Patents by Inventor Mark Demma

Mark Demma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • p53 modulators
    Patent number: 7790474
    Abstract: The present invention provides compositions as well as methods for identifying compositions useful for treating or preventing cancer.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: September 7, 2010
    Assignee: Schering Corporation
    Inventors: Bimalendu Dasmahapatra, Bernard R. Neustadt, Mark Demma, Alan K. Mallams, Henry A. Vaccaro, Jonathan A. Pachter
  • DEVELOPMENT OF A NOVEL ASSAY FOR MGMT (METHYL GUANINE METHYL TRANSFERASE)
    Publication number: 20070264672
    Abstract: The present invention provides improved methods for assessing the level of MGMT activity in a variety of biological preparations. MGMT, a DNA repair enzyme, can reduce the chemotherapeutic efficacy of alkylating agents by repairing the damage that alkylating agents do to tumor cell DNA. The methods of the present invention can be used, inter alia, to measure MGMT levels and to thereby predict the clinical response to alkylating agents. The present invention includes three preferred assays for assessment of MGMT activity: (1) the immunoassay technique, (2) the labeled O6—BG technique, and (3) the fluorescence polarization technique. Kits useful for the performance of such assays are also provided.
    Type: Application
    Filed: May 7, 2007
    Publication date: November 15, 2007
    Inventors: Bimalendu Dasmahapatra, Mark Demma
  • Quinazoline derivatives useful in cancer treatment
    Publication number: 20070032502
    Abstract: The present invention provides compounds of Formula I (wherein X, m, R1, R2, R3, and R4 are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
    Type: Application
    Filed: July 13, 2006
    Publication date: February 8, 2007
    Inventors: Alan Mallams, Bimalendu Dasmahapatra, Bernard Neustadt, Mark Demma, Henry Vaccaro
  • Quinazoline derivatives useful in cancer treatment
    Publication number: 20070015774
    Abstract: The present invention provides compounds of Formula I (wherein R1, R2, R3, L, and X are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
    Type: Application
    Filed: July 13, 2006
    Publication date: January 18, 2007
    Inventors: Alan Mallams, Bimalendu Dasmahapatra, Bernard Neustadt, Mark Demma, Henry Vaccaro