Patents by Inventor Mark E. Shirtliff
Mark E. Shirtliff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11285293Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.Type: GrantFiled: December 11, 2018Date of Patent: March 29, 2022Assignees: University Of Maryland, Baltimore, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, Jr., Mark E. Shirtliff
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Publication number: 20210153841Abstract: A thermo-responsive ultrasound coupling gel that contains a thermo-responsive polymer such as poly(n-isopropyl acrylamide), the gel having a phase shift at a temperature in the range of 32 to 35° C. such that the gel has a loss factor G?/G? of >1 at <32° C. and a loss factor G?/G? of <1 at >35° C. The gel can also contain at least one of a solvent and gelling agent. Methods and uses for the thermo-responsive ultrasound coupling gel in an ultrasound and/or ultrasound guided procedure.Type: ApplicationFiled: March 6, 2019Publication date: May 27, 2021Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Paul E. BIGELEISEN, Kyle KENNEY, Mark E. SHIRTLIFF
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Publication number: 20190192814Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.Type: ApplicationFiled: December 11, 2018Publication date: June 27, 2019Inventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, JR., Mark E. Shirtliff
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Patent number: 10183144Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.Type: GrantFiled: November 6, 2014Date of Patent: January 22, 2019Assignees: The University of Maryland, Baltimore, The United States of America as represented by the Department of Veterans AffairsInventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, Jr., Mark E. Shirtliff
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Publication number: 20150126976Abstract: A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.Type: ApplicationFiled: November 6, 2014Publication date: May 7, 2015Inventors: Cha-Min Tang, Paul E. Bigeleisen, Samuel M. Galvagno, JR., Mark E. Shirtliff
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Patent number: 8697375Abstract: The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.Type: GrantFiled: September 2, 2009Date of Patent: April 15, 2014Assignees: University of Maryland, Baltimore, Arizona Board of Regents A Body Corporate of the State of ArizonaInventors: Mark E. Shirtliff, Rebecca A. Brady, Jeffrey G. Leid, Timothy L. Vail, Jennifer M. Kofonow
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Patent number: 8541006Abstract: The present invention provides methods and kits for biofilm detection.Type: GrantFiled: July 30, 2008Date of Patent: September 24, 2013Assignees: University of Maryland, Baltimore, The Arizona Board of Regents, a body corporate acting for and on behalf of Northern Arizona UniversityInventors: Jeffrey G. Leid, Timothy L. Vail, Jennifer M. Kofonow, Mark E. Shirtliff, Rebecca A. Brady
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Patent number: 8318180Abstract: Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment, prevention and prophylaxis of Staphylococcus aureus infections in a subject.Type: GrantFiled: September 23, 2009Date of Patent: November 27, 2012Assignees: University of Maryland, Baltimore, Northern Arizona UniversityInventors: Mark E. Shirtliff, Graeme O'May, Jeff Leid
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PROTECTIVE VACCINE AGAINST STAPHYLOCOCCUS AUREUS BIOFILMS COMPRISING CELL WALL-ASSOCIATED IMMUNOGENS
Publication number: 20110177111Abstract: Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment, prevention and prophylaxis of Staphylococcus aureus infections in a subject.Type: ApplicationFiled: September 23, 2009Publication date: July 21, 2011Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Mark E. Shirtliff, Graeme O'May, Jeff Leid -
Publication number: 20110171123Abstract: The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.Type: ApplicationFiled: September 2, 2009Publication date: July 14, 2011Applicant: University of Maryland, BaltimoreInventors: Mark E. Shirtliff, Rebecca A. Brady, Jeffrey G. Leid, Timothy L. Vail, Jennifer M. Kofonow
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Publication number: 20100285496Abstract: The present invention provides methods and kits for biofilm detection.Type: ApplicationFiled: July 30, 2008Publication date: November 11, 2010Applicant: University of Maryland BaltimoreInventors: Jeffrey G. Leid, Timothy L. Vail, Jennifer M. Kofonow, Mark E. Shirtliff, Rebecca A. Brady
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Publication number: 20080118893Abstract: An implantable dental screw comprising (i) an elongated body portion, which comprises a distal end and an external surface, which is axially threaded, (ii) a top portion, which is connected to the body portion at an end opposite to the distal end, and which comprises a proximal end, which comprises a seat that engages a tool for securing the screw into an osseotomy site and a chamfer that engages a dental prosthesis, and an external surface, (iii) at least one core channel disposed longitudinally within the screw and open at the proximal end and, optionally, at the distal end, and (iv) a plurality of delivery channels disposed within the body portion, each of which connects a core channel with the exterior of the screw; and a method of implanting the dental screw into a patient.Type: ApplicationFiled: March 7, 2006Publication date: May 22, 2008Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Debora B. Armellini, Mark E. Shirtliff, Alexander Pazoki, Liene Molly, Mark A. Reynolds