Abstract: A virtual environment may be provided to facilitate education and knowledge gathering by users. The users may include children, youth, and/or other users. The users may be enabled to form connections between themselves and/or experts, and to communicate between themselves and/or with experts. Users may be provided with a different interface than experts.

Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target nsk assessment score, accesses an input attribute vector for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on the statistics computed from the particular cluster. The first point corresponds to the current risk assessment score and the second point corresponds to the target risk assessment score. The entity assessment server computes an attribute-change vector so that a path defined by the attribute-change vector complies with the requirement and generates the recommendation from the attribute-change vector.

Abstract: A cast piston for an internal combustion engine is made of an iron-based material and has windows in at least one side wall carrying a piston pin boss. The windows are asymmetric relative to one another on the side of the skirt walls.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target nsk assessment score, accesses an input attribute veclor for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on tire statistics computed from tltc particular cluster The first point corresponds to tire current risk assessment score and the second point corresponds to the target nsk assessment score. The entity assessment server computes an attribute-changc vecior so that a path defined by the attribute-change vector complies with the requirement and generates tlic recommendation from the attribute-changc vector.

Abstract: Disclosed are therapeutic payloads comprising p97 fragments coupled with active agents having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, to facilitate delivery of therapeutic or diagnostic agents across the BBB. The therapeutic payloads can be effective in the treatment of conditions which involve the lymphatic system of the subject, and may also present a disease state in the brain of the subject. Methods of treating diseases involving the lymphatic system and pharmaceutical compositions are also disclosed.

Abstract: A containment berm formed of a flexible, substantially impermeable polymer material defining a ground section with a plurality of sidewalls extending upward from the ground section. A plurality of hinges are positioned on an interior of the containment berm, with the hinges having first and second aims rotating on a pin, the first arm engaging a first sleeve on one of either the ground section or a sidewall, and the second arm engaging a second sleeve on the other of the ground section or the sidewall. The second sleeve is configured to allow the hinge to slide far enough away from the first sleeve to allow the first arm to disengage from the first sleeve.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: A cast piston for an internal combustion engine is made of an iron-based material and has windows in at least one side wall carrying a piston pin boss. The windows are asymmetric relative to one another on the side of the skirt walls.

Abstract: Disclosed are therapeutic payloads comprising p97 fragments coupled with active agents having blood-brain barrier (BBB) transport activity, including variants and combinations thereof, to facilitate delivery of therapeutic or diagnostic agents across the BBB. The therapeutic payloads can be effective in the treatment of Gaucher disease. Methods of treating Gaucher disease and pharmaceutical compositions are also disclosed.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: Urinal mat having a flexible, gridded, porous top layer, a disposable, highly liquid-absorbent pad or pad-type middle layer, and an effectively waterproof bottom layer, heavy enough to stay in place without adhesives, and thin enough, with tapered sides, to avoid being a tripping hazard. The top layer fits within a recess in the bottom layer and interlockingly attaches to the bottom layer, with the pad in-between. The interlocking attachment is accomplished by the fitting of horizontal protrusions on the perimeter of the top layer fitting into corresponding peripheral recesses in the bottom layer, and provides a smooth level horizontal top surface of the mat.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.