Patents by Inventor Mark Edward Brennan Smith
Mark Edward Brennan Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11654411Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: March 18, 2021Date of Patent: May 23, 2023Assignee: Illumina Cambridge LimitedInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20220016592Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: ApplicationFiled: March 18, 2021Publication date: January 20, 2022Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 10953379Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: December 9, 2019Date of Patent: March 23, 2021Assignee: Illumina Cambridge LimitedInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20200399692Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: ApplicationFiled: May 18, 2020Publication date: December 24, 2020Inventors: John MILTON, Xiaolin WU, Mark Edward Brennan SMITH, Joseph BRENNAN, Colin Lloyd BARNES, Xiaohai LIU, Silke RUEDIGER
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Publication number: 20200188871Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: ApplicationFiled: December 9, 2019Publication date: June 18, 2020Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20200017908Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula=C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is excType: ApplicationFiled: July 26, 2019Publication date: January 16, 2020Inventors: John MILTON, Xiaolin WU, Mark Edward Brennan SMITH, Joseph BRENNAN, Colin Lloyd BARNES, Xiaohai LIU, Silke RUEDIGER
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Patent number: 10525437Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: January 8, 2018Date of Patent: January 7, 2020Assignee: ILLUMINA CAMBRIDGE LIMITEDInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20180207606Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: ApplicationFiled: January 8, 2018Publication date: July 26, 2018Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 10010623Abstract: The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.Type: GrantFiled: February 5, 2013Date of Patent: July 3, 2018Assignee: UCL Business PLCInventor: Mark Edward Brennan Smith
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Patent number: 9889422Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: May 23, 2016Date of Patent: February 13, 2018Assignee: ILLUMINA CAMBRIDGE LIMITEDInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20160256846Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: ApplicationFiled: May 23, 2016Publication date: September 8, 2016Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 9376710Abstract: Methods and compositions are disclosed relating to the localization of nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: January 8, 2015Date of Patent: June 28, 2016Assignee: ILLUMINA CAMBRIDGE LTD.Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20150119295Abstract: Methods are disclosed relating to generating a silene-free slide comprising the steps of providing a plastic substrate; providing a solution of acrylamide comprising N-(5-bromoacetamidylpentyl) acrylamide (BRAPA); contacting the acrylamide/BRAPA solution with a polymerizing agent; contacting the acrylamide/BRAPA solution with an oxidizing agent; and contacting the acrylamide/BRAPA/polymerizing agent/oxidizing agent to the plastic substrate.Type: ApplicationFiled: January 8, 2015Publication date: April 30, 2015Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 8969258Abstract: Methods are disclosed relating to localizing nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: GrantFiled: October 14, 2013Date of Patent: March 3, 2015Assignee: Illumina Cambridge LimitedInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20150037360Abstract: The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.Type: ApplicationFiled: February 5, 2013Publication date: February 5, 2015Inventor: Mark Edward Brennan Smith
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Publication number: 20140100140Abstract: Methods are disclosed relating to localizing nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.Type: ApplicationFiled: October 14, 2013Publication date: April 10, 2014Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 8563477Abstract: A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5?-CAAGCAGAAGACGGCATACGA-3?; SEQ ID NO: 3); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5?-AATGATACGGCGACCACCGA-3?; SEQ ID NO: 4).Type: GrantFiled: July 13, 2012Date of Patent: October 22, 2013Assignee: Illumina Cambridge LimitedInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasalonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20130085084Abstract: A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5?-CAAGCAGAAGACGGCATACGA-3?); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5?-AATGATACGGCGACCACCGA-3?).Type: ApplicationFiled: July 13, 2012Publication date: April 4, 2013Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasolonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Publication number: 20110059865Abstract: The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate.Type: ApplicationFiled: January 7, 2005Publication date: March 10, 2011Inventors: Mark Edward Brennan Smith, Andrea Sabot, Isabelle Marie Julia Rasalonjatovo, Jean-Ernest Sohna Sohna, Adrian Martin Horgan, Harold Philip Swerdlow
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Patent number: 6593489Abstract: 3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) including the opposite enantiomers thereof, wherein R1 is either COOX, wherein X is selected from the group consisting of alkyl, H, and a salt-forming cation, or CH2OH, whererin the hydroxy group is optionally protected; R2 is H or a protecting group; R3 is H or alkyl, and R4 is selected from the group consisting of H, alkoxy, alkyl, aryl, and aralkyl; or, in the case of formula (1A), R2 and R4 are linked to form an oxazolidonone ring. These compounds can be used to prepare a series of complementary stereochemcially varied cyclopentane scaffolds.Type: GrantFiled: September 11, 2000Date of Patent: July 15, 2003Assignee: ChirotechTechnology LimitedInventors: Mark Edward Brennan Smith, Nadine Derrien