Patents by Inventor Mark Exley

Mark Exley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11389771
    Abstract: Asymmetric composite membranes and methods for their preparation are disclosed. The membranes comprise a cross-linked poly(vinyl alcohol) polymer coated on a film of cross-linked sulfonated poly(ether ether ketone) adhered to a sheet of hydrophilicitized microporous polyolefin. The microporous polyolefin is typically microporous poly(ethylene). The membranes have improved selectivity with the regard to the rejection of solutes in reverse osmosis and ultrafiltration applications.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: July 19, 2022
    Assignee: HYDROXSYS HOLDINGS LIMITED
    Inventors: Lenka Benacek Craft, Mark Exley, Ashveen Vikash Nand, Dylan Townshend Gifford
  • Publication number: 20220193620
    Abstract: Durable asymmetric composite membranes comprising of a film of cross-linked poly(ether ether ketone) adhered to a sheet of hydrophilicitized microporous polyolefin are disclosed. The membranes are suitable for use in the recovery or removal of water from feed streams where repeated clean-in-place protocols are required such as in the processing of dairy products. The membranes are also suitable for use in the preparation of durable asymmetric composite membranes with improved rejection characteristics.
    Type: Application
    Filed: March 8, 2022
    Publication date: June 23, 2022
    Inventors: Lenka Benacek CRAFT, Mark EXLEY, Ashveen Vikash NAND
  • Patent number: 11291215
    Abstract: Durable asymmetric composite membranes consisting essentially of a film of cross-linked sulfonated poly(ether ether ketone) adhered to a sheet of hydrophilicitized microporous poly(ethylene) are disclosed. The membranes have application in the recovery of water from feed streams where the ability to clean in situ is desirable, for example in dairy processing. Methods of preparing cross-linked sulfonated poly(ether ether ketone) suitable for use as the rejection layer and hydrophilicitized sheets of microporous poly(ethylene) suitable for use as the support layer of such membranes are also disclosed.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: April 5, 2022
    Assignee: HYDROXSYS HOLDINGS LIMITED
    Inventors: Daryl Joseph Briggs, Lenka Benacek Craft, Ashveen Vikash Nand, Mark Exley
  • Publication number: 20200346170
    Abstract: Asymmetric composite membranes and methods for their preparation are disclosed. The membranes comprise a cross-linked poly(vinyl alcohol) polymer coated on a film of cross-linked sulfonated poly(ether ether ketone) adhered to a sheet of hydrophilicitized microporous polyolefin. The microporous polyolefin is typically microporous poly(ethylene). The membranes have improved selectivity with the regard to the rejection of solutes in reverse osmosis and ultrafiltration applications.
    Type: Application
    Filed: October 3, 2016
    Publication date: November 5, 2020
    Inventors: Lenka Benacek CRAFT, Mark EXLEY, Ashveen Vikash NAND
  • Publication number: 20190200631
    Abstract: Durable asymmetric composite membranes consisting essentially of a film of cross-linked sulfonated poly(ether ether ketone) adhered to a sheet of hydrophilicitized microporous poly(ethylene) are disclosed. The membranes have application in the recovery of water from feed streams where the ability to clean in situ is desirable, for example in dairy processing. Methods of preparing cross-linked sulfonated poly(ether ether ketone) suitable for use as the rejection layer and hydrophilicitized sheets of microporous poly(ethylene) suitable for use as the support layer of such membranes are also disclosed.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 4, 2019
    Inventors: Daryl Joseph BRIGGS, Lenka Benacek CRAFT, Ashveen Vikash NAND, Mark EXLEY
  • Patent number: 10335742
    Abstract: Durable asymmetric composite membranes consisting of a film of cross-linked poly(ether ether ketone) adhered to a sheet of hydrophilic microporous poly(ethylene) are disclosed. The membranes are suitable for use in the recovery or removal of water from feed streams where repeated clean-in-place protocols are required such as in the processing of dairy products.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: July 2, 2019
    Assignee: HYDROXSYS HOLDINGS LIMITED
    Inventor: Mark Exley
  • Publication number: 20180015424
    Abstract: Durable asymmetric composite membranes consisting of a film of cross-linked poly(ether ether ketone) adhered to a sheet of hydrophilic microporous poly(ethylene) are disclosed. The membranes are suitable for use in the recovery or removal of water from feed streams where repeated clean-in-place protocols are required such as in the processing of dairy products.
    Type: Application
    Filed: December 28, 2015
    Publication date: January 18, 2018
    Inventor: Mark Exley
  • Publication number: 20070160600
    Abstract: The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and J?Q+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
    Type: Application
    Filed: October 2, 2006
    Publication date: July 12, 2007
    Applicants: Beth Israel Deaconess Medical Center, Dana-Farber Cancer Institute
    Inventors: Mark Exley, Samuel Wilson, Steven Balk
  • Publication number: 20060286096
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Malcolm Gefter, Stephen Powers
  • Publication number: 20060286097
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philiip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060286094
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcoml Gefter
  • Publication number: 20060286098
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060286095
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060286099
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 21, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060280735
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 14, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060280736
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 14, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060239997
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: October 26, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060058220
    Abstract: Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are, disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
    Type: Application
    Filed: February 23, 2005
    Publication date: March 16, 2006
    Inventors: Philip Swain, Victoria Schad, Julia Greenstein, Mark Exley, Barbara Fox, Stephen Powers, Malcolm Gefter
  • Publication number: 20060002927
    Abstract: The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.
    Type: Application
    Filed: May 1, 2003
    Publication date: January 5, 2006
    Inventors: Mark Exley, Steven Balk, Simon Yue
  • Publication number: 20050152927
    Abstract: The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II.
    Type: Application
    Filed: August 30, 2004
    Publication date: July 14, 2005
    Applicant: IMMULOGIC PHARMACEUTICAL CORP.
    Inventors: Irwin Griffith, Joanne Pollock, Julian Bond, Richard Garman, Mei-Chang Kuo, Stephen Powers, Mark Exley, Xian Chen, Ze'ev Shaked