Patents by Inventor Mark Edward Eccleston

Mark Edward Eccleston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of isolating circulating nucleosomes
    Patent number: 12571051
    Abstract: The invention relates to methods for separating circulating cell free nucleosomes comprising linker DNA from a biological fluid sample, in particular nucleosomes of disease origin. Such methods allow for improved analysis of genetic and epigenetic markers associated with nucleosomes of disease origin.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: March 10, 2026
    Assignee: Belgian Volition SRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • CHIMERIC ANTIGEN RECEPTOR T-CELL TREATMENTS TARGETED TO CHROMATIN FRAGMENTS AND EXTRACELLULAR TRAPS
    Publication number: 20250170241
    Abstract: The invention relates to engineered immune cells comprising a chimeric antigen receptor or a T cell receptor, wherein said CAR or TCR comprises an antigen binding domain capable of specific binding to one or more epitopes associated with neutrophil extracellular traps.
    Type: Application
    Filed: March 1, 2023
    Publication date: May 29, 2025
    Inventors: Mark Edward ECCLESTON, Dmitry Dmitrievich GENKIN
  • HOMOGENEOUS IMMUNOASSAY METHOD
    Publication number: 20250012783
    Abstract: The invention relates to detecting the concentration of chromatin fragments in a body fluid sample using a homogeneous immunoassay (HIA) method.
    Type: Application
    Filed: October 28, 2022
    Publication date: January 9, 2025
    Inventors: Rémi RABEUF, Mark Edward ECCLESTON
  • STANDARDISATION OF NUCLEOSOME ASSAYS USING BIOLOGICALLY DERIVED CALIBRANTS
    Publication number: 20240369571
    Abstract: The present invention relates to methods and uses of a biologically derived nucleosome preparation which contains a defined amount or concentration of nucleosomes expressed in absolute units of mass or concentration as a calibrant in a comparative analytical procedure.
    Type: Application
    Filed: June 8, 2022
    Publication date: November 7, 2024
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Theresa K. KELLY
  • TRANSCRIPTION FACTOR BINDING SITE ANALYSIS OF NUCLEOSOME DEPLETED CIRCULATING CELL FREE CHROMATIN FRAGMENTS
    Publication number: 20240318255
    Abstract: The invention relates to methods for detecting disease in a subject by means of a minimally invasive body fluid test for non-nucleosomal cell free DNA fragments. The invention also relates to the measurement or detection of circulating cell free DNA fragments that include a transcription factor binding site sequence as an indicator of the presence of disease in a subject.
    Type: Application
    Filed: December 29, 2021
    Publication date: September 26, 2024
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG
  • CIRCULATING TRANSCRIPTION FACTOR ANALYSIS
    Publication number: 20240318226
    Abstract: The invention relates to methods for detecting disease in a subject by means of a minimally invasive body fluid test for the detection of circulating chromatin fragments that include a transcription factor and associated DNA sequence as an indicator of the presence of disease in the subject, e.g. cancer. The methods may comprise sequencing the associated DNA sequence and/or removing cell free nucleosomes from the body fluid.
    Type: Application
    Filed: December 29, 2021
    Publication date: September 26, 2024
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Dorian Fernand François PAMART, Marielle HERZOG
  • DIAGNOSTIC METHOD FOR MULTIPLE SCLEROSIS
    Publication number: 20240019432
    Abstract: The invention relates methods for diagnosing patients with multiple sclerosis by detecting cell free nucleosomes as biomarkers in body fluid samples.
    Type: Application
    Filed: December 8, 2021
    Publication date: January 18, 2024
    Inventors: Jason Bradley TERRELL, Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG
  • TRIAGING METHOD USING CELL FREE NUCLEOSOME LEVELS
    Publication number: 20230204599
    Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.
    Type: Application
    Filed: March 19, 2021
    Publication date: June 29, 2023
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Jason Bradley TERRELL
  • TRIAGING METHOD USING CELL FREE NUCLEOSOME LEVELS
    Publication number: 20230051905
    Abstract: The invention relates to using cell free nucleosome levels to identify patients at risk of developing a NETosis associated adverse reaction to the infection. The methods are used to monitor the progress of a disease and assigning a risk of an adverse outcome in a patient suffering from an infection.
