Patents by Inventor Mark Eggena

Mark Eggena has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
    Patent number: 6074835
    Abstract: The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: June 13, 2000
    Assignees: Regents of the Univ. of California, Cedars-Sinai Medical Center
    Inventors: Johnathan Braun, Stephan R. Targan, Mark Eggena