Abstract: A method of optimizing underground drilling in which the Specific Energy, such as the Mechanical Specific Energy, is determined at a plurality of weight on bits and drill bit rotary speeds. The drilling operation is optimized by drilling at the operating conditions, including weight on bit and drill bit rotary speed, at which the standard deviation in Mechanical Specific Energy is a minimum. The drilling operation is monitored by determining the Mechanical Specific Energy and changing the operating parameters if the standard deviation in the Mechanical Specific Energy exceeds a predetermined value.

Abstract: A system and method for monitoring underground drilling in which vibration is monitored by creating a model of the drill string using finite element techniques or finite difference techniques and (i) predicting vibration by inputting real time values of operating parameters into the model, and then adjusting the model to agree with measured vibration data, (ii) predicting the weight on bit and drill string and mud motor speeds at which resonance will occur, as well as when stick-slip will occur, so that the operator can avoid operating regimes that will result in high vibration, (iii) determining vibration and torque levels along the length of the drill string based on the measured vibration and torque at one or more locations, (iv) determining the remaining life of critical components of the drill string based on the history of the vibration to which the components have been subjected, and (v) determining the optimum drilling parameters that will avoid excessive vibration of the drill string.

Abstract: A system and method for monitoring underground drilling in which vibration is monitored by creating a model of the drill string using finite element techniques or finite difference techniques and (i) predicting vibration by inputting real time values of operating parameters into the model, and then adjusting the model to agree with measured vibration data, (ii) predicting the weight on bit and drill string and mud motor speeds at which resonance will occur, as well as when stick-slip will occur, so that the operator can avoid operating regimes that will result in high vibration, (iii) determining vibration and torque levels along the length of the drill string based on the measured vibration and torque at one or more locations, (iv) determining the remaining life of critical components of the drill string based on the history of the vibration to which the components have been subjected, and (v) determining the optimum drilling parameters that will avoid excessive vibration of the drill string.

Abstract: An apparatus for measuring the bending on a drill bit operating down hole in a well may comprise at least three pockets circumferentially spaced equidistantly around the drill collar of the drill string to which the drill bit is attached. Four strain gauges are equidistantly circumferentially spaced around each of the pockets so as to form first and second sets of strain gauges. The strain gauges in the first set are connected into one Wheatstone bridge while the gauges in the second set are connected in a second bridge. Each of the strain gauges that are oriented similarly within each of the pockets are connected in series within a single leg of a bridge so that the output voltage of the bridge is unaffected by bending in the drill string. The output of first bridge is used to determine the bending on the drill bit.

Abstract: A system for damping vibration in a drill string can include a valve assembly having a supply of a fluid, a first member, and a second member capable of moving in relation to first member in response to vibration of the drill bit. The first and second members define a first and a second chamber for holding the fluid. Fluid can flow between the first and second chambers in response to the movement of the second member in relation to the first member. The valve assembly can also include a coil or a valve for varying a resistance of the fluid to flow between the first and second chambers.

Abstract: An apparatus and method for damping vibration, especially torsional vibration due to stick-slip, in a drill string, Sensors measure the instantaneous angular velocity of the drill string at one or more locations along the length of the drill string. One or more vibration damping modules are also spaced along the length of the drill string. When torsional vibration above a threshold is detected, the damping module imposes a reverse torque on the drill that dampens the torsional vibration. The reverse torque can be created by imparting a frictional resistance to the rotation of the drill string. The frictional resistance can be created externally, by extending friction pads from the damping module so that they contact the bore hole wall and drag along the bore hole as the drill string rotates, or internally by anchoring a housing mounted on the drill string to the wall of the bore hole and then imposing frictional resistance on a fluid, such as a magnetorheological fluid, flowing within the drill string.

Abstract: A system for damping vibration in a drill string can include a valve assembly having a supply of a fluid, a first member, and a second member capable of moving in relation to first member in response to vibration of the drill bit. The first and second members define a first and a second chamber for holding the fluid. Fluid can flow between the first and second chambers in response to the movement of the second member in relation to the first member. The valve assembly can also include a coil or a valve for varying a resistance of the fluid to flow between the first and second chambers.

Abstract: A method for preoperatively characterizing an individual patient's biomechanic function in preparation of implanting a prosthesis is provided. The method includes subjecting a patient to various activities, recording relative positions of anatomy during said various activities, measuring force environments responsive to said patient's anatomy and affected area during said various activities, characterizing the patient's biomechanic function from said relative positions and corresponding force environments, inputting the measured force environments, relative positions of knee anatomy, and patient's biomechanic function characterization into one or more computer simulation models, inputting a computer model of the prosthesis into said one or more computer simulation models, and manipulating the placement of the prosthesis in the computer simulation using said patient's biomechanic function characterization and said computer model of the prosthesis to approximate a preferred biomechanical fit of the prosthesis.

Abstract: A system for damping vibration in a drill string can include a magnetorheological fluid valve assembly having a supply of a magnetorheological fluid. A remanent magnetic field is induced in the valve during operation that can be used to provide the magnetic field for operating the valve so as to eliminate the need to energize the coils except temporarily when changing the amount of damping required The current to be supplied to the coil for inducing a desired magnetic field in the valve is determined based on the limiting hysteresis curve of the valve and the history of the magnetization of the value using a binary search methodology. The history of the magnetization of the valve is expressed as a series of sets of current and it resulting magnetization at which the current experienced a reversal compared to prior values of the current.

Abstract: The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither eosinophils nor mast cells are present in human CNV. The genetic or pharmacological targeting of CCR3 or eotaxins as disclosed herein inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation as it occurred in mice lacking eosinophils or mast cells and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing CNV than vascular endothelial growth factor-A (VEGF-A) neutralization, which is currently in clinical use, and, unlike VEGF-A blockade, not toxic to the mouse retina. In vivo imaging with CCR3-targeting quantum dots located spontaneous CNV invisible to standard fluorescein angiography in mice before retinal invasion.

