Patents by Inventor Mark Donowitz

Mark Donowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions which regulate the epithelial brush border Na/H exchanger NHE3 and their methods of use in gastrointestinal disease
    Patent number: 9850292
    Abstract: A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: December 26, 2017
    Assignees: The Johns Hopkins University, The Penn State Research Foundation
    Inventors: Mark Donowitz, Nicholas Constantine Zachos, Damian Brett Van Rossum, Randen Patterson
  • COMPOSITIONS WHICH REGULATE THE EPITHELIAL BRUSH BORDER Na+/H+ EXCHANGER NHE3 AND THEIR METHODS OF USE IN GASTROINTESTINAL DISEASE
    Publication number: 20150139956
    Abstract: A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 21, 2015
    Inventors: Mark Donowitz, Nicholas Constantine Zachos, Damian Brett Van Rossum, Randen Patterson
  • TREATMENT OF METASTATIC COLON CANCER WITH B-SUBUNIT OF SHIGA TOXIN
    Publication number: 20110201561
    Abstract: The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further provides methods of identifying compounds usefully for the treatment of invasive or metastatic cancer, particularly metastatic colon cancer.
    Type: Application
    Filed: January 18, 2011
    Publication date: August 18, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Olga N. Kovbasnjuk, Mark Donowitz
  • Treatment of metastatic colon cancer with b-subunit of shiga toxin
    Patent number: 7875586
    Abstract: The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further provides methods of identifying compounds usefully for the treatment of invasive or metastatic cancer, particularly metastatic colon cancer.
    Type: Grant
    Filed: December 20, 2003
    Date of Patent: January 25, 2011
    Assignee: The Johns Hopkins University
    Inventors: Olga N. Kovbasnjuk, Mark Donowitz
  • Treatment of metastatic colon cancer with b-subunit of shiga toxin
    Publication number: 20070071772
    Abstract: The present invention relates to compositions and methods for treating invasive or metastatic cancer, particularly metastatic colon cancer using the B-submit of shiga toxin. The invention further provides methods of identifying compounds usefully for the treatment of invasive or metastatic cancer, particularly metastatic colon cancer.
    Type: Application
    Filed: December 20, 2003
    Publication date: March 29, 2007
    Inventors: Olga Kovbasnjuk, Mark Donowitz
  • Human NHE3 protein and non-human cells expressing same
    Patent number: 6392025
    Abstract: This invention presents the cloning and characterization of human NHE3. It sets forth the entire coding region of the human NHE3 cDNA as well as the encoded protein, an 834 amino acid protein with a calculated relative molecular weight of 92,906.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: May 21, 2002
    Assignee: Tranzmembrane, LLC
    Inventors: Steven R. Brant, C. H. Chris Yun, Mark Donowitz
  • Method of identifying agents that affect human NHE3
    Patent number: 5871919
    Abstract: The present invention teaches a method of identifying agents that affect NHE3. Specifically, these methods comprise the steps of obtaining DNA encoding all or a portion of human NHE3, introducing that DNA into a recipient host cell whereby the host cell can perform Na+/H+ exchange, applying agents to the host cell, and assessing whether the agents affect Na+/H+ exchange.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: February 16, 1999
    Inventors: Steven R. Brant, C.H. Chris Yun, Mark Donowitz, Chung-Ming Tse