Patents by Inventor Mark Esposito

Mark Esposito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210155602
    Abstract: Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform Ia3 (ALDHIa3) and arc useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.
    Type: Application
    Filed: January 29, 2021
    Publication date: May 27, 2021
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Mark ESPOSITO, Yibin KANG
  • Publication number: 20200175591
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Application
    Filed: September 13, 2019
    Publication date: June 4, 2020
    Applicant: Cboe Exchange, Inc.
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Patent number: 10417708
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 17, 2019
    Assignee: Cboe Exchange, Inc.
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Patent number: 10016203
    Abstract: A tourniquet for restricting a flow of blood in a body part is presented. In accordance with embodiments of the present invention, the tourniquet comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: July 10, 2018
    Assignee: Composite Resources, Inc.
    Inventor: Mark Esposito
  • Publication number: 20160302799
    Abstract: A tourniquet for restricting a flow of blood in a body part is presented. In accordance with embodiments of the present invention, the tourniquet comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Application
    Filed: October 28, 2014
    Publication date: October 20, 2016
    Inventor: Mark Esposito
  • Patent number: 8888807
    Abstract: A tourniquet for restricting a flow of blood in a body part is presented. In accordance with embodiments of the present invention, the tourniquet comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: November 18, 2014
    Assignee: Phil Durango LLC
    Inventor: Mark Esposito
  • Publication number: 20140277103
    Abstract: A quick-connect buckle is provided for a tourniquet, the quick-connect buckle including a dovetail tongue and groove coupling system with an initial coupling position and a final coupling position corresponding to a tensioned configuration. The quick-connect coupler also has application beyond use in tourniquets. Accordingly, the quick-connect coupler can be combined with a strap to form an all-purpose binding device used for a variety of purposes. Methods associated with the quick-connect buckle are also described.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: PHIL DURANGO LLC
    Inventor: Mark ESPOSITO
  • Publication number: 20130267994
    Abstract: An occlusion attachment device for coupling with a tourniquet includes a projection that can be attached using a platform to a portion of a tourniquet in an emergency situation, thereby providing a modified tourniquet that includes the projection. Clip-on, slide-on, and clamping structures associated with the platform are described.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 10, 2013
    Applicant: PHIL DURANGO LLC
    Inventors: Tyler L. CROWDER, Dan CEDRONE, Sarah A. CROWDER, Mark ESPOSITO
  • Publication number: 20130238481
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Application
    Filed: December 14, 2012
    Publication date: September 12, 2013
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Patent number: 8346652
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: January 1, 2013
    Assignee: Chicago Board Options Exchange, Incorporated
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Publication number: 20120158567
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, and providing market making rights of varying degrees to entities having a physical presence on the floor of the exchange and entities remotely located away from the trading floor. The system includes a trade engine configured for receiving orders from market makers on and away from the trading floor. The system also includes executable instructions for allocating to designated primary market makers a portion of an incoming order remaining after first trading against public customer orders.
    Type: Application
    Filed: August 23, 2011
    Publication date: June 21, 2012
    Inventors: Anthony J. Carone, Mark A. Esposito, Stuart J. Kipnes, Anthony Montesano, Eileen C. Smith, Edward T. Tilly
  • Patent number: 8047850
    Abstract: A training tourniquet for use in training a user or another person, such as a medic, includes a non-functioning tensioning mechanism to model application of developing a tensile force in a strap of a tourniquet. The training tourniquet has particular application to training field personnel, such as medics and soldiers as to how to apply a tourniquet, without actually creating a compressive force that could damage a person's tissue during the training or practice sessions. In one embodiment, an inoperative windlass can be rotated to simulate the action necessary to create tension in a strap of a real tourniquet, however, the inoperative windlass spins around without actually tightening a strap of the training tourniquet.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: November 1, 2011
    Assignee: Phil Durango, LLC
    Inventors: Mark Esposito, Jonathan Bennett
  • Publication number: 20110091143
    Abstract: A seal component (100, 200) having a triple-lip configuration for sealing against a moving surface, such as the inner ring race surface (12, 12?) of a spherical plain bearing (14, 14?). The triple-lip configuration incorporates a pair of outward inclined seal lips (102, 202, 104, 204) for providing protection from external contaminates, and a third inwardly inclined seal lip (106, 206) which is orientated to provide lubricant or grease retention within the sealed bearing (14, 14?). The size and configuration of the third seal lip (106, 206) is selected to minimize surface friction and to avoid seal lip inversion during oscillatory motion of the bearing components during use. A retention surface (110a, 210) is disposed to abut against the outer ring race surface (10b, 10b) to resist roll-out displacement of the seal component (100, 200) during use.