Abstract: A system for damping vibration in a drill string can include a magnetorheological fluid valve assembly having a supply of a magnetorheological fluid, a first member, and a second member capable of moving in relation to first member in response to vibration of the drill bit. The first and second members define a first and a second chamber for holding the fluid. Fluid can flow between the first and second chambers in response to the movement of the second member in relation to the first member. The valve assembly can also include a coil for inducing a magnetic field that alters the resistance of the magnetorheological fluid to flow between the first and second chambers, thereby increasing the damping provided by the valve.

Abstract: A method for preoperatively characterizing an individual patient's biomechanic function in preparation of implanting a prosthesis is provided. The method includes subjecting a patient to various activities, recording relative positions of anatomy during the various activities, measuring force environments responsive to the patient's anatomy and affected area during the various activities, characterizing the patient's biomechanic function from the relative positions and corresponding force environments, inputting the measured force environments, relative positions of knee anatomy, and patient's biomechanic function characterization into the one or more computer simulation models, inputting a computer model of the prosthesis into the one or more computer simulation models, and manipulating the placement of the prosthesis in the computer simulation using the patient's biomechanic function characterization and the computer model of the prosthesis to approximate a preferred biomechanical fit of the prosthesis.

Abstract: A system for damping vibration in a drill string can include a valve assembly having a supply of a fluid, a first member, and a second member capable of moving in relation to first member in response to vibration of the drill bit. The first and second members define a first and a second chamber for holding the fluid. Fluid can flow between the first and second chambers in response to the movement of the second member in relation to the first member. The valve assembly can also include a coil or a valve for varying a resistance of the fluid to flow between the first and second chambers.

Abstract: A system for damping vibration in a drill string can include a valve assembly having a supply of a fluid, a first member, and a second member capable of moving in relation to first member in response to vibration of the drill bit. The first and second members define a first and a second chamber for holding the fluid. Fluid can flow between the first and second chambers in response to the movement of the second member in relation to the first member. The valve assembly can also include a coil or a valve for varying a resistance of the fluid to flow between the first and second chambers.

Abstract: A system and method for monitoring underground drilling in which vibration is monitored by creating a model of the drill string using finite element techniques or finite difference techniques and (i) predicting vibration by inputting real time values of operating parameters into the model, and then adjusting the model to agree with measured vibration data, (ii) predicting the weight on bit and drill string and mud motor speeds at which resonance will occur, as well as when stick-slip will occur, so that the operator can avoid operating regimes that will result in high vibration, (iii) determining vibration and torque levels along the length of the drill string based on the measured vibration and torque at one or more locations, (iv) determining the remaining life of critical components of the drill string based on the history of the vibration to which the components have been subjected, and (v) determining the optimum drilling parameters that will avoid excessive vibration of the drill string.

Abstract: A low profile patient specific cutting block for a knee comprises a plurality of bone interfacing portions and a cutting slot. The plurality of bone interfacing portions are configured to overlie portions of an end of a bone. The bone interfacing portions each have a surface generally a negative of the portion of the bone the bone interfacing portion overlies. The bone interfacing portions are angularly offset from each other such that a first of the bone interfacing portions overlies an anterior portion of the bone and a second of the bone interfacing portions overlies a portion of bone generally perpendicular to the anterior portion of hone. The cutting slot is oriented in a fixed position relative to the bone interfacing portions such that the cutting slot directs a cutting tool at a fixed angle and at a fixed depth from the bone interfacing portions.

Abstract: An apparatus for measuring the bending on a drill bit operating down hole in a well may comprise at least three pockets circumferentially spaced equidistantly around the drill collar of the drill string to which the drill bit is attached. Four strain gauges are equidistantly circumferentially spaced around each of the pockets so as to form first and second sets of strain gauges. The strain gauges in the first set are connected into one Wheatstone bridge while the gauges in the second set are connected in a second bridge. Each of the strain gauges that are oriented similarly within each of the pockets are connected in series within a single leg of a bridge so that the output voltage of the bridge is unaffected by bending in the drill string. The output of first bridge is used to determine the bending on the drill bit.

Abstract: A method positions a profile of a prosthetic component on the three-dimensional model of a limb. Patient-specific anatomical data of the limb is gathered. First and second anatomical landmarks are identified to determine a first spatial relationship. A third anatomical landmark is identified to determine a second spatial relationship with respect to the first spatial relationship. The profile of the prosthetic component is positioned in all but one degree of freedom. A fourth anatomical landmark is identified to position the profile of the prosthetic component in the one remaining degree of freedom.

Abstract: Methods and apparatus for performing knee arthroplasty, including, but not limited to, bicruciate retaining knee arthroplasty, are described herein. Methods and apparatus for preparing a distal femur for a femoral implant as well as methods and apparatus for preparing a proximal tibia for a tibial implant are described. These methods and apparatus, in at least some embodiments and uses, facilitate decreasing the complexity of knee arthroplasty procedures such as bicruciate retaining procedures, while maintaining, if not improving on, the safety, accuracy and/or effectiveness of such procedures.

Abstract: Methods and apparatus for performing knee arthroplasty, including, but not limited to, bicruciate retaining knee arthroplasty, are described herein. Methods and apparatus for preparing a distal femur for a femoral implant as well as methods and apparatus for preparing a proximal tibia for a tibial implant are described. These methods and apparatus, in at least some embodiments and uses, facilitate decreasing the complexity of knee arthroplasty procedures such as bicruciate retaining procedures, while maintaining, if not improving on, the safety, accuracy and/or effectiveness of such procedures.