Patents by Inventor Mark E. Davis

Mark E. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150322207
    Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Inventors: MARK E. DAVIS, AKINLEYE ALABI
  • Patent number: 9132097
    Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 15, 2015
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Han Han
  • Patent number: 9116128
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 25, 2015
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Patent number: 9108982
    Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 18, 2015
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Joshua J. Pacheco
  • Patent number: 9108979
    Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 18, 2015
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Joshua Pacheco
  • Publication number: 20150230202
    Abstract: A mobile station for notification of a circuit switched event. The mobile station includes a circuit switched modem, a packetized data modem, a radio, and a tune away controller. The circuit switched communicates circuit switched data over a circuit switched network. The packetized data modem communicates packetized data over a packetized data network. The radio couples the packetized data modem to the packetized data network via a packetized data radio link, and couples the circuit switched modem to the circuit switched network via a circuit switched radio link. The tune away controller is coupled to the circuit switched modem and to the packetized data modem, and indicates tune away events over the packetized data network and notice the mobile station to process the circuit switched event, where the tune away controller directs switching of the radio between the packetized data radio link and the circuit switched radio link.
    Type: Application
    Filed: April 17, 2015
    Publication date: August 13, 2015
    Inventors: Mark E. DAVIS, Anthony S. LEE
  • Publication number: 20150203634
    Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.
    Type: Application
    Filed: September 3, 2014
    Publication date: July 23, 2015
    Inventors: Mark E. Davis, Hector Gonzalez, Suzie Hwang Pun
  • Publication number: 20150202603
    Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having HEU topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 23, 2015
    Inventors: JOEL E. SCHMIDT, MARK E. DAVIS
  • Publication number: 20150203358
    Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having IWV topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation templates.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 23, 2015
    Inventors: JOEL E. SCHMIDT, MARK E. DAVIS
  • Publication number: 20150202612
    Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having RTH topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 23, 2015
    Inventors: JOEL E. SCHMIDT, MARK E. DAVIS
  • Publication number: 20150203357
    Abstract: This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly those having CIT-7 topologies having a range of Si:Al ratios, methods of preparing these and known crystalline microporous solids using certain quaternized imidazolium cation structuring agents.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 23, 2015
    Inventors: JOEL E. SCHMIDT, MARK E. DAVIS
  • Publication number: 20150165055
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Application
    Filed: July 21, 2014
    Publication date: June 18, 2015
    Applicant: CERULEAN PHARMA INC.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Publication number: 20150141670
    Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.
    Type: Application
    Filed: December 5, 2014
    Publication date: May 21, 2015
    Inventors: MARK E. DAVIS, JOSHUA J. PACHECO
  • Publication number: 20150117315
    Abstract: A mobile station for notification of a circuit switched event. The mobile station includes a circuit switched modem, a packetized data modem, a radio, and a tune away controller. The circuit switched communicates circuit switched data over a circuit switched network. The packetized data modem communicates packetized data over a packetized data network. The radio couples the packetized data modem to the packetized data network via a packetized data radio link, and couples the circuit switched modem to the circuit switched network via a circuit switched radio link. The tune away controller is coupled to the circuit switched modem and to the packetized data modem, and indicates tune away events over the packetized data network and notice the mobile station to process the circuit switched event, where the tune away controller directs switching of the radio between the packetized data radio link and the circuit switched radio link.
    Type: Application
    Filed: December 30, 2014
    Publication date: April 30, 2015
    Inventors: MARK E. DAVIS, ANTHONY S. LEE
  • Publication number: 20150110712
    Abstract: A composition and method for preparing molecular sieves having a STW framework structure are described wherein a structure directing agent comprising quaternary cation 1,2,3,4,5-pentamethyl-1H-imidazol-3-ium is contacted with a source of an oxide of a first tetravalent element with or without a source of an oxide of another tetravalent elements and/or a source of a trivalent element in a molar ratio of tetravalent element: trivalent element 100:1 and greater.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Joel E. SCHMIDT, Mark E. DAVIS
  • Patent number: 8974814
    Abstract: The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any combination or mixture thereof. The layered nature of the current monofilament polymeric monofilament device provides the capability to modulate the release of one or more drugs and/or the mechanical properties of the fiber so that drug release and device failure can be separately tuned to provide for the tailored introduction of therapeutically effective drugs or agents to a target tissue. Moreover, the fiber may comprise more than one distinct segments along its length, each segment itself having different combinations and/or numbers of layers thereby providing even greater freedom in the design of the therapeutic delivery device. The invention is also directed to a method of manufacturing such a layered polymeric monofilament fiber drug delivery device, and methods of treatment using such devices.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: March 10, 2015
    Assignee: California Institute of Technology
    Inventors: Brendan C. Mack, Mark E. Davis, Kenneth W. Wright
  • Patent number: 8968714
    Abstract: Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: March 3, 2015
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Akinleye Alabi
  • Publication number: 20150056129
    Abstract: The present disclosure is directed to methods of catalytically reducing carbon dioxide, each method comprising: contacting a composition comprising a spinel-type transition iron oxide with an alkali metal carbonate, bicarbonate, or mixture thereof at a first temperature to form CO, and an alkali metal ion-transition metal oxide; hydrolytically extracting at least a portion of alkali metal ions from the alkali metal ion-transition metal oxide by the reaction with CO2 and liquid H2O at a second temperature; and thermochemically reducing the transition metal composition of the second step at a third temperature, with the associated formation of O2.
    Type: Application
    Filed: November 5, 2014
    Publication date: February 26, 2015
    Inventors: MARK E. DAVIS, BINGJUN XU
  • Publication number: 20150050233
    Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.
    Type: Application
    Filed: March 4, 2014
    Publication date: February 19, 2015
    Applicants: CALANDO PHARMACEUTICALS, INC., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Suzie Hwang Pun, Hector Gonzalez, Mark E. Davis, Nathalie C. Bellocq, Jianjun Cheng
  • Patent number: 8953587
    Abstract: A mobile station for notification of a circuit switched event. The mobile station includes a circuit switched modem, a packetized data modem, a radio, and a tune away controller. The circuit switched communicates circuit switched data over a circuit switched network. The packetized data modem communicates packetized data over a packetized data network. The radio couples the packetized data modem to the packetized data network via a packetized data radio link, and couples the circuit switched modem to the circuit switched network via a circuit switched radio link. Only one of the links may be active at a time. The tune away controller is coupled to the circuit switched modem and to the packetized data modem, and indicates tune away events over the packetized data network so that the circuit switched event is processed by the mobile station. The tune away controller directs switching between the links.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: February 10, 2015
    Assignee: C.W. Investment Services Ltd.
    Inventors: Mark E. Davis, Anthony S. Lee