Patents by Inventor Mark E. Jones

Mark E. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047602
    Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.
    Type: Application
    Filed: November 2, 2020
    Publication date: February 18, 2021
    Applicant: Terumo BCT, Inc.
    Inventors: Boah VANG, Brian J. NANKERVIS, Mark E. JONES
  • Publication number: 20200255786
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: April 27, 2020
    Publication date: August 13, 2020
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Mark E. JONES
  • Publication number: 20200248126
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 6, 2020
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Mark E. JONES
  • Patent number: 10633625
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: April 28, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Brian J. Nankervis, Mark E. Jones
  • Patent number: 10557112
    Abstract: Described are embodiments for expanding cells in a bioreactor. In embodiments, methods and systems are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: February 11, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Nathan D. Frank, Mark E. Jones
  • Publication number: 20190119628
    Abstract: Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other embodiments, the cells may be grown in co-culture with other cells, e.g., hMSC's. In embodiments, the cells may include CD34+cells.
    Type: Application
    Filed: May 25, 2017
    Publication date: April 25, 2019
    Applicant: Terumo BCT, Inc.
    Inventor: Mark E. JONES
  • Publication number: 20190062683
    Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.
    Type: Application
    Filed: August 24, 2018
    Publication date: February 28, 2019
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Mark E. JONES, Domicinda M. HILL
  • Publication number: 20180291342
    Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 11, 2018
    Applicant: Terumo BCT, Inc.
    Inventors: Mark E. JONES, Brian J. NANKERVIS
  • Publication number: 20180282695
    Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.
    Type: Application
    Filed: April 2, 2018
    Publication date: October 4, 2018
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Domicinda M. HILL, Mark E. JONES
  • Publication number: 20180142199
    Abstract: Embodiments for loading and expanding particular cell types are described. Embodiments may include the use of hollow fiber membranes with particular characteristic such as hollow fibers with inner diameters that provide mechanical stimulus (e.g., radius of curvature greater than a dimension of a cell). In addition, embodiments may provide for manipulation of flow rates and other features that also provide mechanical stimuli and promote or enhance the growth of particular types of cells.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 24, 2018
    Applicant: Terumo BCT, Inc.
    Inventors: Mark E. JONES, Brian J. NANKERVIS, Kristina E. FUERST, Jon A. DODD
  • Publication number: 20170275580
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 28, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Nathan D. FRANK, Mark E. JONES
  • Patent number: 9695393
    Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: July 4, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Brian J. Nankervis, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
  • Patent number: 9617506
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: April 11, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Mark E. Jones, Nathan D. Frank
  • Publication number: 20150321915
    Abstract: The present disclosure provides a process and a system for producing dichlorine (Cl2).
    Type: Application
    Filed: July 17, 2015
    Publication date: November 12, 2015
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Eric E. Stangland, Daniel A. Hickman, Mark E. Jones, Simon G. Podkolzin, Shawn D. Feist
  • Publication number: 20150140653
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Applicant: Terumo BCT, INC.
    Inventors: Mark E. JONES, Nathan D. FRANK
  • Publication number: 20150140654
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Applicant: TERUMO BCT, INC.
    Inventors: Brian J. NANKERVIS, Mark E. JONES
  • Patent number: 8674149
    Abstract: Oxidatively halogenate methane by placing a feedstream that comprises methane, a source of halogen, a source of oxygen and, optionally, a source of diluent gas in contact with a first catalyst (e.g. a solid super acid or a solid super base) that has greater selectivity to methyl halide and carbon monoxide than to methylene halide, trihalomethane or carbon tetrahalide. Improve overall selectivity to methyl halide by using a second catalyst that converts at least part of the feedstream to a mixture of methyl halide, methylene halide, trihalomethane, carbon tetrahalide and unreacted oxygen, and placing that mixture in contact with the first catalyst which converts at least a portion of the methylene halide, trihalomethane and carbon tetrahalide to carbon monoxide, hydrogen halide and water.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: March 18, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Robert G. Bowman, Eric E. Stangland, Mark E. Jones, Dean M. Millar, Simon G. Podkolzin, Brien A. Stears, Richard M. Wehmeyer
  • Publication number: 20140051167
    Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.
    Type: Application
    Filed: August 20, 2013
    Publication date: February 20, 2014
    Applicant: Terumo BCT, Inc.
    Inventors: Brian J. NANKERVIS, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
  • Patent number: 8088957
    Abstract: The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: January 3, 2012
    Inventors: William J. Kruper, Jr., David J. Schreck, Kenneth L. Kearns, Richard D. Varjian, Mark E. Jones, Robert M. Campbell, Bruce D. Hook, John R. Briggs, Jeffrey G. Hippler
  • Publication number: 20110268648
    Abstract: The present disclosure provides a process and a system for producing dichlorine (Cl2).
    Type: Application
    Filed: April 28, 2011
    Publication date: November 3, 2011
    Applicant: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Eric E. Stangland, Daniel A. Hickman, Mark E. Jones, Simon G. Podkolzin, Shawn D. Feist