Abstract: A diagnostic apparatus includes a first array of superconducting quantum interference devices (SQUIDs). Each SQUID of the first array is configured to be coupled respectively to a test circuit of a second array of test circuits such that an electronic noise present in the test circuit induces a first current that flows through the SQUID. The diagnostic apparatus also includes a current source configured to provide a second current for each SQUID of the first array such that the second current flows through the SQUID. Each SQUID of the first array is configured to generate an output in a form of: a first voltage in response to a sum of the first current and the second current being less than a threshold current, and a second voltage in response to the sum of the first current and the second current being greater than the threshold current.

Abstract: Systems and methods for better utilizing available resources within a wireless telecommunication system. One aspect of the present invention is user equipment (UE) configured to autonomously determine its Maximum Sensitivity Degradation (MSD) value for a particular UE configuration. The MSD value is a function of (1) selected UE-specific parameters, such as those that are determined by the characteristics of the UE's RFFE components and RFFE architecture, and (2) selected standard parameters that may be dynamic or vary over time. Another aspect of the present invention is to configure a UE to provide its determined MSD value to a communications network, either as a raw value or as a computed indication of the MSD value relative to a specified reference value. The determined MSD value may then be used by a system controller to select a more efficient allocation of spectrum and network resources.

Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, the apparatus includes a negative pressure source, a connector port, at least one switch, and a controller. The negative pressure source is connected through the connector port to either (i) a wound dressing having a canister configured to store fluid aspirated from the wound or (ii) a wound dressing without a canister between the connector port and the wound dressing. The controller determines, based on a signal received from the at least one switch, whether the canister is positioned in the fluid flow path and adjusts one or more operational parameters of negative pressure wound therapy based on the determination. The switch is activated by the connection of either the canister or canisterless wound dressing to the apparatus.

Abstract: An ultrasonic atomization material applicator includes a material applicator with at least one transducer and an array plate with an array of micro-applicators. Each of the micro-applicators has a material inlet, a reservoir, and a micro-applicator plate with a plurality of apertures. At least one supply line is in communication with the micro-applicators and configured to supply at least one material to each of the micro-applicators. The at least one ultrasonic transducer is mechanically coupled to the at least one array of micro-applicators and configured to vibrate the at least one array of micro-applicators such that atomized droplets of the at least one material are ejected from each of the micro-applicators. A movement device configured to cyclically move the at least one array of micro-applicators back and forth about at least one axis of the at least one array of micro-applicators can be included.

Abstract: The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by HPK1.

Abstract: The disclosure provides an apparatus, system and method for a flexible heater suitable for embedding in a wearable. The flexible heater comprises a conformable substrate; a matched function ink set, printed onto at least one substantially planar face of the substrate to form at least a conductive layer capable of receiving current flow from at least one power source; a resistive layer electrically associated with the at least one conductive layer and comprising a plurality of heating elements capable of generating heat upon receipt of the current flow; and a dielectric layer capable of at least partially insulating the at least one resistive layer, wherein the matched ink set is matched to preclude detrimental interactions between the printed inks of each of the at least one conductive, resistive and dielectric layers, and to preclude detrimental interactions with the conformable substrate.

Abstract: An inflatable penile prosthesis may include a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer fluid between the fluid reservoir and the inflatable member. The pump assembly may include a pump bulb, a valve block, a plurality of valves disposed within the valve block, a first fluid port in fluid communication with the fluid reservoir, and a second fluid port in fluid communication with the inflatable member. The plurality of valves includes a control valve configured to move between an inflation position and a deflation position to control the flow of fluid within the valve block and the transfer of fluid between the fluid reservoir and the inflatable member.

Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

Abstract: Techniques are disclosed for systems including techniques for multi-feature balancing for natural langue processors. In an embodiment, a method includes receiving a natural language query to be processed by a machine learning model, the machine learning model utilizing a dataset of natural language phrases for processing natural language queries, determining, based on the machine learning model and the natural language query, a feature dropout value, generating, and based on the natural language query, one or more contextual features and one or more expressional features that may be input to the machine learning model, modifying at least one or the one or more contextual features and the one or more expressional features based on the feature dropout value to generate a set of input features for the machine learning model, and processing the set of input features to cause generating an output dataset for corresponding to the natural language query.

