Patents by Inventor Mark E. Jones
Mark E. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12234441Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.Type: GrantFiled: November 2, 2020Date of Patent: February 25, 2025Assignee: Terumo BCT, Inc.Inventors: Boah Vang, Brian J. Nankervis, Mark E. Jones
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Patent number: 12043823Abstract: Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.Type: GrantFiled: March 23, 2022Date of Patent: July 23, 2024Assignee: Terumo BCT, Inc.Inventors: Mark E. Jones, Dalip Sethi, Dennis J. Hlavinka, Thomas J. Felt
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Patent number: 11965175Abstract: Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other embodiments, the cells may be grown in co-culture with other cells, e.g., hMSC's. In embodiments, the cells may include CD34+ cells.Type: GrantFiled: May 25, 2017Date of Patent: April 23, 2024Assignee: Terumo BCT, Inc.Inventor: Mark E. Jones
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Patent number: 11708554Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.Type: GrantFiled: April 24, 2020Date of Patent: July 25, 2023Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Mark E. Jones
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Patent number: 11702634Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.Type: GrantFiled: April 2, 2018Date of Patent: July 18, 2023Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Domicinda M. Hill, Mark E. Jones
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Patent number: 11667876Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.Type: GrantFiled: April 27, 2020Date of Patent: June 6, 2023Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Mark E. Jones
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Patent number: 11629332Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), for example.Type: GrantFiled: April 2, 2018Date of Patent: April 18, 2023Assignee: Terumo BCT, Inc.Inventors: Mark E. Jones, Brian J. Nankervis
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Patent number: 11624046Abstract: Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas exchange capabilities of a closed, automated cell expansion system may allow cells to be seeded at reduced cell seeding densities, for example. Parameters of the cell growth environment may be manipulated to load the cells into a particular position in the bioreactor for the efficient exchange of nutrients and gases. System parameters may be adjusted to shear any cell colonies that may form during the expansion phase. Metabolic concentrations may be controlled to improve cell growth and viability. Cell residence in the bioreactor may be controlled. In embodiments, the cells may include T cells. In further embodiments, the cells may include T cell subpopulations, including regulatory T cells (Tregs), helper, naïve, memory, or effector, for example.Type: GrantFiled: August 24, 2018Date of Patent: April 11, 2023Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Mark E. Jones, Domicinda M. Hill
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Patent number: 11608486Abstract: Embodiments for loading and expanding particular cell types are described. Embodiments may include the use of hollow fiber membranes with particular characteristic such as hollow fibers with inner diameters that provide mechanical stimulus (e.g., radius of curvature greater than a dimension of a cell). In addition, embodiments may provide for manipulation of flow rates and other features that also provide mechanical stimuli and promote or enhance the growth of particular types of cells.Type: GrantFiled: December 22, 2017Date of Patent: March 21, 2023Assignee: Terumo BCT, Inc.Inventors: Mark E. Jones, Brian J. Nankervis, Kristina E. Fuerst, Jon A. Dodd
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Publication number: 20220306978Abstract: Implementations are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In implementations, the cells may be exposed to a number of growth factors including a combination of recombinant growth factors. In other implementations, the cells may be grown in co-culture with other cells, e.g., hMSC's. In implementations, the cells may include CD34+ cells. A coated membrane includes a membrane having a first coating configured to promote cellular adhesion to the membrane and a second coating that includes a soluble protein moiety.Type: ApplicationFiled: March 23, 2022Publication date: September 29, 2022Inventors: Mark E. Jones, Dalip Sethi, Dennis J. Hlavinka, Thomas J. Felt
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Patent number: 10633625Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.Type: GrantFiled: November 14, 2014Date of Patent: April 28, 2020Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Mark E. Jones
