Patents by Inventor Mark DARIS

Mark DARIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-terminal anti-sclerostin antibody variants
    Patent number: 11858983
    Abstract: The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: January 2, 2024
    Assignee: AMGEN INC.
    Inventors: Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
  • C-TERMINAL ANTIBODY VARIANTS
    Publication number: 20230015713
    Abstract: The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
    Type: Application
    Filed: September 23, 2022
    Publication date: January 19, 2023
    Inventors: Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
  • ENGINEERED T CELL RECEPTORS AND USES THEREOF
    Publication number: 20220389075
    Abstract: Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.
    Type: Application
    Filed: November 10, 2020
    Publication date: December 8, 2022
    Inventors: Julyun OH, Chang Yi, Dora Toledo Warshaviak, Jee Young Mock, Mark Daris, Agnes Hamburger, James Johnston, Carl Alexander Kamb
  • ENGINEERING CHARGE PAIR MUTATIONS FOR PAIRING OF HETERO-IgG MOLECULES
    Publication number: 20220389119
    Abstract: The present invention relates to heterodimers comprising antibody CH3 domains and mutations useful for the facilitation of the formation of heterodimers. Methods of optimizing purification of the heterodimers at certain pHs in also disclosed.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 8, 2022
    Inventors: Bram ESTES, Fernando GARCES, Zhulun WANG, Mark DARIS
  • C-terminal antibody variants
    Patent number: 11466079
    Abstract: The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: October 11, 2022
    Assignee: AMGEN INC.
    Inventors: Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
  • C-TERMINAL ANTIBODY VARIANTS
    Publication number: 20210079082
    Abstract: The invention generally relates to anti-sclerostin antibodies having C-terminal modifications, and compositions comprising such antibodies.
    Type: Application
    Filed: March 29, 2019
    Publication date: March 18, 2021
    Inventors: Zhe Huang, Jennitte LeAnn Stevens, Greg Flynn, Szilan Fodor, Mark Daris
  • Promoter and regulatory elements for improved expression of heterologous genes in host cells
    Patent number: 10202616
    Abstract: Disclosed are a recombinant expression vector and a host cell that contains the vector.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: February 12, 2019
    Assignee: AMGEN INC.
    Inventors: Mark Daris, Jennitte LeAnn Stevens, Chi-Ming Kevin Li, Huanying Ge
  • Promoter and Regulatory Elements for Improved Expression of Heterologous Genes in Host Cells
    Publication number: 20170253889
    Abstract: Disclosed are a recombinant expression vector and a host cell that contains the vector.
    Type: Application
    Filed: October 14, 2015
    Publication date: September 7, 2017
    Applicant: AMGEN INC.
    Inventors: Mark DARIS, Jennitte LeAnn STEVENS, Chi-Ming Kevin LI, Huanying GE