Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A transmission for an engine or motor with a reduced package size and increased efficiency comprising: an input sprocket, an output sprocket, a chain, and a planetary gear set. The output sprocket is drivingly connecting to the input sprocket through the chain. The output sprocket has a hollow center portion that receives the sun gear of the planetary gear set. The planetary gear set also includes at least two planet gears meshed with the sun gear which are mounted to a fixed planet carrier for driving a differential with a ring gear portion. When the input sprocket is rotated in a first direction, the chain drives the output sprocket and the sun gear in the first direction, and the sun gear drives the planet gears to rotate in a second direction, opposite the first direction, driving the ring gear portion and differential in the second direction.

Abstract: A transmission for an engine or motor with a reduced package size and increased efficiency comprising: an input sprocket, an output sprocket, a chain, and a planetary gear set. The output sprocket is drivingly connecting to the input sprocket through the chain. The output sprocket has a hollow center portion that receives the sun gear of the planetary gear set. The planetary gear set also includes at least two planet gears meshed with the sun gear which are mounted to a fixed planet carrier for driving a differential with a ring gear portion. When the input sprocket is rotated in a first direction, the chain drives the output sprocket and the sun gear in the first direction, and the sun gear drives the planet gears to rotate in a second direction, opposite the first direction, driving the ring gear portion and differential in the second direction.

Abstract: A chain having a plurality of inside links and guide links. The plurality of inside links each have a pair of apertures and are interleaved and connected to form rows. The plurality of guide links each have a pair of apertures and are placed outside of alternate rows of interleaved inside links to form guide rows. Connecting pins are received in the apertures and extend across the rows of the chain securing the links together. Spacing elements are found on opposite side of the chain, specifically between the guide links and the adjacent outermost inside links. The spacing elements act to maintain a spaced relationship between each of the guide link sand adjacent outermost inside links. At least one of the spacing elements on one side of the chain is a spring link holding the inside links in compressive frictional contact therebetween.

Abstract: A chain having a plurality of inside links and guide links. The plurality of inside links each have a pair of apertures and are interleaved and connected to form rows. The plurality of guide links each have a pair of apertures and are placed outside of alternate rows of interleaved inside links to form guide rows. Connecting pins are received in the apertures and extend across the rows of the chain securing the links together. Spacing elements are found on opposite side of the chain, specifically between the guide links and the adjacent outermost inside links. The spacing elements act to maintain a spaced relationship between each of the guide link sand adjacent outermost inside links. At least one of the spacing elements on one side of the chain is a spring link holding the inside links in compressive frictional contact therebetween.

Abstract: A power transmission chain having a plurality of inside links and guide links. Each inside link has at least one inverted tooth adapted to contact the teeth of an associated sprocket. Each link has a pair of apertures which are connected by connecting pins inserted through the apertures. The chain is provided with projections acting to maintain a spaced relationship between the guide links and the inside links. The spacing of the guide link away from the inside links is accomplished by spacing elements which may include projections formed on the guide link or an outer face of the outermost inside link, or by washers or spacers interposed therebetween.

Abstract: A power transmission chain having a plurality of inside links and guide links. Each inside link has at least one inverted tooth adapted to contact the teeth of an associated sprocket. Each link has a pair of apertures which are connected by connecting pins inserted through the apertures. The chain is provided with projections acting to maintain a spaced relationship between the guide links and the inside links. The spacing of the guide link away from the inside links is accomplished by spacing elements which may include projections formed on the guide link or an outer face of the outermost inside link, or by washers or spacers interposed therebetween.

Abstract: A power transmission chain having a plurality of inside links and guide links. Each inside link has at least one inverted tooth adapted to contact the teeth of an associated sprocket. Each link has a pair of apertures which are connected by connecting pins inserted through the apertures. The chain is provided with projections acting to maintain a spaced relationship between the guide links and the inside links. The spacing of the guide link away from the inside links is accomplished by spacing elements which may include projections formed on the guide link or an outer face of the outermost inside link, or by washers or spacers interposed therebetween.