Patents by Inventor Mark David Vincent

Mark David Vincent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING CANCER AND/OR ENHANCING SENSITIVITY TO CANCER TREATMENT BY INCREASING TUMOR MUTATION BURDEN OR TUMOR INDELS
    Publication number: 20250179501
    Abstract: Methods of treating cancer or enhancing sensitivity to cancer therapies including immunotherapies by increasing tumor mutation burden. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 or PMS2 are provided. The therapeutics can be used alone, in tandem or in combination with other cancer therapies, in particular with immunotherapies. Also provided are antisense therapeutics targeting DNA polymerase proofreading and/or mismatch repair enzymes.
    Type: Application
    Filed: November 14, 2024
    Publication date: June 5, 2025
    Inventor: Mark David Vincent
  • Methods of treating cancer and/or enhancing sensitivity to cancer treatment by increasing tumor mutation burden or tumor indels
    Patent number: 12234459
    Abstract: Methods of treating cancer or enhancing sensitivity to cancer therapies, including immunotherapies by increasing tumor mutation burden, are provided. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 or PMS2. The therapeutics can be used alone, in tandem or in combination with other cancer therapies, in particular with immunotherapies. Also provided are antisense therapeutics targeting DNA polymerase proofreading and/or mismatch repair enzymes.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: February 25, 2025
    Inventor: Mark David Vincent
  • RAD51 BINDING INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20240083883
    Abstract: The present invention provides RAD51 inhibitors having the structural formula (I): or a pharmaceutically acceptable salt or solvate thereof. Also provided are methods of treating or preventing cancer comprising administration of the compounds of the present invention, as well as uses of the compounds to induce a synergistic effect with known chemotherapeutic.
    Type: Application
    Filed: December 31, 2021
    Publication date: March 14, 2024
    Inventors: Mark David VINCENT, Peter John Ferguson, Donald James Koropatnick
  • METHODS OF TREATING CANCER AND/OR ENHANCING SENSITIVITY TO CANCER TREATMENT BY INCREASING TUMOR MUTATION BURDEN OR TUMOR INDELS
    Publication number: 20210198675
    Abstract: Methods of treating cancer or enhancing sensitivity to cancer therapies, including immunotherapies by increasing tumor mutation burden, are provided. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 or PMS2. The therapeutics can be used alone, in tandem or in combination with other cancer therapies, in particular with immunotherapies. Also provided are antisense therapeutics targeting DNA polymerase proofreading and/or mismatch repair enzymes.
    Type: Application
    Filed: October 23, 2018
    Publication date: July 1, 2021
    Inventor: Mark David Vincent