Abstract: Provided herein are compositions comprising ruboxistaurin free base and its salts thereof and methods of use for treating conditions of the skin.

Abstract: Disclosed herein are compositions and methods of treating one or more symptom(s) related to a hyperpigmentation disorder.

Abstract: Provided herein is a composition including a compound having the structure: a pharmaceutically acceptable salt(s) thereof, and one or more excipients selected from (a)-(g): a) C2-6 alcohol; b) an organic solvent and/or a penetration enhancer; c) an antioxidant; d) a preservative; e) water; f) a pH adjuster; and g) a gelling agent, wherein C2-6 alcohol, the organic solvent and/or a penetration enhancer, the antioxidant, the preservative, water, the pH adjuster, and the gelling agent are defined and described herein. Methods of treating a skin disease, condition or disorder, in particular seborrheic keratosis, with the compositions are also provided herein.

Abstract: Provided herein are compositions comprising ruboxistaurin free base and its salts thereof and methods of use for treating conditions of the skin.

Abstract: Disclosed herein are compositions and methods of treating one or more symptom(s) related to a hyperpigmentation disorder.

Abstract: The present disclosure provides methods of treating epidermolysis bullosa, and/or preventing, preventing the progression of, or delaying the onset of one or more symptom associated with scarring, e.g., of blisters, in subjects with epidermolysis bullosa through chronic systemic administration of collagen 7.

Abstract: Disclosed herein are compositions and methods of treating one or more symptom(s) related to a hyperpigmentation disorder.

Abstract: Disclosed are methods of making collagen 7, or functional fragments thereof, as well as collagen 7, and functional fragments thereof produced by such methods, nucleic acids encoding collagen 7, and functional fragments thereof, as well as vectors and host cells comprising such nucleic acids.

Abstract: The present disclosure provides methods of treating epidermolysis bullosa, and/or preventing, preventing the progression of, or delaying the onset of one or more symptom associated with scarring, e.g., of blisters, in subjects with epidermolysis bullosa through chronic systemic administration of collagen 7.

Abstract: The invention provides methods and compositions for trace element, particularly heavy metal phytoremediation, including plants which are genetically engineered to overexpress a sulfate assimilation pathway enzyme gene and thereby provide enhanced trace element accumulation. In various embodiments, the plants comprise the gene operably linked to a heterologous promoter, the plant is a member of the Brassicaceae family. In general, the methods comprise the steps of growing such plants in a medium such as soil or water comprising a trace element, under conditions wherein the gene is overexpressed, whereby the plant provides enhanced accumulation of the trace element, whereby the trace element content of the medium is decreased.