Patents by Inventor Mark Deem

Mark Deem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11406592
    Abstract: An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: August 9, 2022
    Assignee: Mati Therapeutics Inc.
    Inventors: Eugene de Juan, Jr., Cary Reich, Stephen Boyd, Hanson S. Gifford, III, Mark Deem
  • Publication number: 20220183964
    Abstract: The present technology relates to depots for the treatment of select symptoms via sustained, controlled release of a therapeutic agent. In some embodiments, the depot may comprise a therapeutic region comprising the therapeutic agent, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for an extended period of time.
    Type: Application
    Filed: April 11, 2020
    Publication date: June 16, 2022
    Inventors: Karun D. Naga, Hanson S. Gifford, III, Mark Deem, Stephen W. Boyd, Nassireddin Mokarram-Dorri, Koon Kiat Teu, Daniel Boon Lim Seet, Wei Li Lee, Honglei Wang
  • Publication number: 20220183963
    Abstract: The present technology relates to implantable depots for the local, sustained, controlled release of a therapeutic agent to treat cancer. An implantable depot may comprise a biodegradable polymer mixed with a locally-acting therapeutic agent configured to treat cancer. The depot may be configured to be implanted within a patient proximate cancerous tissue and, while implanted, provide sustained exposure of the therapeutic agent at the treatment site for a period of time that is no less than 5 days.
    Type: Application
    Filed: April 11, 2020
    Publication date: June 16, 2022
    Inventors: Steven Kim, Karun D. Naga, Hanson S. Gifford, III, James Su, Nassireddin Mokarram-Dorri, Mark Deem, Stephen W. Boyd, Koon Kiat Teu, Daniel Boon Lim Seet, Wei Li Lee, Honglei Wang, Edward D. Gifford
  • Patent number: 11272913
    Abstract: A method of treating a patient's joint having opposing joint surfaces includes providing an elongate member having a proximal end, a distal end and an expandable member near the distal end. The expandable member is positioned in the joint between the joint surfaces and expanded so as to separate the joint surfaces away from one another into a distracted position. The joint is manipulated while in the distracted position so that the joint is distracted and in flexion. A diagnostic or therapeutic procedure is then performed on the joint while maintaining the joint in the flexed and distracted position.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: March 15, 2022
    Assignee: Stryker Corporation
    Inventors: David Boudreault, Vivek Shenoy, Hanson S. Gifford, Mark Deem, Michael Hendricksen, Doug Sutton
  • Patent number: 11272925
    Abstract: A method for impacting a suture anchor into bone comprises providing an implantable suture anchor and providing an impactor device for impacting the suture anchor into the bone. The suture anchor is coupled to a distal portion of the impactor device. Positioning the suture anchor engages the anchor with the bone at an implantation site, and powering the impactor device impacts the suture anchor thereby implanting the suture anchor into the bone. The frequency of impaction is less than 20 KHz. The impactor device is then decoupled from the suture anchor, and the impactor device may be removed from the implantation site.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: March 15, 2022
    Assignee: THE FOUNDRY, LLC
    Inventors: Darin C. Gittings, Mark Deem, Hanson S. Gifford, Doug Sutton, Vivek Shenoy
  • Publication number: 20220008194
    Abstract: Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system for delivering a prosthetic device into a heart of a patient includes an elongated catheter body and a delivery capsule. The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.
    Type: Application
    Filed: September 27, 2021
    Publication date: January 13, 2022
    Inventors: Mark Deem, Hanson Gifford, III, John Morriss, Matt McLean, Michael Luna
  • Publication number: 20210353532
    Abstract: The present technology relates to depot assemblies for the controlled, sustained release of a therapeutic agent. The assembly can include a depot having a therapeutic region comprising an analgesic, and a control region comprising a bioresorbable polymer and a releasing agent mixed with the polymer. The releasing agent may be configured to dissolve when the depot is placed in vivo to form diffusion openings in the control region. The depot may be configured to be implanted at a treatment site in vivo and, while implanted, release the therapeutic agent at the treatment site for no less than 3 days. The assembly further includes a fixation portion coupled to the depot and configured to facilitate attachment of the depot assembly to tissue at or adjacent to the treatment site.
    Type: Application
    Filed: August 27, 2019
    Publication date: November 18, 2021
    Inventors: Karun D. Naga, Hanson S. Gifford, III, Jackie Joe Hancock, Stephen W. Boyd, John Morriss, Patrick H. Ruane, Michael Feldstein, Darren Doud, Mark Deem, Koon Kiat Teu, Daniel Boon Lim Seet, Wei Li Lee, Honglei Wang
  • Publication number: 20210338221
    Abstract: Devices and methods are disclosed herein for accessing the hip joint. A first device can be securely attached to the capsule of a joint. The first device can tent the capsule to increase the volume of the peripheral compartment. A second device can be biased against the first device to pierce the tented capsule and create a portal. Devices and methods are also disclosed herein for distending the capsule of a joint. A distention device may access a portal established within the capsule. The distention device can expand the capsule by applying an expansive force within the peripheral compartment. The distention device can maintain distention of the peripheral compartment while other devices access the joint.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 4, 2021
    Inventors: Thomas Weisel, Geoff Willis, James Flom, Hanson S. Gifford, Mark Deem, Darin Gittings, Lynette Ross, Dwayne Dupree, Matthew Frushell
  • Patent number: 11129714
    Abstract: Systems, apparatuses, and methods for treating native heart valves are disclosed herein. A system for delivering a prosthetic device into a heart of a patient includes an elongated catheter body and a delivery capsule. The delivery capsule can be hydraulically driven to deploy at least a portion of a prosthetic heart valve device. The delivery capsule can release the prosthetic heart valve device at a desired treatment site in a patient.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 28, 2021
    Assignee: Twelve, Inc.
