Patents by Inventor Mark Entman

Mark Entman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cleaved serum response factor in cardiac diagnosis and therapy
    Patent number: 7582478
    Abstract: The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: September 1, 2009
    Assignee: Baylor College of Medicine
    Inventors: Robert J. Schwartz, Lei Wei, Jiang Chang, Mark Entman
  • Selective inhibition of rock1 in cardiac therapy
    Publication number: 20060142193
    Abstract: The present invention is directed to the treatment and/or prevention of disease as it relates to Rho kinase. In specific embodiments, disease is treated and/or prevented through the administration of an agent that selectively inhibits ROCK1. In specific embodiments, it inhibits ROCK1 and not ROCK2. In other specific embodiments, the disease is cardiac disease.
    Type: Application
    Filed: November 9, 2005
    Publication date: June 29, 2006
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: Lei Wei, Robert Schwartz, Jiang Chang, Mark Entman
  • Cleaved serum response factor in cardiac diagnosis and therapy
    Publication number: 20040214771
    Abstract: The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.
    Type: Application
    Filed: January 22, 2004
    Publication date: October 28, 2004
    Applicant: Baylor College of Medicine
    Inventors: Robert J. Schwartz, Lei Wei, Jiang Chang, Mark Entman
  • Heart derived cells for cardiac repair
    Publication number: 20040126879
    Abstract: The present invention is drawn to compositions and methods of using the same to cardiovascular disease. The compositions of the present invention are cardiac stem cells that are c-kitneg/CD31+/CD38+ and express telomerase reverse transcriptase.
    Type: Application
    Filed: August 29, 2003
    Publication date: July 1, 2004
    Applicant: Baylor College of Medicine
    Inventors: Michael D. Schneider, Hidemasa Oh, Mark Entman