Abstract: An orthopaedic knee prosthesis includes a tibial insert and a femoral component configured to articulate on the tibial insert. The tibial insert includes a lateral articular surface and medial articular surface that is asymmetrically shaped relative to the lateral articular surface. The medial articular surface is shaped to reduce anterior translation of a medial condyle of the femoral component, while the lateral articular surface is shaped to allow a lateral condyle of the femoral component to pivot, relative to the medial articular surface, along an arcuate articular path. Additionally, one or both condyles of the femoral component may include a femoral articular surface having a curved femoral surface section defined by a continuously decreasing radius of curvature.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: The present disclosure describes aspects of Zener overvoltage protection (OVP) with a thermal trigger for an implant. In some aspects, an apparatus comprises a rectifier disposed in a rectification circuit and configured to rectify alternating current (AC) power received at the rectification circuit to direct current (DC) power. The apparatus also includes a Zener diode and thermistor. The Zener diode is disposed in the rectification circuit between the rectifier and an output terminal, and is configured to clamp the DC power at a predefined voltage. The clamped DC power output at the output terminal is usable by the implant. The thermistor and Zener diode are disposed in temperature-measuring proximity. This enables the thermistor to measure a temperature of the Zener diode, which correlates to voltage at the Zener diode due to clamping. When the measured temperature exceeds a threshold temperature indicative of an OVP condition, remedial OVP actions are initiated.

Abstract: An apparatus and method for lost power detection are described. In one implementation, an apparatus for wirelessly transferring power comprises a wireless power transmitter configured to wirelessly transmit power at a first power level sufficient to power or charge a chargeable device. The apparatus further comprises a controller configured to obtain a first power measurement of the first power level. The controller is further configured to determine a first adjusted power measurement of the first power measurement based on one or more tolerance values of the wireless power transmitter. The controller is further configured to determine a second adjusted power measurement of a second power measurement of a second power level received by the chargeable device based on one or more tolerance values of the chargeable device. The controller is further configured to determine if a power difference between the first and second adjusted power measurements exceeds a threshold value.

Abstract: An apparatus and method for lost power detection are described. In one implementation, an apparatus for wireless transferring power comprises a wireless power transmitter configured to wirelessly transmit power at a power level sufficient to power or charge a chargeable device. The apparatus further comprises a controller configured to determine a first and second power difference between a first and second power measurement and the second and a third power measurement of the power level provided by the wireless power transmitter at a first, second, and third sample time, respectively. The controller is further configured to determine a transmitter power difference between the first power difference and the second power difference. The controller is further configured to determine an absence or a presence of an object that affects consumption of power transmitted by the wireless power transmitter based at least on the transmitter power difference ?_T.

Abstract: An apparatus and method for lost power detection are described. In one implementation, an apparatus for wirelessly transferring power comprises a wireless power transmitter configured to wirelessly transmit power at a first power level sufficient to power or charge a chargeable device. The apparatus further comprises a controller configured to obtain a first power measurement of the first power level. The controller is further configured to determine a first adjusted power measurement of the first power measurement based on one or more tolerance values of the wireless power transmitter. The controller is further configured to determine a second adjusted power measurement of a second power measurement of a second power level received by the chargeable device based on one or more tolerance values of the chargeable device. The controller is further configured to determine if a power difference between the first and second adjusted power measurements exceeds a threshold value.

Abstract: An apparatus and method for lost power detection are described. In one implementation, an apparatus for wireless transferring power comprises a wireless power transmitter configured to wirelessly transmit power at a power level sufficient to power or charge a chargeable device. The apparatus further comprises a controller configured to determine a first and second power difference between a first and second power measurement and the second and a third power measurement of the power level provided by the wireless power transmitter at a first, second, and third sample time, respectively. The controller is further configured to determine a transmitter power difference between the first power difference and the second power difference. The controller is further configured to determine an absence or a presence of an object that affects consumption of power transmitted by the wireless power transmitter based at least on the transmitter power difference ?_T.

Abstract: A mobile device includes an adjustable impedance matching network coupled between a power amplifier and an antenna and has an adjustable impedance element. An impedance sensor is coupled between the power amplifier and adjustable impedance matching network. A processor is configured to a) calculate a corrected antenna load impedance based upon a sensed impedance at inputs of the impedance matching network and a current value of the adjustable impedance element, and b) determine a new value for the adjustable impedance element based upon the corrected antenna load impedance. The processor is also configured to c) set the adjustable impedance element to the new value, and d) sense a new impedance at the inputs and determine if the sensed new impedance is within a threshold value of the power amplifier impedance, and repeat steps a), b), and c) if the sensed new impedance is not within the threshold value.

Abstract: A composite substrate includes first and second substrate layers with a polyurethane foam layer there between. The foam layer preferably penetrates into the first and second substrate layers to form very strong bonds without the need for intervening adhesives. A component of the foam material formulation is natural oil. The resultant composite substrate thereby has excellent load-bearing properties. It can also be manufactured with lower cost capital equipment and a reduced impact on the environment relative to substrates using more conventional foam formulations and bonding processes.

Abstract: A mobile device includes an adjustable impedance matching network coupled between a power amplifier and an antenna and has an adjustable impedance element. An impedance sensor is coupled between the power amplifier and adjustable impedance matching network. A processor is configured to a) calculate a corrected antenna load impedance based upon a sensed impedance at inputs of the impedance matching network and a current value of the adjustable impedance element, and b) determine a new value for the adjustable impedance element based upon the corrected antenna load impedance. The processor is also configured to c) set the adjustable impedance element to the new value, and d) sense a new impedance at the inputs and determine if the sensed new impedance is within a threshold value of the power amplifier impedance, and repeat steps a), b), and c) if the sensed new impedance is not within the threshold value.

