Patents by Inventor Mark Distefano

Mark Distefano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20240327804
    Abstract: Certain embodiments of the invention provide conjugates, chemically self-assembled nanoring (CSAN), and cell modified with CSAN as described herein. Certain embodiments of the invention provide a method for cell-based drug delivery. Certain embodiments of the invention provide a method of transferring a cargo from a sender cell to a receiver cell as described herein.
    Type: Application
    Filed: March 1, 2024
    Publication date: October 3, 2024
    Applicant: Regents of the University of Minnesota
    Inventors: Carston R. Wagner, Yiao Wang, Mark Distefano
  • Triorthogonal reagents for dual protein conjugation
    Patent number: 9878045
    Abstract: The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot procedure. This approach relies on the selective tagging of proteins containing an appended farnesyltransferase or geranylgeranyltransferase I substrate sequence. The incorporation of a bifunctional ethynyl-hydroxybenzaldehyde into the farnesyl or geranylgeranyl group facilitates the facile labeling of proteins with two different moieties.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: January 30, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Mark Distefano, Mohammad Rashidian
  • TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION
    Publication number: 20160271261
    Abstract: The present invention relates to triorthogonal reagents useful for site-specifically modifying a protein with two orthogonal groups that can be subsequently functionalized in a single one-pot procedure. This approach relies on the selective tagging of proteins containing an appended farnesyltransferase or geranylgeranyltransferase I substrate sequence. The incorporation of a bifunctional ethynyl-hydroxybenzaldehyde into the farnesyl or geranylgeranyl group facilitates the facile labeling of proteins with two different moieties.
    Type: Application
    Filed: October 15, 2014
    Publication date: September 22, 2016
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mark Distefano, Mohammad Rashidian