Abstract: Techniques for keyword data augmentation for training chatbot systems in natural language processing. In one particular aspect, a method is provided that includes receiving a training set of utterances for training a machine-learning model to identify one or more intents for one or more utterances, augmenting the training set of utterances with out-of-domain (OOD) examples. The augmenting includes: identifying keywords within utterances of the training set of utterances, generating a set of OOD examples with the identified keywords, filtering out OOD examples from the set of OOD examples that have a context substantially similar to context of the utterances of the training set of utterances, and incorporating the set of OOD examples without the filtered OOD examples into the training set of utterances to generate an augmented training set of utterances. Thereafter, the machine-learning model is trained using the augmented training set of utterances.

Abstract: This invention relates to systems and methods for redundant data center cooling and electrical systems.

Abstract: The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B) or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.

Abstract: Examples relate to cryogen flow control techniques using a magnetic failsafe valve. The valve is located between a cryogen source and a cryogen bath and has a position based on the magnetic field generated by a parallel solenoid circuit having a superconducting solenoid wound in a first direction and a non-superconducting solenoid (e.g., normal metal solenoid) wound in a second direction. When the current source is supplying a current to the parallel solenoid circuit and the temperature at the parallel solenoid circuit is below a threshold temperature, the current flows through the superconducting solenoid causing the magnetic field generated by the parallel solenoid circuit to position the magnetic valve in a particular state (e.g., open). The position of the valve can quickly change in situations where the temperature rises above the threshold temperature.

Abstract: The present invention relates to methods and uses of a biologically derived nucleosome preparation which contains a defined amount or concentration of nucleosomes expressed in absolute units of mass or concentration as a calibrant in a comparative analytical procedure.

Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.

Abstract: A wheelchair docking station for a wheelchair in a vehicle includes a first brace including a first brace arm, the first brace being mountable in the vehicle, and a second brace including a second brace arm, the second brace being mountable in the vehicle. The second brace is spaced from the first brace by a gap including a gap axis that is parallel to each of the first brace and the second brace. The first brace arm includes a first brace surface that is selectively shiftable toward the gap axis to engage a first wheel of the wheelchair, and the second brace arm includes a second brace surface that is selectively shiftable toward the gap axis to engage a second wheel of the wheelchair.

Abstract: According to an aspect, an inflatable penile prosthesis includes a fluid reservoir configured to hold fluid, an inflatable member, and a pump assembly configured to transfer the fluid between the fluid reservoir and the inflatable member, the pump assembly including a pump bulb, a valve body, a valve disposed within the valve body, a first fluid port configured to be fluidly coupled to the fluid reservoir, and a second fluid port configured to be fluidly coupled to the inflatable member, the valve being configured to move between an inflation position and a deflation position, wherein the valve body includes a sealing surface configured to engage the valve to form seal, the valve body includes a slot disposed adjacent the sealing surface.

Abstract: Accordingly, the inventor has conceived and reduced to practice, a system and method of farming using a computer controlled micro-environment suitable for soil-based and soilless growing media that is sustainable and totally automated from seed to harvest. The system utilizes software, sensor networks, and computing hardware that monitors and alters the environment in the growing units and provides nutrients, water, lighting, air flow, and temperature control specific to the crop being cultivated in one or a combination of vertical assemblies of growing units with electronically controlled features. Each unit is enabled to independently seed, cultivate, and produce a mature crop and discharge the contents for further processing for the intended market.

Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.

Abstract: Techniques for data analysis and user guidance are provided. One or more current measurements of one or more current analyte levels for the user are received from a sensor. A pattern is generated based on the one or more current measurements and the one or more past measurements. A first alignment with a first user target is then determined based on the pattern, where the first user target relates to one or more of a mental state or physical state of the user. A first result is output to the user, based on the determined first alignment.