    Inventors: Mark Deem, Hanson Gifford, III, John Morriss, Matt McLean, Michael Luna
  • Publication number: 20210212941
    Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
    Type: Application
    Filed: December 24, 2020
    Publication date: July 15, 2021
    Applicant: Mati Therapeutics, Inc.
    Inventors: Eugene de Juan, Stephen Boyd, Cary J. Reich, Alan R. Rapacki, Hanson S. Gifford, Mark Deem
  • Publication number: 20210196455
    Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.
    Type: Application
    Filed: March 15, 2021
    Publication date: July 1, 2021
    Inventors: John Morriss, Hanson Gifford, III, James I. Fann, Jean-Pierre Dueri, Matt McLean, Darin Gittings, Michael Luna, Mark Deem, Douglas Sutton, Jeffry J. Grainger
  • Patent number: 11000267
    Abstract: Various devices, systems and methods for knotless suturing of tissue are disclosed. These devices allow sutures to be anchored to bone, and more specifically provide a suture anchor which eliminates the need for knotting the suture. Thus, damaged tissue may be re-attached to a substrate tissue. The anchors have a minimum of moving parts may be suited to being a single molded polymer construction. The anchors will find particular utility in hip and shoulder arthroscopy, e.g. labral re-attachment and similar procedures.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 11, 2021
    Assignee: The Foundry, LLC
    Inventors: Michael Hendricksen, Mark Hirotsuka, Mark Deem, Jeffry J. Grainger, Darin Gittings
  • Patent number: 10945835
    Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: March 16, 2021
    Assignee: TWELVE, INC.
    Inventors: John Morriss, Hanson Gifford, III, James I. Fann, Jean-Pierre Dueri, Matt McLean, Darin Gittings, Michael Luna, Mark Deem, Douglas Sutton, Jeffry J. Grainger
  • Patent number: 10898237
    Abstract: Pathology of the human spine can arise from excessive and/or uneven loading of regions within the spinal vertebrae and the intervertebral disc. Methods and apparatus are disclosed that enable displacement of soft tissue around the spine in a less invasive manner, thereby altering the mechanical load distribution within the spine to achieve a therapeutic effect.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: January 26, 2021
    Assignee: The Foundry, LLC
    Inventors: Vivek Shenoy, Hanson S. Gifford, III, Mark Deem
  • Patent number: 10874606
    Abstract: An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: December 29, 2020
    Assignee: Mati Therapeutics Inc.
    Inventors: Eugene de Juan, Jr., Stephen Boyd, Cary Reich, Alan Rapacki, Hanson S. Gifford, Mark Deem
  • Patent number: 10850091
    Abstract: Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: December 1, 2020
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand
  • Publication number: 20200368398
    Abstract: The devices, systems, and methods disclosed herein may be directed to a delivery system including a therapeutic member configured for endoluminal placement via the delivery system into the esophagus of the patient, wherein the therapeutic member comprises a treatment portion comprising a film for controlled release of a chemotherapeutic agent. The film may comprise a control region, a therapeutic region, and a substantially impermeable base region. The film is configured to release the chemotherapeutic agent in a direction away from the substantially impermeable base region. The delivery system is configured to enable a treatment provider to position the treatment portion of the therapeutic member proximate to a treatment site associated with the esophagus of the patient, and the therapeutic member is configured to administer a therapeutically effective dose to the treatment site for a sustained period following endoluminal placement of the therapeutic member.
    Type: Application
    Filed: January 8, 2019
    Publication date: November 26, 2020
    Inventors: Karun D. Naga, Stephen W. Boyd, Hanson S. Gifford, III, Mark Deem, John Morriss, Martin Mayse, Honglei Wang, Jingnan Luo, Daniel Boon Lim Seet, Koon Kiat Teu, Wei Li Lee
  • Publication number: 20200253583
    Abstract: An implantable ultrasonic vascular sensor for implantation at a fixed location within a vessel, comprising at least one ultrasound transducer, a transducer drive circuit, and means for wirelessly transmitting ultrasound data from the at least one ultrasound transducer.
    Type: Application
    Filed: May 31, 2018
    Publication date: August 13, 2020
    Inventors: Axel Brisken, Jessi Johnson, Douglas S. Sutton, Hanson S. Gifford, III, Mark Deem, Fiachra Sweeney
  • Patent number: 10702380
    Abstract: Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include a valve support having an upstream end and a downstream end extending around a longitudinal axis and having a cross-sectional shape. The valve support can have an outer surface and an inner surface, wherein the inner surface is configured to support a prosthetic valve. The device can also include an expandable retainer coupled to the upstream end of the valve support. The retainer can be configured to engage tissue on or near the annulus. In some embodiments, the valve support is mechanically isolated from the retainer such that the cross-sectional shape of the valve support remains sufficiently stable when the retainer is deformed in a non-circular shape by engagement with the tissue.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: July 7, 2020
    Assignee: Twelve, Inc.
    Inventors: John Morriss, Hanson Gifford, III, James L. Fann, Jean-Pierre Dueri, Darrin Gittings, Michael Luna, Mark Deem, Douglas Sutton
  • Patent number: 10695094
    Abstract: Pathology of the human knee can arise from excessive and/or uneven loading of regions within the joint. Methods and apparatus are disclosed that enable displacement of soft tissue around the knee, without displacing or severing bone thereby altering the mechanical load distribution within the joint in a less invasive manner than previous techniques.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 30, 2020
    Assignee: The Foundry, LLC
    Inventors: Vivek Shenoy, Hanson S. Gifford, III, Mark Deem