Patents by Inventor Mark D. Mannie

Mark D. Mannie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aluminum based adjuvants for tolerogenic vaccination
    Patent number: 12569556
    Abstract: The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: March 10, 2026
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • COMPOSITIONS AND METHODS FOR IN VITRO CULTIVATION AND/OR EXPANSION OF REGULATORY T CELLS
    Publication number: 20220380728
    Abstract: FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy.
    Type: Application
    Filed: June 9, 2022
    Publication date: December 1, 2022
    Inventors: Daniel Stephen Wilkinson, Mark D. Mannie
  • Compositions and methods for in vitro cultivation and/or expansion of regulatory T cells
    Patent number: 11384336
    Abstract: FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: July 12, 2022
    Assignee: East Carolina University
    Inventors: Daniel Stephen Wilkinson, Mark D. Mannie
  • ALUMINUM BASED ADJUVANTS FOR TOLEROGENIC VACCINATION
    Publication number: 20210252137
    Abstract: The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 19, 2021
    Inventor: Mark D. Mannie
  • Aluminum based adjuvants for tolerogenic vaccination
    Patent number: 10940200
    Abstract: The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 9, 2021
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • COMPOSITIONS AND METHODS FOR IN VITRO CULTIVATION AND/OR EXPANSION OF REGULATORY T CELLS
    Publication number: 20190376031
    Abstract: FOXP3+ regulatory T cells (Tregs) can represent powerful adoptive immunotherapies for autoimmune diseases, metabolic diseases, and other chronic inflammatory diseases. The present invention is related to the ability to maintain and expand stable Treg lines and can provide insight into FOXP3+ Treg physiology and can enable feasible strategies of Treg-based immunotherapy.
    Type: Application
    Filed: December 7, 2017
    Publication date: December 12, 2019
    Inventors: Daniel Stephen WILKINSON, Mark D. MANNIE
  • Cytokines and neuroantigens for treatment of immune disorders
    Patent number: 10363306
    Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: July 30, 2019
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • Cytokine-based fusion proteins for treatment of immune disorders
    Patent number: 10273284
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: April 30, 2019
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • ALUMINUM BASED ADJUVANTS FOR TOLEROGENIC VACCINATION
    Publication number: 20180280498
    Abstract: The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided.
    Type: Application
    Filed: September 28, 2016
    Publication date: October 4, 2018
    Inventor: Mark D. Mannie
  • CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20170320933
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Application
    Filed: July 25, 2017
    Publication date: November 9, 2017
    Inventor: Mark D. Mannie
  • CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20170312358
    Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
    Type: Application
    Filed: May 10, 2017
    Publication date: November 2, 2017
    Inventor: Mark D. Mannie
  • Cytokine-based fusion proteins for treatment of immune disorders
    Patent number: 9745361
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: August 29, 2017
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • Cytokines and neuroantigens for treatment of immune disorders
    Patent number: 9669090
    Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: June 6, 2017
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20150125421
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventor: Mark D. Mannie
  • CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20150104414
    Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 16, 2015
    Inventor: Mark D. Mannie
  • Cytokine-based fusion proteins for treatment of multiple sclerosis
    Patent number: 8920808
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: December 30, 2014
    Assignee: East Carolina University
    Inventor: Mark D. Mannie
  • CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20120082644
    Abstract: The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
    Type: Application
    Filed: March 31, 2010
    Publication date: April 5, 2012
    Inventor: Mark D. Mannie
  • CYTOKINE-BASED FUSION PROTEINS FOR TREATMENT OF IMMUNE DISORDERS
    Publication number: 20100055070
    Abstract: The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided.
    Type: Application
    Filed: October 29, 2007
    Publication date: March 4, 2010
    Inventor: Mark D. Mannie