Abstract: A method includes obtaining image data that includes contrast enhanced spectral image data from a contrast enhanced spectral volume scan of a subject. The method further includes obtaining images that include a set of localized dynamic contrast enhanced images from a localized dynamic contrast enhanced series scan of the subject. The method further includes determining a fluid volume map based on the image data and the images. A computing system includes a computer readable storage medium with computer readable instructions for a fluid volume map determiner. The instructions determine a volumetric fluid volume map based on contrast enhanced spectral volume image data from a contrast enhanced spectral volume scan and a set of localized dynamic contrast enhanced images from a localized dynamic contrast enhanced series scan. The computing system further includes a processor that implements the instructions and determines the volumetric fluid volume map.