Abstract: A post-cervical insemination catheter assembly including a cannula; a guide catheter slideably positioned about said cannula; and, a tip element securely connected to a distal end of said cannula. The tip element is configured to receive fluid from the cannula and dispense the fluid from a tip element outlet end. The tip element outlet end remains closed when loading the cannula through a vaginal canal and when traversing a cervix of the animal and then automatically opens when sufficient fluid pressure in the tip element is applied, thus enhancing injection of fluid to the utero-tubal junction, bio-secure delivery of fluids from any attached container, and a much safer less invasive experience for the recipient then prior post-cervical artificial insemination (PCAI) catheter assemblies.

Abstract: Disclosed are methods and compositions for treating or preventing diseases or disorders associated with mitochondrial calcium uniporter (MCU) activity. The methods may include administering a modulator of MCU activity to a patient in need thereof.

Abstract: Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.

Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

Abstract: Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.

Abstract: Methods, systems, and tool assemblies for distributing weight between a bit and a reamer device are disclosed. For example, at least one of the drill bit and the reamer may be configured to selectively distribute a weight-on-bit between the drill bit and the reamer, such as within a predetermined range. Additionally, methods of drilling wellbores may include selectively distributing a weight-on-bit applied to a bottom hole assembly between a drill bit and a reamer of the bottom hole assembly. Also, a reamer may be configured to exhibit a first maximum rate-of-penetration into a relatively hard formation, and a drill bit may be configured to exhibit a second maximum rate-of-penetration into a relatively soft formation that is less than the first maximum rate-of-penetration.

Abstract: Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.

Abstract: A spinal fixation assembly has a bone screw with head having a continuously curved spherical outer surface. The curved surface nests in a split annular bushing having a plurality of segments curving around the screw head. The bushing has an outward extending flange that fits into a recess in a socket in a fixation plate. The plate has at least three legs which extend from ends of a cross-member to form one of an H shaped, X shaped or A shaped configuration. Each socket is curved to rotatably receive rotation of the bushing. The socket recess is larger than the bushing flange to allow the bushing to tilt a predetermined amount depending on a thickness of the outward extending flange.

Abstract: A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.

Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

Abstract: A meter pit lid plug and bracket assembly configured to suspend a transmitter plug inside a meter pit is provide. The meter pit lid plug and bracket assembly includes a plug and a bracket. The plug includes a head and a stem that extends from the head. The stem is also configured to extend through a hole in a meter pit having a top surface. The head is sized to rest on the top surface of the meter pit lid and is configured to hold the stem in the hole. The bracket is configured to hold the transmitter plug inside the meter pit. The stem is selectively engageable with the base so that when the stem is connected with the base, both the plug and bracket are configured to hold and suspend the transmitter plug inside the meter box.

Abstract: Earth-boring drill bits include a bit body including a blockage-resistant internal fluid passageway. The blockage-resistant internal fluid passageway includes at least one internal fluid passageway formed in the bit body and a cuttings filtering feature formed in the at least one internal fluid passageway configured to prevent at least some cuttings from flowing through the at least one internal fluid passageway. In one embodiment, the cuttings filtering feature includes at least one lateral member extending transversely across the at least one internal fluid passageway. In another embodiment, the cuttings filtering feature includes forming a central portion of the at least one internal fluid passageway with a width along a lateral axis thereof less than an average width of a fluid path extending through a nozzle disposed at least partially within the at least one internal fluid passageway. Methods of forming the blockage-resistant internal fluid passageway are also disclosed.

Abstract: An expandable apparatus for use in a borehole includes a tubular body having at least one opening extending between a longitudinal bore of the tubular body and an outer surface of the tubular body and at least one member positioned within the at least one opening of the tubular body. The at least one member is configured to move between a retracted position and an extended position. An actuation structure is positioned within the tubular body. The actuation structure is coupled to the at least one member and is configured to move the at least one member from the retracted position to the extended position responsive to a flow rate of drilling fluid passing through the longitudinal bore.

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract.

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract.

Abstract: A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract.

Abstract: Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.

Abstract: An apparatus for engaging a subterranean borehole includes a bi-center bit having backup cutting elements thereon. The bi-center bit includes a pilot bit section and a reamer bit section adjacent to the pilot bit section. The pilot bit section includes at least one primary cutting element and at least one backup cutting element rotationally trailing and laterally offset from the at least one primary cutting element. Methods of drilling a subterranean borehole include engaging a first portion of a borehole with a reamer bit section of a drill bit and simultaneously engaging a second, opposing portion of the borehole with a pilot bit section adjacent to the reamer bit section.