Abstract: The present invention relates to therapeutic agents with reduced toxicity comprising a serum albumin binding peptide (SABP), a targeting agent and a cytotoxic agent. The present invention also relates to methods for reducing the toxicity of therapeutic agents and methods of treatment using the therapeutic agents with reduced toxicity.

Abstract: Peptide ligands having affinity for serum albumin are useful for tumor targeting. Conjugate molecules comprising a serum albumin binding peptide fused to a biologically active molecule demonstrate modified pharmacokinetic properties as compared with the biologically active molecule alone, including tissue (e.g., tumor) uptake, infiltration, and diffusion.

Abstract: A vent system for an infusion drip chamber is provided according to the invention. The vent system includes an automatic air eliminator communicating with an interior and an exterior of the infusion drip chamber. The automatic air eliminator is capable of automatically venting air from the infusion drip chamber in a substantially continuous manner. The vent system further includes a mechanical air eliminator communicating with the interior and the exterior of the infusion drip chamber. The manual air eliminator is capable of mechanically venting air from the infusion drip chamber at discrete time intervals.

Abstract: The distribution of traffic flows in a load-sharing redundancy group that includes a first gateway device and a second gateway device includes assigning a first set of forwarding addresses to the first gateway device and a second set of forwarding addresses to the second gateway device. The redundancy group distributes forwarding addresses to hosts which in turn use the distributed forwarding addresses to send packets to the redundancy group. The traffic flow for each of the assigned forwarding addresses is measured and may be compared to a target traffic flow. The traffic flow is adjusted to close in on the target traffic flow. Adjustment of the traffic flow can be accomplished either by changing the existing measured traffic flow by re-assigning a forwarding address originally assigned to one gateway device to a different gateway device or by altering future distribution of forwarding addresses so that additional traffic is sent to one or more forwarding addresses having lower measured traffic.

Abstract: A vent system for an infusion drip chamber is provided according to the invention. The vent system includes an automatic air eliminator communicating with an interior and an exterior of the infusion drip chamber. The automatic air eliminator is capable of automatically venting air from the infusion drip chamber in a substantially continuous manner. The vent system further includes a mechanical air eliminator communicating with the interior and the exterior of the infusion drip chamber. The manual air eliminator is capable of mechanically venting air from the infusion drip chamber at discrete time intervals.

Abstract: A new directory service is established for a peer router receiving a data packet from an end station on a local area network connected to a port of the peer router, the peer router hereinafter being referred to as the source router. The data packet is addressed to a destination address. The source router determines that the data packet is to be encapsulated as an encapsulated packet, and the encapsulated packet routed by a peer-to-peer protocol to a destination router. The destination router then transmits the packet onto a local area network to the destination address. The source router locates the proper peer destination router by use of a database. The database is maintained on a server, where the database has entries for destination address, and an entry for a particular destination address gives the address of a peer router capable of routing a packet to that particular destination address.

Abstract: A complete management system for specialized routers such as, for example, DLSw routers is provided. The management system uses a server to maintain a DLSw Directory, for example an LDAP directory. Whenever a DLSw router is booted, the DLSw router sends a registration message to the Server giving the network address of the DLSw router. The Server then maintains a directory of all DLSw routers in the network (the DLSw Directory). The information maintained in the DLSw Directory has the network address of each DLSw router, as received when the router is booted up. Also, at later times, the DLSw router sends a message to the DLSw Directory giving further information about the DLSw router. The further information comprises data such as: the types of encapsulation being received and routed by the router, etc.

Abstract: A vent system for an infusion drip chamber is provided according to the invention. The vent system includes an automatic air eliminator communicating with an interior and an exterior of the infusion drip chamber. The automatic air eliminator is capable of automatically venting air from the infusion drip chamber in a substantially continuous manner. The vent system further includes a mechanical air eliminator communicating with the interior and the exterior of the infusion drip chamber. The manual air eliminator is capable of mechanically venting air from the infusion drip chamber at discrete time intervals.

Abstract: A system and method of discriminating faults in an error signal, such as that from a control input sensor, comprises a system for and method of determining allowable limits of an error signal versus time, passing the error signal through a low-pass filter, comparing output of the low-pass filter with a threshold and outputting a fault condition when the output of the low-pass filter exceeds the threshold. The time constant or constants of the low-pass filter and the threshold are selected so that a fault condition is detected when the error signal approaches the allowable limits before exceeding them.

Abstract: The present invention relates to a carpet cleaning composition comprising about 50% by weight to about 98% by weight water; about 0.05% by weight to about 2% wt-% of at least one emulsifier that is an acrylic copolymer; about 1% by weight to about 50% by weight of at least one solvent; 0% to about 1% by weight of at least one surfactant; and at least one alkaline compound for buffering. The resultant cleaning composition has an adjusted pH from about 4 to about 10.

Abstract: A diagnostic system for electric motors, such as those used in automotive applications. The system comprises a controller for supplying a desired command current to said electric motor, a sensor for measuring the rotational speed of the motor, a sensor for measuring the actual current supplied to the motor by the controller, a diagnostic control unit adapted to receive the measured rotational speed, measured supplied voltage, and a command current level value as inputs. The diagnostic control unit further comprises circuitry to calculate an estimated actual current drawn by the motor and to signal an error condition if the estimated actual current is not within a calculated valid range.

Abstract: A pulsed measurement technique for calorimetric sensors provides a short current pulse through catalyzed and inert sensor elements to minimize self heating while providing for sensor resistance measurement, so that a determination of the level of catalytic activity at the surface of the catalyzed element may be made for sensing the concentration of combustible elements of automotive internal combustion engine exhaust gas. Exhaust gas temperature measurement is provided by monitoring the inert element resistance. Exhaust gas flow rate measurement is provided by heating the inert element for a short heating period, and then removing the heat source while monitoring the time rate of return to the known initial inert element temperature.

Abstract: The present invention relates to a novel nut paste having a particular monomodal particle size distribution and to monomodal full-fat nut butters and monomodal reduced fat nut spreads which contain the novel nut paste and which, as a result, have superior fluidity, texture and flavor. These nut butters and nut spreads typically comprise from about 50% to 100% of a nut paste. The Casson plastic viscosity of the nut paste is less than about 15 poise and the fat content of the nut paste is at least about 45%. The nut butters have a fat content ranging from about 25% to about 80%. The final nut butters and nut spread products of the present invention have a Casson plastic viscosity of less than about 17 poise and a yield value below about 300 dynes per square centimeter.

Abstract: A novel class of 2-(1(2H)-phthalazinone)sulfenamides is described which sulfenamides are useful as inhibitors of premature vulcanization of rubber.