Patents by Inventor Mark D. Holtan

Mark D. Holtan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and apparatuses for target molecule detection
    Patent number: 12379346
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Grant
    Filed: December 11, 2023
    Date of Patent: August 5, 2025
    Assignee: Auburn University
    Inventors: Christopher J. Easley, Mark D. Holtan, Subramaniam Somasundaram
  • METHODS AND APPARATUSES FOR TARGET MOLECULE DETECTION
    Publication number: 20240361273
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Application
    Filed: December 11, 2023
    Publication date: October 31, 2024
    Inventors: Christopher J. EASLEY, Mark D. HOLTAN, Subramaniam SOMASUNDARAM
  • Differential circuit for background correction in electrochemical measurements
    Patent number: 11841341
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 12, 2023
    Assignee: Auburn University
    Inventors: Christopher J. Easley, Mark D. Holtan, Subramaniam Somasundaram
  • DIFFERENTIAL CIRCUIT FOR BACKGROUND CORRECTION IN ELECTROCHEMICAL MEASUREMENTS
    Publication number: 20210055260
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Application
    Filed: October 29, 2020
    Publication date: February 25, 2021
    Inventors: Christopher J. EASLEY, Mark D. HOLTAN, Subramaniam SOMASUNDARAM
  • Differential circuit for background correction in electrochemical measurements
    Patent number: 10852274
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: December 1, 2020
    Assignee: Auburn University
    Inventors: Christopher J. Easley, Mark D. Holtan, Subramaniam Somasundaram
  • DIFFERENTIAL CIRCUIT FOR BACKGROUND CORRECTION IN ELECTROCHEMICAL MEASUREMENTS
    Publication number: 20180259483
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 13, 2018
    Inventors: Christopher J. EASLEY, Mark D. HOLTAN, Subramaniam SOMASUNDARAM
  • Thermally resolved molecule assays
    Patent number: 9995680
    Abstract: Provided herein are compositions and methods including the step of thermally scanning a sample that can be used and implemented to detect the presence of and/or concentration of a molecule in a sample.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: June 12, 2018
    Assignee: Auburn University
    Inventors: Christopher J. Easley, Joonyul Kim, Juan Hu, Mark D. Holtan, Subramaniam Somasundaram, Curtis Shannon
  • Thermally Resolved Molecule Assays
    Publication number: 20160131604
    Abstract: Provided herein are compositions and methods including the step of thermally scanning a sample that can be used and implemented to detect the presence of and/or concentration of a molecule in a sample.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 12, 2016
    Inventors: Christopher J. Easley, Joonyul Kim, Juan Hu, Mark D. Holtan, Subramaniam Somasundaram, Curtis Shannon