Patents by Inventor Mark E. Williams

Mark E. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240158398
    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: April 20, 2023
    Publication date: May 16, 2024
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian Lewis Hodous, Joseph L. Kim, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin
  • Publication number: 20240016153
    Abstract: Methods are provided to increase hybrid seed yield in wheat seed production. Methods for enhancing pollination success and limiting the proportion of self-fertilized male seed in the final produced seed stock are provided.
    Type: Application
    Filed: July 13, 2023
    Publication date: January 18, 2024
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARC C. ALBERTSEN, JESSIE LYNN ALT, BILL S. CURRAN, MARK E. WILLIAMS
  • Publication number: 20230407324
    Abstract: Methods of creating doubled haploid inducers are provided. These doubled haploid inducers are used in the production of maternal doubled haploids.
    Type: Application
    Filed: October 20, 2021
    Publication date: December 21, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: JON AARON TUCKER REINDERS, MARK E. WILLIAMS, HUAXUN YE
  • Publication number: 20220056472
    Abstract: Provided herein are methods and compositions for restoring fertility and maintaining sterility in plants. In particular, one method disclosed includes introducing into a male-sterile plant, wherein the plant comprises one or more homozygous mutations in a male-fertility gene, a plant restoration donor chromosomal component comprising a plant-derived polynucleotide that confers a plant phenotypic marker linked to a male-fertility restoration locus that functionally complements the male-sterility phenotype from the one or more homozygous mutations in the male-sterile plant. In some examples, the plant-derived polynucleotide that confers a plant phenotypic marker and the male-fertility restoration locus are linked to each other and located on the same chromosomal arm on the plant restoration donor chromosomal component. In some examples, the plant-derived polynucleotide that confers a plant phenotypic marker, the male-fertility restoration locus, or both are modified.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 24, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARC C ALBERTSEN, TIM FOX, MANJIT SINGH, MARK E WILLIAMS
  • Patent number: 10519721
    Abstract: The present disclosure relates to nested bearings and seals for use in roller cone drill bits. The bearing may include a bearing member, such as a flange or bushing, that is nested with a seal boss.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: December 31, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventor: Mark E. Williams
  • Patent number: 10458186
    Abstract: A well tool can include inner and outer seals interposed between components of the well tool, and a circumferential spacer which prevents contact between the inner seal and one of the components which displaces relative to the inner seal. A method of sealing between components of a well tool can include sealingly engaging an outer seal between the components, and disposing an inner seal between the components, including spacing the inner seal away from one of the components, whereby the inner seal sealingly contacts one of the components only after the well tool is disposed in a well. A drill bit can include inner and outer seals interposed between components of the drill bit, and a circumferential spacer which prevents contact between the inner seal and one of the components, the circumferential spacer being positioned upstream of the outer seal relative to a lubricant supply of the drill bit.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: October 29, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventor: Mark E. Williams
  • Publication number: 20190098858
    Abstract: Methods and compositions useful for avoiding plant meiosis and clonal reproduction through seed are provided herein. The present disclosure provides polynucleotides and related polypeptides of Spo11, Rec8, OSD1-1A, and OSD1-3A and methods and compositions for suppressing their expression level or activity.
    Type: Application
    Filed: March 17, 2017
    Publication date: April 4, 2019
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: MARC C ALBERTSEN, TIM WAYNE FOX, MARISSA SIMON, MARK E WILLIAMS
  • Patent number: 9988850
    Abstract: A downhole seal system for roller cone drill bits includes a seal gland having a width larger than it depth. In one implementation, the seal gland includes a protrusion along its base on which a seal element seats. The seal element is a single, annular seal element with a recess formed therein so as to define two lobes. The seal element seats in the gland so that the recess engages the protrusion. The lobes function as separate seal elements, although they are a single unitary seal element disposed in a single gland.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: June 5, 2018
    Assignee: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Micheal B. Crawford, Mark E. Williams, Young H. Lee, David P. Duckworth, Zhaohui Shan
  • Publication number: 20180142251
    Abstract: Methods and compositions used to prevent or decrease reduction, or reduction and recombination, during meiosis in female sporocyte, female gametophytes, or female gametes are described herein. The compositions and methods may include silencing elements and/or use gene-editing technology to decrease or inhibit Nrf4 expression levels or activity. Further provided are compositions and methods for the production of a plant that has ovules comprising non-reduced, or non-reduced and non-recombined, gametes, and/or seeds that contain clonal maternal embryos.
    Type: Application
    Filed: May 6, 2016
    Publication date: May 24, 2018
    Inventors: Tim W. Fox, Marc C. Albertsen, Mark E. Williams, Shai J Lawit, Mark A. Chamberlin, Ueli Grossniklaus, Gion Arco Brunner, Nina Chumak, Joana Bernardes De Asis, Frederique Pasquer
  • Publication number: 20180073302
    Abstract: The present disclosure relates to nested bearings and seals for use in roller cone drill bits. The bearing may include a bearing member, such as a flange or bushing, that is nested with a seal boss.