    Type: Application
    Filed: August 25, 2022
    Publication date: February 16, 2023
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Jason Bradley TERRELL
  • USE OF CELL FREE NUCLEOSOMES AS BIOMARKERS
    Publication number: 20230003735
    Abstract: The invention relates to cell free nucleosomes as biomarkers in plasma samples for vascular or haematological cancers.
    Type: Application
    Filed: December 2, 2020
    Publication date: January 5, 2023
    Inventors: Jacob Vincent MICALLEF, Heather WILSON-ROBLES, Mark Edward ECCLESTON, Marielle Chantal Andree HERZOG, Jason Bradley TERRELL
  • METHOD FOR THE ENRICHMENT OF CIRCULATING TUMOR DNA
    Publication number: 20220334128
    Abstract: The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor origin or circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents.
    Type: Application
    Filed: June 7, 2022
    Publication date: October 20, 2022
    Inventors: Jacob Vincent MICALLEF, Marielle HERZOG, Mark Edward ECCLESTON
  • METHOD OF ISOLATING CIRCULATING NUCLEOSOMES
    Publication number: 20220290252
    Abstract: The invention relates to methods for separating circulating cell free nucleosomes comprising linker DNA from a biological fluid sample, in particular nucleosomes of disease origin. Such methods allow for improved analysis of genetic and epigenetic markers associated with nucleosomes of disease origin.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 15, 2022
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF
  • METHOD FOR THE DETECTION OF PROSTATE CANCER
    Publication number: 20220291221
    Abstract: The invention relates to a body fluid test method for the detection and treatment of prostate cancer, in particular aggressive prostate cancer. It also relates to monitoring of patients with low risk prostate tumours and selection of patients for prostate biopsy as well as selection of patients for prostate surgery or therapy.
    Type: Application
    Filed: May 1, 2020
    Publication date: September 15, 2022
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG, Jason Bradley TERRELL
  • METHOD FOR THE DETECTION OF CANCER
    Publication number: 20220221470
    Abstract: The invention relates to body fluid test methods for the detection of cancer using a combination biomarker panel comprising at least one cytokine molecule and at least one cell free chromatin fragment.
    Type: Application
    Filed: May 1, 2020
    Publication date: July 14, 2022
    Inventors: Jacob Vincent MICALLEF, Mark Edward ECCLESTON, Marielle HERZOG, Jason Bradley TERRELL
  • Method for detecting nucleosome adducts
    Patent number: 11193939
    Abstract: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers identified by said method.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: December 7, 2021
    Assignee: Belgian Volition SPRL
    Inventors: Jacob Vincent Micallef, Mark Edward Eccleston, Marielle Herzog
  • METHOD FOR THE ENRICHMENT OF CELL FREE NUCLEOSOMES
    Publication number: 20200340997
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Application
    Filed: July 14, 2020
    Publication date: October 29, 2020
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • Method for detecting nucleosomes containing histone modifications and variants
    Patent number: 10768182
    Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 8, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • Method for the enrichment of cell free nucleosomes
    Patent number: 10746746
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 18, 2020
    Assignee: Belgian Volition SPRL
    Inventors: Mark Edward Eccleston, Jacob Vincent Micallef
  • METHOD FOR DETECTING NUCLEOSOMES CONTAINING HISTONE MODIFICATIONS AND VARIANTS
    Publication number: 20190064183
    Abstract: The present invention relates to a method for detecting and measuring the presence of cell free mono-nucleosomes and oligo-nucleosomes that contain histone H1 or a histone H1 modification, variant or isoform, and the use of such measurements for the detection and diagnosis of disease.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 28, 2019
    Applicant: BELGIAN VOLITION SPRL
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF
  • METHOD FOR THE ENRICHMENT OF CELL FREE NUCLEOSOMES
    Publication number: 20190064184
    Abstract: The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 28, 2019
    Applicant: BELGIAN VOLITION SPRL
    Inventors: Mark Edward ECCLESTON, Jacob Vincent MICALLEF