Abstract: Intravascular balloon catheters having one or more sets of spatial radiopaque markers circumferentially disposed around an inflatable balloon member or shaft for precise positioning of a stent. The spatial radiopaque markers may be positioned at a place of interest on the inflatable balloon member, such as the edges(s) of the working area or the proximal edge of a stent on the inflatable balloon member. In some embodiments, the spatial radiopaque markers appear as a ring structure when viewed non-orthogonally and as a two-dimensional line structure when viewed orthogonally under fluoroscopy. In some embodiments, a pattern of maximum width and space between a pair of shaft spatial markers is observed when viewed orthogonally under fluoroscopy. These provide the cardiac interventionist great confidence in proper positioning of a stent at an ostial lesion without expensive ultrasound imaging or added techniques and devices. Also disclosed are methods of making and using the same.