised of a radiation receiver/transmitter, a beam-forming optical element, a beam steering device comprised of a deviation optical element and at least one actuator used to steer the deviation optical element in response to drive signal(s) from a processor.

Abstract: The invention relates to a scan mode of operating for a communication system that supports both voice and data communication services. Prior to entering the scan mode, a mobile station (28) provides a message to the fixed network equipment, and particularly a data controller (22) within the fixed network equipment, that it is entering scan mode. When exiting scan mode, the mobile station (28) sends a message to the data controller (22) indicating that it is no longer in scan mode. With knowledge of whether the mobile station (28) is in scan mode, the data controller (22) sends data messages to the mobile station using a preamble. The preamble may include a plurality of short confirmed message packets (606) and each may contain a preamble list of mobile stations to which data messages are scheduled to be sent.

Abstract: The present invention includes an apparatus and a method for transceiver self-diagnostic testing in a communication system. A feedback unit (228, 326) is utilized that allows performance of a loopback test independent of a transmit frequency to receive frequency difference without undue proliferation of circuitry.