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Patent number: 10557112Abstract: Described are embodiments for expanding cells in a bioreactor. In embodiments, methods and systems are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.Type: GrantFiled: April 7, 2017Date of Patent: February 11, 2020Assignee: Terumo BCT, Inc.Inventors: Nathan D. Frank, Mark E. Jones
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Patent number: 9695393Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.Type: GrantFiled: August 20, 2013Date of Patent: July 4, 2017Assignee: Terumo BCT, Inc.Inventors: Brian J. Nankervis, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
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Patent number: 9617506Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.Type: GrantFiled: November 14, 2014Date of Patent: April 11, 2017Assignee: Terumo BCT, Inc.Inventors: Mark E. Jones, Nathan D. Frank
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Publication number: 20150321915Abstract: The present disclosure provides a process and a system for producing dichlorine (Cl2).Type: ApplicationFiled: July 17, 2015Publication date: November 12, 2015Applicant: DOW GLOBAL TECHNOLOGIES LLCInventors: Eric E. Stangland, Daniel A. Hickman, Mark E. Jones, Simon G. Podkolzin, Shawn D. Feist
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Patent number: 8674149Abstract: Oxidatively halogenate methane by placing a feedstream that comprises methane, a source of halogen, a source of oxygen and, optionally, a source of diluent gas in contact with a first catalyst (e.g. a solid super acid or a solid super base) that has greater selectivity to methyl halide and carbon monoxide than to methylene halide, trihalomethane or carbon tetrahalide. Improve overall selectivity to methyl halide by using a second catalyst that converts at least part of the feedstream to a mixture of methyl halide, methylene halide, trihalomethane, carbon tetrahalide and unreacted oxygen, and placing that mixture in contact with the first catalyst which converts at least a portion of the methylene halide, trihalomethane and carbon tetrahalide to carbon monoxide, hydrogen halide and water.Type: GrantFiled: August 19, 2009Date of Patent: March 18, 2014Assignee: Dow Global Technologies LLCInventors: Robert G. Bowman, Eric E. Stangland, Mark E. Jones, Dean M. Millar, Simon G. Podkolzin, Brien A. Stears, Richard M. Wehmeyer
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Publication number: 20140051167Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.Type: ApplicationFiled: August 20, 2013Publication date: February 20, 2014Applicant: Terumo BCT, Inc.Inventors: Brian J. NANKERVIS, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
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Patent number: 8088957Abstract: The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.Type: GrantFiled: July 18, 2005Date of Patent: January 3, 2012Inventors: William J. Kruper, Jr., David J. Schreck, Kenneth L. Kearns, Richard D. Varjian, Mark E. Jones, Robert M. Campbell, Bruce D. Hook, John R. Briggs, Jeffrey G. Hippler
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Publication number: 20110268648Abstract: The present disclosure provides a process and a system for producing dichlorine (Cl2).Type: ApplicationFiled: April 28, 2011Publication date: November 3, 2011Applicant: DOW GLOBAL TECHNOLOGIES LLCInventors: Eric E. Stangland, Daniel A. Hickman, Mark E. Jones, Simon G. Podkolzin, Shawn D. Feist
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Publication number: 20110201841Abstract: Oxidatively halogenate methane by placing a feedstream that comprises methane, a source of halogen, a source of oxygen and, optionally, a source of diluent gas in contact with a first catalyst (e.g. a solid super acid or a solid super base) that has greater selectivity to methyl halide and carbon monoxide than to methylene halide, trihalomethane or carbon tetrahalide. Improve overall selectivity to methyl halide by using a second catalyst that converts at least part of the feedstream to a mixture of methyl halide, methylene halide, trihalomethane, carbon tetrahalide and unreacted oxygen, and placing that mixture in contact with the first catalyst which converts at least a portion of the methylene halide, trihalomethane and carbon tetrahalide to carbon monoxide, hydrogen halide and water.Type: ApplicationFiled: August 19, 2009Publication date: August 18, 2011Inventors: Robert G. Bowman, Eric E. Stangland, Mark E. Jones, Dean M. Millar, Simon G. Podkolzin, Brien A. Stears, Richard M. Wehmeyer