Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the complement component C3 gene (C3). The invention also relates to methods of using such RNAi agents to inhibit expression of a C3 gene and to methods of preventing and treating a C3-associated disorder, e.g., cold agglutinin disease (CAD), warm autoimmune hemolytic anemia, and paroxysmal nocturnal hemoglobinuria (PNH), lupis nephritis (LN), bullous pemphigoid, pemphigus, e.g., pemphigus vulgaris (PV) and pemphigus foliaceus (PF), and C3 glomerulopathy.

Abstract: The disclosure relates to double-stranded ribonucleic acid (dsRNA) compositions targeting carbonic anhydrase 2 (CA2), and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of carbonic anhydrase 2.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CIDEB gene, as well as methods of inhibiting expression of CIDEB, and methods of treating subjects that would benefit from reduction in expression of CIDEB, such as subjects having a CIDEB-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CIDEB gene, as well as methods of inhibiting expression of CIDEB, and methods of treating subjects that would benefit from reduction in expression of CIDEB, such as subjects having a CIDEB-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: The present invention relates to RNAi agents, e.g., dsRNA agents, targeting the complement factor B (CFB) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a CFB gene and to methods of treating or preventing a CFB-associated disease in a subject.

Abstract: A computer-based method and system for tracking repairs of different types of components. The repair tracking system receives repair orders identifying components of customers that need repair. After a repair order is received, an engineer uses the repair tracking system to assign a repair plan to the repair order. When a repair technician receives a component or subcomponent of a repair order, the repair technician uses the repair tracking system to identify the steps that need to be performed next. After the repair of the component is complete, the repair technician uses the repair tracking system to indicate the completion and to determine where to send the component so that the next step in the repair plan can be performed.

Abstract: A computer-based method and system for tracking repairs of different types of components. The repair tracking system receives repair orders identifying components of customers that need repair. After a repair order is received, an engineer uses the repair tracking system to assign a repair plan to the repair order. When a repair technician receives a component or subcomponent of a repair order, the repair technician uses the repair tracking system to identify the steps that need to be performed next. After the repair of the component is complete, the repair technician uses the repair tracking system to indicate the completion and to determine where to send the component so that the next step in the repair plan can be performed.

Abstract: An apparatus and method for producing motor laminations from blanks uses a servo-controlled linear transport mechanism for transporting blanks a fixed stroke distance to a notching station wherein the notching station includes a stationary index spindle and movable punch head which adjusts for accommodating blanks of varying diameters. A lamination removal mechanism removes and transfers a notched lamination from the notching station to a lamination carrier by traveling a fixed stroke distance. Different diameter blanks are facilitated by adjusting grippers and the punch head while the stroke distances remain unchanged. The linear transport mechanism and the lamination removal mechanism move independently to transfer blanks and laminations at different times to improve blank throughput.