    Type: Application
    Filed: May 28, 2009
    Publication date: April 21, 2011
    Applicant: THE TIMKEN COMPANY
    Inventors: Timothy P. Murphy, Liviu V. Anton, Ioana C. Savin, Richard Borowski, Mark Esposito
  • Publication number: 20110087264
    Abstract: A tourniquet for restricting a flow of blood in a body part is presented. In accordance with embodiments of the present invention, the tourniquet comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Application
    Filed: November 24, 2010
    Publication date: April 14, 2011
    Applicant: PHIL DURANGO LLC
    Inventor: Mark ESPOSITO
  • Patent number: 7892253
    Abstract: A tourniquet for restricting a flow of blood in a body part comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. At least one embodiment of the present invention comprises a buckle having one or more of a raised intermediate bar and one or more teeth for contacting a portion of the first elongated member. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Grant
    Filed: August 28, 2007
    Date of Patent: February 22, 2011
    Assignee: Phil Durango, LLC
    Inventors: Mark Esposito, Jonathan Bennett
  • Patent number: 7842067
    Abstract: A tourniquet for restricting a flow of blood in a body part is presented. In accordance with embodiments of the present invention, the tourniquet comprises a first elongated member, and a second elongated member in slidable engagement with the first elongated member. In addition, the tourniquet includes a tensioning mechanism connected to the second elongated member, wherein a compressive force is applied to the body part upon applying a tensile force to the second elongated member using the tensioning mechanism. The tourniquet is suited for emergency use, and may be applied by using only one hand. Thus, the tourniquet may be applied, manipulated and tightened by the wearer, even if the wearer is limited to the use of a single hand.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: November 30, 2010
    Inventor: Mark Esposito
  • Publication number: 20100082473
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Application
    Filed: September 16, 2009
    Publication date: April 1, 2010
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Publication number: 20090292634
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, and providing market making rights of varying degrees to entities having a physical presence on the floor of the exchange and entities remotely located away from the trading floor. The system includes a trade engine configured for receiving orders from market makers on and away from the trading floor. The system also includes executable instructions for allocating to designated primary market makers a portion of an incoming order remaining after first trading against public customer orders.
    Type: Application
    Filed: April 30, 2009
    Publication date: November 26, 2009
    Inventors: Anthony J. Carone, Mark A. Esposito, Stuart J. Kipnes, Anthony Montesano, Eileen C. Smith, Edward T. Tilly
  • Patent number: 7613650
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, but limiting market making to only those entities having a physical presence on the floor of the exchange. Methods of enhancing the hybrid electronic and open-outcry exchange also include automatically eliminating crossed quotes and locked quotes while permitting certain orders to trade against locked quotes.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: November 3, 2009
    Assignee: Chicago Board Options Exchange, Incorporated
    Inventors: Eileen C. Smith, Anthony Montesano, Edward T. Tilly, Mark A. Esposito, Stuart J. Kipnes, Anthony J. Carone
  • Patent number: 7552083
    Abstract: A system and method of allocating orders in an exchange configured for trading by a combination of electronic and open-outcry trading mechanisms is provided. One method includes permitting multiple quotes to be disseminated to the market, and providing market making rights of varying degrees to entities having a physical presence on the floor of the exchange and entities remotely located away from the trading floor. The system includes a trade engine configured for receiving orders from market makers on and away from the trading floor. The system also includes executable instructions for allocating to designated primary market makers a portion of an incoming order remaining after first trading against public customer orders.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: June 23, 2009
    Assignee: Chicago Board Options Exchange, Incorporated
    Inventors: Anthony J. Carone, Mark A. Esposito, Stuart J. Kipnes, Anthony Montesano, Eileen C. Smith, Edward T. Tilly