Abstract: The invention describes biological assays in which hydrogen peroxide is used as an oxidizing agent, or wherein hydrogen peroxide is used to oxidize a dye or other intermediate to generate a detectable species. The stability of the hydrogen peroxide in the presence of at least one other enzyme which decomposes hydrogen peroxide is enhanced by the addition of a suitable inhibitor for the enzyme and the inhibitor does not substantially inhibit enzymes used in the assay. When catalase is the enzyme to be inhibited, catalase inhibitors that can be used in the biological systems include hydroxylamine sulfate. The enzyme inhibitor can be incorporated in an integral analytic device.

Abstract: A mechanism used to control the vertical height as well as fore-aft position of a vehicle seat while presenting a minimum height profile when adjusted to minimum vertical elevation. The seat is connected to a pair of rails, one stationary and one reciprocable. A seat is affixed to an attachment bracket which is connected to the reciprocable rail by a vertical height adjuster comprising a vertically oriented screw jack which may be positioned to selectable heights by a motor. The fore-aft relationship of the rails may also be selectively adjusted by a motor driving a horizontally oriented screw jack. Both screw jacks incorporate a screw connected to a helical gear engaged to a worm gear. The worm gear is driven by a remote motor through a flexible drive cable. Both screw jacks present a structure which offers a minimum height profile when the seat is positioned at minimum vertical height.

Abstract: A mechanism used to control the vertical height as well as fore-aft position of a vehicle seat while presenting a minimum height profile when adjusted to minimum vertical elevation. The seat is connected to a pair of rails, one stationary and one reciprocable. A seat is affixed to an attachment bracket which is connected to the reciprocable rail by a vertical height adjuster comprising a vertically oriented screw jack which may be positioned to selectable heights by a motor. The fore-aft relationship of the rails may also be selectively adjusted by a motor driving a horizontally oriented screw jack. Both screw jacks incorporate a screw connected to a helical gear engaged to a worm gear. The worm gear is driven by a remote motor through a flexible drive cable. Both screw jacks present a structure which offers a minimum height profile when the seat is positioned at minimum vertical height.

Abstract: A mechanism used to control the vertical height as well as fore-aft position of a vehicle seat while presenting a minimum height profile when adjusted to minimum vertical elevation. The seat is connected to a pair of rails, one stationary and one reciprocable. A seat is affixed to an attachment bracket which is connected to the reciprocable rail by a vertical height adjuster comprising a vertically oriented screw jack which may be positioned to selectable heights by a motor. The fore-aft relationship of the rails may also be selectively adjusted by a motor driving a horizontally oriented screw jack. Both screw jacks incorporate a screw connected to a helical gear engaged to a worm gear. The worm gear is driven by a remote motor through a flexible drive cable. Both screw jacks present a structure which offers a minimum height profile when the seat is positioned at minimum vertical height.

Abstract: A mechanism used to control the vertical height as well as fore-aft position of a vehicle seat while presenting a minimum height profile when adjusted to minimum vertical elevation. The seat is connected to a pair of rails, one stationary and one reciprocable. A seat is affixed to an attachment bracket which is connected to the reciprocable rail by a vertical height adjuster comprising a vertically oriented screw jack which may be positioned to selectable heights by a motor. The fore-aft relationship of the rails may also be selectively adjusted by a motor driving a horizontally oriented screw jack. Both screw jacks incorporate a screw connected to a helical gear engaged to a worm gear. The worm gear is driven by a remote motor through a flexible drive cable. Both screw jacks present a structure which offers a minimum height profile when the seat is positioned at minimum vertical height.

Abstract: An electronically controlled lighting panelboard characterized by a power line panelboard having a plurality of remotely controlled circuit breakers for opening and closing circuits to corresponding loads. Each circuit breaker is interconnected to an interface which in turn is connected by a multi-conductor cable to an electronic controller or computer.

Abstract: A robot laser work cell combines a plurality of systems which include an orthogonal axis manipulator system, a laser beam delivery system, a safety enclosure system, a coolant chiller for the laser beam delivery system, an air filtration and drying system in communication with the laser beam delivery system, an exhaust system for removing toxic fumes from the area proximate the output of the laser beam delivery system and a variety of precision table and other fixturing means which can be used in combination to function as the work cell of this invention. In an alternative embodiment, a laser package is mounted by a modular wrist onto the Z-axis of the orthogonal axis manipulator and the laser beam delivery system.

Abstract: A patient signalling system comprising a touch sensitive capacitive transducer adapted to be conveniently and comfortably placed with a patient afflicted with an illness or paralysis rendering him incapable of producing any significant manual force or dexterity, a flexible electrical cable of appreciable length connected at one end to the transducer, and a circuit located remote from the patient and connected to the other end of the cable for converting a change in capacitance of the transducer when touched by the patient into an electrical signal for causing operation of an appliance such as a signalling or communication device connected to the circuit. The circuit includes an input stage in the form of a high input impedance semiconductor device, a direct coupled a.c. amplifier, a resistive coupled a.c. amplifier, and a d.c. semiconductor switch. The system can include provision for patient electrical isolation and low battery voltage indication.