Abstract: The disclosure provides engineered interleukin 18 (TL-18) polypeptides with reduced binding to IL-18 binding protein (IL-18BP) and maintained or improved binding to one or both of IL-18 Receptor alpha (IL-18R?) and IL-18 Receptor beta (IL-18R?).

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.

Abstract: Provided herein is a photonic integrated circuit and methods for controlling a photonic integrated circuit that can utilize the resonant frequency of one or more components of the photonic integrated circuit to enhance the response of the circuit. At least one component of the photonic integrated circuit can be driven by an electrical signal whose frequency is substantially equal to the mechanical resonance frequency of the component such that the response of the optical component is increased. The component of the photonic integrated circuit can include a phase shifter that can impart a phase shift on a received optical signal. By driving the phase shifter with an electrical signal that is equal to the mechanical resonance frequency of the optical phase shifter, less power can be required to impart a desired phase shift on a received optical signal. The optical components can be implemented using piezoelectric cantilevers.

Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.

Abstract: A scalable point defect qubit control system may include a diamond waveguide array comprising one or more diamond waveguides and a microwave line disposed proximally to the diamond waveguide array. Each diamond waveguide in the diamond waveguide array may include one or more qubits encoded in point defect sites. The microwave line may be configured to receive a direct current (DC) signal configured to shift an energy level of each point defect qubit of the one or more point defect qubits based on a position of the point defect in the diamond waveguide array, and receive an alternating current (AC) signal configured to control a quantum state of a point defect qubit of the one or more point defect qubits, wherein one or more properties of the AC signal are based on the shift in the energy level induced by the DC signal.

Abstract: A method for controlling a qubit encoded in an atom-like defect in a solid-state host may comprise applying an electrical signal to a piezoelectric cantilever that is mechanically coupled to a photonic waveguide comprising one or more embedded point defect sites. The photonic waveguide may be optically coupled to a photonic chip. Applying the electrical signal to the piezoelectric cantilever may induce movement in the piezoelectric cantilever, which may induce a strain in the photonic waveguide. The applied electrical signal may be determined by a defect site with excitation light, measuring a frequency of a photon emitted by the excited defect site, determining a frequency shift based on the measured frequency of the emitted photon, and determining the electrical signal to be applied to the piezoelectric cantilever based on the frequency shift.

Abstract: Provided herein is a photonic modulator and methods for controlling a photonic modulator that can control the phase and/or amplitude of photons being transmitted through the modulator to minimize photonic loss while remaining power efficient and operating at high speeds. The photonic modulator can include a substrate with a pair of piezoelectric cantilevers spaced apart from one another by a gap, with a photonic waveguide disposed in the substrate that extends across the modulator and bridges the gap between the piezoelectric cantilevers. In one or more examples, the piezoelectric cantilevers can be configured to move away from the substrate in response to an electrical signal, such that a refractive index of the photonic waveguide is altered.

Abstract: Disclosed herein are a system on chip, a method of operating the system on chip, and an electronic device including the system on chip that execute artificial intelligence (AI) algorithms and/or machine learning algorithms in a 5G environment connected for Internet of Things in order to prevent an artificial intelligence product from being surreptitiously used, replaced, or modified by an attacker.

Abstract: Disclosed herein are a system on chip, a method of operating the system on chip, and an electronic device including the system on chip that execute artificial intelligence (AI) algorithms and/or machine learning algorithms in a 5G environment connected for Internet of Things in order to prevent an artificial intelligence product from being surreptitiously used, replaced, or modified by an attacker.