Abstract: The invention provides a compound of compound of formula (I): or a salt thereof, wherein R1, n, L, and X have any of the values described herein, as well as compositions and lipid nanoparticles comprising a compound of formula I, and their use for delivering therapeutic agents such as siRNA and mRNA.

Abstract: Various methods and devices are provided for allowing multiple surgical instruments to be inserted into sealing elements of a single surgical access device. The sealing elements can be movable along predefined pathways within the device to allow surgical instruments inserted through the sealing elements to be moved laterally, rotationally, angularly, and vertically relative to a central longitudinal axis of the device for ease of manipulation within a patient's body while maintaining insufflation.

Abstract: Disclosed herein are systems and methods for treating a magnesium or a magnesium alloy substrate. The system includes a cleaning composition having a pH greater than 8.5 or a solvent, and a pretreatment composition comprising an organophosphate compound and/or an organophosphonate compound. The method includes contacting a substrate surface with the cleaning composition or the solvent, and contacting the surface with the pretreatment composition. Also disclosed are substrates treated with one of the systems or methods. Also disclosed are magnesium or magnesium alloy substrates wherein, between the air/substrate interface and 500 nm below the air/substrate interface (a) oxygen and magnesium are present in a combined amount of at least 70 atomic %; (b) carbon is present in an amount of no more than 30 atomic %; and/or (c) fluoride is present in an amount of no more than 8 atomic %, wherein atomic % is measured by XPS depth profiling.

Abstract: Embodiments of the invention provide for persisting and retrieving search results based on a context of the search results and an application providing those results. For example, one embodiment of the present invention allows a user to access previous search result from a current page of a user interface, e.g., by clicking on an icon in the interface page. Additionally, these previous results can be made available without requiring the user to leave a current page in order to view the saved results. For example, the previous results can be indicated and accessible through an icon on the breadcrumb menu that, upon the user clicking of otherwise selecting the icon, causes the user interface to render the previous search results in a pop up dialog without leaving the current page.

Abstract: This invention is a wall support device for supporting a variety of commercially available flat panel television or video monitor wall mounts with related power and low voltage wiring access in a manner concealed from view.

Abstract: Embodiments of the invention provide for improved navigation in a user interface and access to search results. More specifically, embodiments of the present invention provide for persisting and retrieving search results based on a context of the search results and an application providing those results. For example, one embodiment of the present invention allows a user to access previous search result from a current page of a user interface, e.g., by clicking on an icon in the interface page. Additionally, these previous results can be made available without requiring the user to leave a current page in order to view the saved results. For example, the previous results can be indicated and accessible though an icon on the breadcrumb menu that, upon the user clicking of otherwise selecting the icon, causes the user interface to render the previous search results in a pop up dialog without leaving the current page.