Patents by Inventor Mark E. Ewen

Mark E. Ewen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding p107 tumor suppressor and related polypeptides
    Patent number: 5962315
    Abstract: A cDNA encodes p107; a cell contains recombinant p107-encoding DNA; and substantially all of the cells of a nonhuman mammal contain recombinant p107-encoding DNA. Also, a method for diagnosing a condition of tumorigenicity in a subject, includes the steps of obtaining a tissue sample from the subject and detecting the presence of non wild-type p107-encoding gene in the sample, or detecting the absence of wild-type p107-encoding gene in the sample; or extracting DNA from the sample and detecting the presence of non wild-type p107-encoding gene or the absence of wild-type p107-encoding gene in the DNA. Also, a nucleic acid probe is complementary to a portion of a human mutant p107 gene.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: October 5, 1999
    Assignee: Dana-Farber Cancer Institute
    Inventors: David M. Livingston, Mark E. Ewen
  • DNA encoding p107 tumor suppressor
    Patent number: 5262321
    Abstract: A cDNA encodes p107; a cell contains recombinant p107-encoding DNA; and substantially all of the cells of a nonhuman mammal contain recombinant p107-encoding DNA. Also, a method for diagnosing a condition of tumorigenicity in a subject, includes the steps of obtaining a tissue sample from the subject and detecting the presence of non wild-type p107-encoding gene in the sample, or detecting the absence of wild-type p107-encoding gene in the sample; or extracting DNA from the sample and detecting the presence of non wild-type p107-encoding gene or the absence of wild-type p107-encoding gene in the DNA. Also, a nucleic acid probe is complementary to a portion of a human mutant p107 gene.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: November 16, 1993
    Assignee: Dana-Farber Cancer Institute
    Inventors: David M. Livingston, Mark E. Ewen