    Type: Application
    Filed: April 27, 2015
    Publication date: March 15, 2018
    Inventor: Mark E. Williams
  • Patent number: 9789942
    Abstract: In a watercraft storage system a “wishbone” or U-shaped cradle liftable and rotatable by an overhead crane comprises adjustable air filled hull supports to either side of a boat hull and a keel support toward the stern of the watercraft. The cradle central opening clears a cantilever storage rack support beam assembly allowing the watercraft to be lowered onto or raised from the cantilever storage rack support beam assembly by an overhead traveling crane. To substantially reduce any longitudinal swaying of the cradle and watercraft during raising and lowering, a system or diagonal anti-sway bracing cables that automatically retract and extend is employed. In the preferred embodiment, the cradle is lowered into a water-filled channel within the storage structure to re-float the watercraft. A watercraft to be stored can be brought into the channel which contains alignment means to accurately position the watercraft over the cradle.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: October 17, 2017
    Assignee: Maff-Stack, LLC
    Inventors: Christian F. Rosenberg, William C. Maffett, Brian D. Maffett, Mark E. Williams
  • Patent number: 9677341
    Abstract: An extended life seal is incorporated into a drill bit used for drilling a wellbore. The drill bit can include a seal surface, a seal which engages the seal surface, and a groove which compresses the seal greater on opposite axial sides than at a central portion of the seal. The drill bit may include the seal having a cylindrical surface which engages the seal surface, and another cylindrical surface opposite the first surface, and the groove having a third cylindrical surface which engages the second surface, and wherein the groove simultaneously biases the seal toward the seal surface on opposite axial sides of the third surface. The drill bit may include the seal having right cylindrical shaped inner and outer surfaces, and a contact pressure between the seal surface and the seal being greater at each opposite side of the seal than at a central portion of the seal.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: June 13, 2017
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Seth G. Anderle, Ping C. Sui, Mark E. Williams, Guy Lefort
  • Publication number: 20160194918
    Abstract: A well tool can include inner and outer seals interposed between components of the well tool, and a circumferential spacer which prevents contact between the inner seal and one of the components which displaces relative to the inner seal. A method of sealing between components of a well tool can include sealingly engaging an outer seal between the components, and disposing an inner seal between the components, including spacing the inner seal away from one of the components, whereby the inner seal sealingly contacts one of the components only after the well tool is disposed in a well. A drill bit can include inner and outer seals interposed between components of the drill bit, and a circumferential spacer which prevents contact between the inner seal and one of the components, the circumferential spacer being positioned upstream of the outer seal relative to a lubricant supply of the drill bit.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 7, 2016
    Inventor: Mark E. WILLIAMS
  • Publication number: 20150345226
    Abstract: A downhole seal system for roller cone drill bits includes a seal gland having a width larger than it depth. In one implementation, the seal gland includes a protrusion along its base on which a seal element seats. The seal element is a single, annular seal element with a recess formed therein so as to define two lobes. The seal element seats in the gland so that the recess engages the protrusion. The lobes function as separate seal elements, although they are a single unitary seal element disposed in a single gland.
    Type: Application
    Filed: December 31, 2012
    Publication date: December 3, 2015
    Inventors: Michael B. Crawford, Mark E. Williams, Young H. Lee, David P. Duckworth, Zhaohui Shan
  • Patent number: 9137957
    Abstract: Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant or plant part thereof. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: September 22, 2015
    Assignees: PIONEER HI BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANY
    Inventors: William B. Allen, Bo Shen, Mitchell C. Tarczynski, Mark E. Williams, Peizhong Zheng, Gan-Yuan Zhong
  • Patent number: 9121032
    Abstract: Methods of selecting haploid embryos are disclosed. Methods of producing haploid embryos and non-viable diploid embryos on a plant are provided. Methods for selecting haploid embryos produced from haploid inducer maize lines are provided. Methods for producing improved maize haploid inducer lines are disclosed. Maize haploid inducer lines comprising transgenes causing ablated or abnormal diploid embryos are disclosed.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: September 1, 2015
    Assignees: E I DU PONT DE NEMOURS AND COMPANY, PIONEER HI BRED INTERNATIONAL INC
    Inventors: Mark E. Williams, William J. Gordon-Kamm
  • Patent number: 8859846
    Abstract: Methods for producing doubled haploid corn (Zea mays) plants, seeds, and plant cells are provided.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: October 14, 2014
    Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: Joanne E. Barton, Sheila E. Maddock, Xinli E. Wu, Zuo-Yu Zhao, Mark E. Williams, Tanveer Hussain, William J. Gordon-Kamm
  • Patent number: 8748576
    Abstract: Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci genetically linked with QTL6 and which are associated with increased oil content and/or increased oleic acid content and/or an increased oleic acid/linoleic acid ratio of a plant. These novel markers are characterized by the presence of at least one polymorphism relative to the corresponding marker locus from the QTL6 region of non-high-oil, non-high-oleic acid maize plants. In some embodiments, the novel marker loci comprise coding sequence for a maize DGAT1-2 polypeptide or biologically active variant thereof. The marker loci of the invention, and suitable fragments thereof, are useful in methods for manipulating oil and/or oleic acid content and/or oleic acid/linoleic acid ratio of a plant, for marker-assisted selection of a plant, and for marker-assisted breeding of the high oil and/or high oleic acid trait.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: June 10, 2014
    Assignees: E I du Pont de Nemours and Company, Pioneer Hi-Bred International, Inc.
    Inventors: William B. Allen, Bo Shen, Mark E. Williams, Peizhong Zheng, Gan-Yuan Zhong
  • Patent number: 8652071
    Abstract: According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: February 18, 2014
    Assignee: University of Virginia Patent Foundation
    Inventor: Mark E. Williams
  • Patent number: 8652070
    Abstract: According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: February 18, 2014
    Assignee: University of Virginia Patent Foundation
    Inventor: Mark E. Williams