Abstract: Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.

Abstract: By providing a hand holdable, reusable, holding system which enables users to insert any small diameter, shaft supporting pyrotechnic device, such as a sparkler, into an aperture and be assured that the shaft of the pyrotechnic device is securely locked to the holding system for protecting the individual from harm, an easily constructed, easily used holding system is attained which is capable of enabling any elongated, small diameter wire or shaft to be quickly inserted into the holding system and securely lockingly engaged therewith. In this way, the pyrotechnic material which is adhered to the upper portion of the elongated shaft or wire is easily held by the user in a safe and effective manner.