Patents by Inventor Mark Edward Ruppen

Mark Edward Ruppen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processing for preparing monoprotected diols from symmetric diols
    Patent number: 6995001
    Abstract: This invention provides a two-step enzymatic process for the synthesis of monoprotected diols from symmetric diols.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: February 7, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Jianxin Gu, Mark Edward Ruppen
  • Glycopeptide antibiotics
    Patent number: 6964860
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 15, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Darren Robert Abbanat, Arthur Emery Bailey, Valerie Sue Bernan, Michael Greenstein, Jason Arnold Lotvin, Mark Edward Ruppen, Alan Gordon Sutherland, Haiyin He
  • Glycopeptide antibiotics
    Patent number: 6914045
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Darren Robert Abbanat, Valerie Sue Bernan, Russell George Dushin, Michael Greenstein, Haiyin He, Stanley Albert Lang, Howard Newman, Subas Sakya, Phaik-Eng Sum, Alan Gordon Sutherland, Ting-Zhong Wang, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur Emergy Bailey, Ping Cai, Bo Shen, Fangming Kong
  • Production of bicyclic-heteroaryl-2-carboxylic acids by selective enzymatic hydrolysis of a mixture of positional esters
    Publication number: 20040229324
    Abstract: The invention relates to an enzymatic process for the production of an intermediate, bicyclic-heteroaryl-2-carboxylic acid, of the formula 1
    Type: Application
    Filed: May 12, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Ramesh Venkat Matur, Mark Edward Ruppen
  • Calicheamicin derivative-carrier conjugates
    Publication number: 20040192900
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: November 3, 2003
    Publication date: September 30, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Antifungal antibiotics
    Publication number: 20040138302
    Abstract: This disclosure describes antifungal antibiotics designated Hygroscopene A, Hygroscopene B and Hygroscopene C to their production by fermentation, to methods for recovery and concentration from the crude solutions, to a process for purification and to new analogs of Hygroscopene A, Hygroscopene B and Hygroscopene C prepared by synthetic procedures.
    Type: Application
    Filed: December 18, 2003
    Publication date: July 15, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Ping Cai, Fangming Kong, Pamela Fink Charbonneau, Mark Edward Ruppen
  • Calicheamicin derivative-carrier conjugates
    Publication number: 20040082764
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: May 2, 2003
    Publication date: April 29, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
  • Processing for preparing monoprotected diols from symmetric diols
    Publication number: 20040067564
    Abstract: This invention provides a two-step enzymatic process for the synthesis of monoprotected diols from symmetric diols.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 8, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Jianxin Gu, Mark Edward Ruppen
  • Glycopeptide antibiotics
    Publication number: 20030092610
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 15, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Arthur Emery Bailey, Valerie Sue Bernan, Michael Greenstein, Jason Arnold Lotvin, Mark Edward Ruppen, Alan Gordon Sutherland, Haiyin He
  • Glycopeptide antibiotics
    Publication number: 20030087812
    Abstract: The invention provides compounds of formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: May 8, 2003
    Applicant: American Cyanamid Company
    Inventors: Darren Robert Abbanat, Valerie Sue Bernan, Russell George Dushin, Michael Greenstein, Haiyin He, Stanley Albert Lang, Howard Newman, Subas Sakya, Phaik-Eng Sum, Alan Gordon Sutherland, Ting-Zhong Wang, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur Emery Bailey, Ping Cai, Bo Shen, Fangming Kong