Patents by Inventor Mark F. Sistare

Mark F. Sistare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microelectronic device for electrochemical detection of nucleic acid hybridization
    Patent number: 7049068
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: May 23, 2006
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Electrochemical detection of nucleic acid hybridization
    Publication number: 20020106683
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Application
    Filed: November 6, 2001
    Publication date: August 8, 2002
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Electrochemical detection of nucleic acid hybridization
    Patent number: 6361951
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: March 26, 2002
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Microelectronic device
    Patent number: 6132971
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: October 17, 2000
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Electrochemical detection of nucleic acid hybridization
    Patent number: 5871918
    Abstract: A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable of oxidizing the preselected base in an oxidation-reduction reaction; (b) detecting the oxidation-reduction reaction; and (c) determining the presence or absence of the nucleic acid from the detected oxidation-reduction reaction at the preselected base. The method may be used in a variety of applications, including DNA sequencing, diagnostic assays, and quantitative analysis.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: February 16, 1999
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: H. Holden Thorp, Dean H. Johnston, Mary E. Napier, Carson R. Loomis, Mark F. Sistare, Jinheung Kim
  • Use of an alkaline prebath to activate an acidic peroxide bleach solution for processing color photographic elements
    Patent number: 5554491
    Abstract: Color photographic elements can be effectively and rapidly bleached using acidic peroxide bleaching solutions when an alkaline prebath solution is used to activate the acidic bleaching solution.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: September 10, 1996
    Assignee: Eastman Kodak Company
    Inventors: Terrence R. O'Toole, Mark F. Sistare
  • Processing of photographic elements using copper ligand complexes to catalyze peracid bleaching agents
    Patent number: 5508151
    Abstract: Copper (II) ligand complexes are useful to catalyze the activity of peracid bleaching agents. The complexes can be included in the bleaching solutions, or used in a suitable solution prior to the bleaching step. The ligands are .alpha.-diimines having sites available to complex with copper (II).
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: April 16, 1996
    Assignee: Eastman Kodak Company
    Inventors: Terrence R. O'Toole, Mark F. Sistare, Eric R. Schmittou