Abstract: Disclosed herein are methods and apparatus for making a determination whether a blood sample is, or is not, infected with a malaria parasite. The determination is made using a trained machine-learning (ML) algorithm. In some aspects, a microfluidic chip is used for the concentration of red blood cells infected with these parasites from uninfected red blood cells, the staining of the blood sample which differentially stains infected and uninfected red blood cells, and holds the sample of interest for imaging. The microfluidic chip is inserted into an optical subsystem that magnifies the image created from transmitted light microscopy. The magnified image is captured with a camera, and a trained ML algorithm assesses if the sample does or does not contain the parasite. Generally, the ML algorithm is executed on a portable computing device such as a smartphone.

Abstract: This disclosure relates to, in part, the treatment of an organic acidemia in a subject in need thereof via administration of a therapeutically effective amount of compounds that inhibit BCAT2. The disclosure also relates to, in part, methods for identifying a candidate compound for treatment of organic acidemias.

Abstract: Disclosed herein are methods and apparatus for making a determination whether a blood sample is, or is not, infected with a malaria parasite. The determination is made using a trained machine-learning (ML) algorithm. In some aspects, a microfluidic chip is used for the concentration of red blood cells infected with these parasites from uninfected red blood cells, the staining of the blood sample which differentially stains infected and uninfected red blood cells, and holds the sample of interest for imaging. The microfluidic chip is inserted into an optical subsystem that magnifies the image created from transmitted light microscopy. The magnified image is captured with a camera, and a trained ML algorithm assesses if the sample does or does not contain the parasite. Generally, the ML algorithm is executed on a portable computing device such as a smartphone.

Abstract: A non-invasive, continuous, and direct system for detecting the presence of malaria parasites that exploits the paramagnetic properties of hemozoin in red blood cells. An electromagnetic probe (EM probe) is comprised of a dual coaxial coil used to detect iron oxide particles by using sensitive lock-in amplification of detector voltage or phase shift.

Abstract: Devices, methods, and non-transitory program storage devices are disclosed herein to provide improved image processing, the techniques comprising: obtaining an input image and target image data, and then calculating derivatives for the target image data using a regularized derivative kernel operator. In some embodiments, the regularized operator may comprise the following operator: [?1 (1+?)], wherein ? may be a controllable system parameter and preferably is independent of the particular type of image processing being applied to the image. In some embodiments, the techniques may find look-up table (LUT) mappings or analytical functions to approximate the derivative structure of the target image data. Finally, the techniques disclosed herein may generate an output image from the input image based on attempting to closely approximate the calculated derivatives for the target image data. In preferred embodiments, by controlling the mapping, e.g.

Abstract: Devices, methods, and non-transitory program storage devices are disclosed herein to provide improved image processing, the techniques comprising: obtaining an input image and target image data, and then calculating derivatives for the target image data using a regularized derivative kernel operator. In some embodiments, the regularized operator may comprise the following operator: [?1 (1+?)], wherein ? may be a controllable system parameter and preferably is independent of the particular type of image processing being applied to the image. In some embodiments, the techniques may find look-up table (LUT) mappings or analytical functions to approximate the derivative structure of the target image data. Finally, the techniques disclosed herein may generate an output image from the input image based on attempting to closely approximate the calculated derivatives for the target image data. In preferred embodiments, by controlling the mapping, e.g.

Abstract: A non-invasive, continuous, and direct system for detecting the presence of malaria parasites that exploits the paramagnetic properties of hemozoin in red blood cells. An electromagnetic probe (EM probe) is comprised of a dual coaxial coil used to detect iron oxide particles by using sensitive lock-in amplification of detector voltage or phase shift.

Abstract: In accordance with some embodiments, a system includes a line locator and a device configured to communicate through an internet with a server also coupled to the internet. Furthermore, a plurality of line locate transmitters are distributed geographically and configured to communicate through the internet with the server. The server operates to activate one of the plurality of line locate transmitters based on a geographic location of the device.

Abstract: In accordance with some embodiments, a system includes a line locator and a device configured to communicate through an internet with a server also coupled to the internet. Furthermore, a plurality of line locate transmitters are distributed geographically and configured to communicate through the internet with the server. The server operates to activate one of the plurality of line locate transmitters based on a geographic location of the device.

Abstract: The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Abstract: A method and system for producing a scalar image from a derivative field and a vector image is disclosed. A function class c is selected, where all members of the class c are functions which map each vector of the vector image to a unique scalar value. A function f is selected from the class c which maps the vector image to a scalar image, the derivative of which is closest to the derivative field. The scalar image is generated from the vector image by using f to calculate each scalar value in the scalar image from a corresponding vector in the vector image.

Abstract: The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Abstract: A method and system for producing a scalar image from a derivative field and a vector image is disclosed. A function class c is selected, where all members of the class c are functions which map each vector of the vector image to a unique scalar value. A function f is selected from the class c which maps the vector image to a scalar image, the derivative of which is closest to the derivative field. The scalar image is generated from the vector image by using f to calculate each scalar value in the scalar image from a corresponding vector in the vector image.

Abstract: This invention relates to inhibitors of CETP and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by CETP.